Orbito-frontal cortex is necessary for temporal context memory.

Abstract:

:Lesion and neuroimaging studies suggest that orbito-frontal cortex (OFC) supports temporal aspects of episodic memory. However, it is unclear whether OFC contributes to the encoding and/or retrieval of temporal context and whether it is selective for temporal relative to nontemporal (spatial) context memory. We addressed this issue with two complimentary studies: functional magnetic resonance imaging to measure OFC activity associated with successful temporal and spatial context memory during encoding and retrieval in healthy young participants, and a neuropsychological investigation to measure changes in spatial and temporal context memory in OFC lesion patients. Imaging results revealed that OFC contributed to encoding and retrieval of associations between objects and their temporal but not their spatial contexts. Consistent with this, OFC patients exhibited impairments in temporal but not spatial source memory accuracy. These results suggest that OFC plays a critical role in the formation and subsequent retrieval of temporal context.

journal_name

J Cogn Neurosci

authors

Duarte A,Henson RN,Knight RT,Emery T,Graham KS

doi

10.1162/jocn.2009.21316

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

1819-31

issue

8

eissn

0898-929X

issn

1530-8898

journal_volume

22

pub_type

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