Abstract：
:Free recall is a fundamental paradigm for studying memory retrieval in the context of minimal cue support. Accordingly, free recall has been extensively studied using behavioral methods. However, the neural mechanisms that support free recall have not been fully investigated due to technical challenges associated with probing individual recall events with neuroimaging methods. Of particular concern is the extent to which the uncontrolled latencies associated with recall events can confer sufficient design efficiency to permit neural activation for individual conditions to be distinguished. The present study sought to rigorously assess the feasibility of testing individual free recall events with fMRI. We used both theoretically and empirically derived free recall latency distributions to generate simulated fMRI data sets and assessed design efficiency across a range of parameters that describe free recall performance and fMRI designs. In addition, two fMRI experiments empirically assessed whether differential neural activation in visual cortex at onsets determined by true free recall performance across different conditions can be resolved. Collectively, these results specify the design and performance parameters that can provide comparable efficiency between free recall designs and more traditional jittered event-related designs. These findings suggest that assessing BOLD response during free recall using fMRI is feasible, under certain conditions, and can serve as a powerful tool in understanding the neural bases of memory search and overt retrieval.
journal_name
J Cogn Neuroscijournal_title
Journal of cognitive neuroscienceauthors
Oztekin I,Long NM,Badre Ddoi
10.1162/jocn.2009.21350subject
Has Abstractpub_date
2010-10-01 00:00:00pages
2238-50issue
10eissn
0898-929Xissn
1530-8898journal_volume
22pub_type
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
pub_type： 临床试验,杂志文章
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journal_title：Journal of cognitive neuroscience
pub_type： 杂志文章
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更新日期：2002-11-15 00:00:00
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
pub_type： 杂志文章
doi：10.1162/jocn.1995.7.1.1
更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：1997-03-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Journal of cognitive neuroscience
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