Abstract:
:Invasive procedures, such as the lumbar puncture, can cause anxiety and pain in children undergoing treatment for acute lymphoblastic leukaemia (ALL). We investigated the safety and efficacy of two different protocols for analgo-sedation in 20 children with ALL undergoing lumbar puncture. We have conducted a prospective, cross-over study. Protocol A was composed of an association between propofol and alfentanil. Protocol B consisted in the combination of propofol and ketamine. We also evaluated the levels of nerve growth factor, substance P and enkephalins in the cerebrospinal fluid of these patients. All patients showed a satisfactory sedation and analgesia. We found a statistically significant difference of vital parameters between protocol A and protocol B, while there were no significant differences between sedation scores and the other parameters evaluated. Patients in protocol A showed a higher incidence of major side effects, such as respiratory depression. Pain neuromediator levels did not show any statistical difference between the two groups. This study shows that both protocols are effective to obtain a good sedation and analgesia in children with ALL undergoing lumbar puncture, but the association between propofol and ketamine appears to be safer due to the lower incidence of side effects.
journal_name
Eur J Cancer Care (Engl)journal_title
European journal of cancer careauthors
Chiaretti A,Ruggiero A,Barone G,Antonelli A,Lazzareschi I,Genovese O,Paiano S,Sammartino M,Maurizi P,Riccardi Rdoi
10.1111/j.1365-2354.2008.01006.xsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
212-20issue
2eissn
0961-5423issn
1365-2354pii
ECC1006journal_volume
19pub_type
杂志文章abstract::The purpose of this study was to examine the effect of a whole body exercise programme and dragon boat training on changes in arm volume in breast cancer survivors. A total of 16 female breast cancer survivors with no clinical history of lymphoedema volunteered. The 20-week exercise programme consisted of resistance a...
journal_title:European journal of cancer care
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