Abstract：
:Inflammation has been implicated as an etiological factor in different human cancers. Allelic variations in the genes implicated in inflammation are candidates as genetic determinants or markers of renal carcinoma risk. The present stud investigates whether polymorphisms of the genes that give rise to increases in the levels of proinflammatory cytokines and chemokines are associated with an increased risk of renal carcinoma. To this effect, a number of case-control studies were designed to assess the correlation between renal carcinoma and polymorphisms IL10-1082 A/G (rs 1800896), IL10-592 A/C (rs 1800872), IL10-819 C/T (rs 1800871), IL10-1082 A/G, IL4-590 C/T (rs 2243250), TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587), MCP-1 2518 G/A (rs 1024611), CTLA-4/+49 A/G (rs 231775) and CTLA-4 CT60 A/G (rs 3087243) in 127 renal carcinoma patients and in 176 healthy subjects. The results obtained in relation to cytokine polymorphism IL-10-1082 A/G indicate that AG heterozygosity status is the principal risk factor in relation to locally advanced or metastatic tumor stage and renal carcinoma. In the case of the molecule CTLA4, the results obtained in renal cancer reveal an association between the polymorphisms of the CTLA-4 gene and an increased risk of developing renal cell carcinoma. A high genotypic frequency of polymorphisms CTLA4/CT60-AA and CTLA4/A49G-AA is observed in patients with renal cell carcinoma versus the controls. An association has been established between polymorphism CTLA4/CT60 and tumor grade in patients with renal cell carcinoma. Logistic regression analysis has confirmed these data, demonstrating a high frequency of the AA genotype in patients with high-grade tumors. The results obtained support the hypothesis that different genetic factors implicated in the regulation of adaptive immune responses, stromal cell composition and local cytokine production levels may be crucial elements in the modification of the clinicopathological parameters of renal carcinoma.
journal_name
Actas Urol Espjournal_title
Actas urologicas espanolasauthors
Sáenz López P,Vázquez Alonso F,Romero JM,Carretero R,Tallada Buñuel M,Ruiz Cabello F,Cózar Olmo JMdoi
10.1016/s0210-4806(09)74180-4subject
Has Abstractpub_date
2009-05-01 00:00:00pages
474-81issue
5eissn
0210-4806issn
1699-7980pii
S0210-4806(09)74180-4journal_volume
33pub_type
杂志文章abstract：:Patient suffering from vesical carcinoma, which is identified as small cells (oat cells) carcinoma. We carried out a histochemical study with H.C.G. and C.E.A. and analyse the results obtained. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：OBJECTIVE:To value if the increase in the number of cylinders in the prostate's biopsy raise the diagnostic performance of this test. MATERIAL AND METHOD:In March 2005 we initiate this prospective study with patients who are subject to a first prostate Biopsy by a PSA between 4 and 10 ng/ml and negative rectal touch. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(07)73587-8
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:To present to report the first case of ureteral lithiasis resolved using a new endoscopic approach, which we call microureteroscopy (m-URS) and attempts to reduce the ureteral damage caused by conventional instrumentation. MATERIAL AND METHODS:We selected a 53-year-old patient with a 16-mm calculus in the r...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2014.08.004
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:Traditionally, urine cytology has been considered as the gold standard for bladder cancer screening. However, new methods are playing new roles in these cases. In order to assess the value of cytology of voided urine we performed one comparative study between cytology and biopsy. METHODS:We retrospectively ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(08)73958-5
更新日期：2008-10-01 00:00:00
abstract：:An asymptomatic case of cystic renal carcinoma is presented. The only diagnosis of certainty was given by a marked increase in L.D.H. levels in the fluid of the tumor after puncture. The pros and cons of imaging studies, and the relative lack of value of aspiration cytology when negative results are encountered are di...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Basic semen tests nowadays contain no variables that may allow to certify that a man is fertile. Starting from this premise it could be clinically very useful, for the diagnosis of male infertility, to evaluate a parameter that may be related to sexual maturity and be specific of the germinal tissue, such as the C4-la...
journal_title：Actas urologicas espanolas
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：INTRODUCTION:Urinary incontinence (UI) is a complication of radical prostatectomy (RP) and transurethral resection of the prostate (TURP). The gold-standard treatment is the artificial urinary sphincter, however, new treatments have been investigated. OBJECTIVE:To examine the outcome of an adjustable transobturator ma...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2017.07.011
更新日期：2018-05-01 00:00:00
abstract：:Sarcomatoid bladder carcinoma is a high-grade neoplasm and accounts for approximately 0,3% of all bladder malignancies. Sarcomatoid carcinoma originates from transitional cells of the bladder. Sarcomatoid carcinoma is charactericed by a epithelial component and a sarcomatoid component, consisting of spindle cells, tha...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(09)74175-0
更新日期：2009-04-01 00:00:00
abstract：:The use of serum prostate-specific antigen screening to facilitate early detection of prostate cancer has resulted in a dramatic increase in the number of prostate needle core biopsies which pathologists must examine. This has been accompanied by a strong increase in the number of biopsies with ambiguous lesions, and ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/s0210-4806(07)73764-6
更新日期：2007-10-01 00:00:00
abstract：:The fate of some infiltrant tumours of the bladder locally advanced (pT2-3NxM0) which were radically resected, with or without association to other treatments, has been similar to those in which initial radical treated was used. To carry out simultaneously a radical RTU as a local action plus systemic chemotherapy (M-...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：
更新日期：1992-03-01 00:00:00
abstract：:We report a case of a carcinoid tumor originated in testicle associated with mature teratoma in a 31 years old male. Primary gonadal location of this tumor is unusual, moreover when associated with teratoma. Early diagnosis and treatment determine the prognostic of the patients affected of this neoplasm since the only...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(08)73863-4
更新日期：2008-04-01 00:00:00
abstract：:We studied two groups of patients in order to evaluate the frequency of association between renal dysplasia and vesicoureteral reflux. The first was composed of 19 patients with dysplastic kidneys, 15 of whom were studied by means of micturition cystourethrography. The second group was made up of 86 patients with 124 ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:Despite the growing interest on Urinary Incontinence (UI) in our country, nocturnal enuresis and Overactive Bladder (OAB), there are no epidemiologic studies on the prevalence of these health problems in the different affected groups of the general population. PATIENTS AND METHODS:This is an epidemiologic, ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,多中心研究
doi：10.1016/s0210-4806(09)74117-8
更新日期：2009-02-01 00:00:00
abstract：:We report the case of a 26 years old female who presented, as a casual finding, a right complete ureteral triplicity (probably Campbell's tipe I) with no other associated abnormalities. Despite ureteral duplication is a frequent urological anomaly, the presence of three ureters occurring in the same side, in a complet...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/s0210-4806(04)73179-4
更新日期：2004-11-01 00:00:00
abstract：:The incidence of multiple tumours in renal cancer ranges between 1 and 30%. In these cases, it becomes very difficult to differentiate between adenoma and carcinoma just by using conventional methods, particularly in borderline cases. We carried out primary cultures and subsequent cytogenetic studies in 2 patients wit...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：CONTEXT:The European Association of Urology (EAU) Guidelines Office has set up a guideline working panel to analyse the scientific evidence published in the world literature on lasers in urologic practice. OBJECTIVE:Review the physical background and physiologic and technical aspects of the use of lasers in urology, a...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,实务指引,评审
doi：10.1016/j.acuro.2012.05.005
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:To analyse the success of transvaginal urethrolysis in resolving voiding dysfunction in patients following an anti-incontinence procedure. MATERIALS AND METHODS:A retrospective chart review was performed on 20 patients who had undergone transvaginal urethrolysis for urethral obstruction following an anti-incon...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(05)73224-1
更新日期：2005-02-01 00:00:00
abstract：:Schwannoma or neurilemmoma designate a tumour that originates in the Schwann cells of peripheral nerves, therefore occurring anywhere in the body. They are very rare in the penis. In the literature are reported twenty seven cases of penile schwannoma. We report a case of multiple schwannoma of the penis and make a bri...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/s0210-4806(06)73540-9
更新日期：2006-09-01 00:00:00
abstract：:Review of 158 cases of renal traumatism attended ar the Urology Service of "La Fe" Hospital from 1984 to 1995. We analyze the indications of radiological study of the polytraumatized patient, the different classifications of renal traumatism and the changes produced in the diagnosis protocol, after substituting urogra...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
abstract：OBJECTIVE:It is aimed to characterize the true relationship of the cold ischemia time (CIT) with graft survival and with the principal post-transplantation events. MATERIAL AND METHODS:We analyzed 378 kidney transplants, studying the relationship of the CIT with graft survival using a univariate analysis according to ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2011.03.005
更新日期：2011-09-01 00:00:00
abstract：:During the first ten years (1981-1990) of our organ transplantation program a total of 395 Renal Transplants (RTx) have been carried out in our Unit, 90 of which in 88 patients had to be subsequently transplantectomized. In 32 of them the reason was acute rejection (35%) including 7 renal rhexis, and in 30 chronic rej...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：INTRODUCTION:Bladder cancer is a disease with a high prevalence due to its recurrence rate. Transurethral resection of the bladder (TURB) is the treatment in initial stages. Nevertheless, a high percentage of non-muscle-invasive tumors treated will have a recurrence 1-2 years afterwards. Adjuvant quemotherapy or immuno...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,随机对照试验
doi：10.1016/s0210-4806(08)73940-8
更新日期：2008-09-01 00:00:00
abstract：:Anatomical and physiological changes in the urinary tract develop during pregnancy. These changes may affect the urinary outflow. Urinary symptoms may develop during pregnancy in previously asymptomatic patients. Most of these symptoms will vanish after delivery. Some of them remain and others will become worse in con...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(99)72367-3
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Taking into account the high prevalence in our country of Overactive Bladder Syndrome (OAB) ("urgency", with or without incontinence, sometimes associated to an increase in frequency and/or nocturia) and the difficulty to identify it, it would be interesting to have a short patient self assessment screening ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(06)73578-1
更新日期：2006-11-01 00:00:00
abstract：:Micropapillary carcinoma is an uncommon pathologic variant of bladder carcinoma with aggressive behavior. Its usual presentation is like a high grade and high stage carcinoma and associated with other histologic types in different proportion. It doesn't differ clinically from normal transitional cell carcinoma of the ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/s0210-4806(05)73263-0
更新日期：2005-04-01 00:00:00
abstract：INTRODUCTION:With the routine use of prostate specific antigen, focal carcinomas and atypical small acini proliferation (ASAP) are currently detected more frequently. The number of sections per cylinder needed to detect most of them is still unknown. METHODS:We reviewed 250 sextant prostate biopsies in the 2008-2011 p...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2012.04.002
更新日期：2012-11-01 00:00:00
abstract：INTRODUCTION:Urolithiasis is a disease having a high recurrence rate and associated morbidity. A not well quantified increase is being seen in recent years that could be related with various factors. The main purpose of our study has been to estimate urolithiasis prevalence and incidence in the region of Andalusia, det...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2014.02.006
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:To explore the management of lower urinary tract symptoms (LUTS) in men in Spain and assess the compliance with recommendations established in the European Association of Urology (EAU) guidelines. MATERIAL AND METHODS:MERCURY was an epidemiological and cross-sectional study which involved 227 Urology Units ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2017.12.003
更新日期：2018-06-01 00:00:00
abstract：:The stimulation of renal innervation activates vasoconstrictor mechanisms that compromise the parenchyma. In order to know the intensity and duration of these effects continuous electric stimulation was applied to the greater splanchnic nerve in 14 dogs for half an hour, completing both a pre and post monitoring of eq...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Presentation of one case of ammonium-magnesium phosphate calculi breakdown using systemic medical treatment with oral Acetohydroxamine acid dosed at 125 mg/8 h and antibiotic therapy based on the antibiogram results. This type of treatment is generally used in an attempt to eradicate the infection, and as prophylaxis ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
