A selection model for longitudinal binary responses subject to non-ignorable attrition.

abstract：:For patients who were previously treated for prostate cancer, salvage hormone therapy is frequently given when the longitudinal marker prostate-specific antigen begins to rise during follow-up. Because the treatment is given by indication, estimating the effect of the hormone therapy is challenging. In a previous pape...

journal_title：Statistics in medicine

authors： Taylor JM,Shen J,Kennedy EH,Wang L,Schaubel DE

更新日期：2014-01-30 00:00:00

abstract：:Quantifying socioeconomic disparities and understanding the roots of inequalities are growing topics in cancer research. However, socioeconomic differences are challenging to investigate mainly due to the lack of accurate data at individual-level, while aggregate indicators are only partially informative. We implement...

journal_title：Statistics in medicine

authors： Mezzetti M,Palli D,Dominici F

更新日期：2020-01-15 00:00:00

abstract：:We analyse the effect of using prevalence rates based on populations with different sizes in the power of spatial independence tests. We compare the well known spatial correlation Moran's index to three indexes obtained after adjusting for population density, one proposed by Oden, another proposed by Waldhör, and a th...

journal_title：Statistics in medicine

authors： Assunção RM,Reis EA

更新日期：1999-08-30 00:00:00

abstract：:Korn and Whittemore have presented methods for analyzing longitudinal data where the number of observations per individual is large relative to the number of variables considered for each subject. However, this is often not the case in epidemiologic studies, since one usually collects data at relatively few time point...

journal_title：Statistics in medicine

authors： Rosner B,Muñoz A,Tager I,Speizer F,Weiss S

更新日期：1985-10-01 00:00:00

abstract：:Relative potency is a measure that has been used for many years to summarize the comparison of dose-response curves in parallel line bioassays. When response curves for two preparations are not parallel the traditional definition of relative potency no longer applies. We review the concept of relative potency and show...

journal_title：Statistics in medicine

authors： Kaiser MS,Siev D

更新日期：1997-05-30 00:00:00

abstract：:The back-calculation method has been used to estimate the number of HIV infections from AIDS incidence data in a particular population. We present an extension of back calculation that provides estimates of the numbers of HIV infectives in different stages of infection. We model the staging process with a time-depende...

journal_title：Statistics in medicine

authors： Longini IM Jr,Byers RH,Hessol NA,Tan WY

更新日期：1992-04-01 00:00:00

abstract：:Health questionnaires are often built up from sets of questions that are totaled to obtain a sum score. An important consideration in designing questionnaires is to minimize respondent burden. An increasingly popular method for efficient measurement is computerized adaptive testing; unfortunately, many health question...

journal_title：Statistics in medicine

authors： Smits N,Finkelman MD

更新日期：2014-02-10 00:00:00

abstract：:The randomized clinical trial, LU19, conducted by the Medical Research Council Lung Cancer Working Party, was designed to compare ACE (doxorubicin, cyclophosphamide and etoposide) chemotherapy plus G-CSF (granulocyte colony-stimulating factor) at 2-week intervals versus ACE chemotherapy alone at standard 3-week interv...

journal_title：Statistics in medicine

authors： Qian W,Parmar MK,Sambrook RJ,Fayers PM,Girling DJ,Stephens RJ

更新日期：2000-10-15 00:00:00

abstract：:Recurrent event data occur in many clinical and observational studies, and in these situations, there may exist a terminal event such as death that is related to the recurrent event of interest. In addition, sometimes more than one type of recurrent events may occur, that is, one may encounter multivariate recurrent e...

journal_title：Statistics in medicine

authors： Zhu L,Sun J,Srivastava DK,Tong X,Leisenring W,Zhang H,Robison LL

更新日期：2011-11-10 00:00:00

abstract：:We propose a joint modeling approach to investigating the observed and latent risk factors of mixed types of outcomes. The proposed model comprises three parts. The first part is an exploratory factor analysis model that summarizes latent factors through multiple observed variables. The second part is a proportional h...

journal_title：Statistics in medicine

authors： Pan D,Wei Y,Song X

更新日期：2020-12-09 00:00:00

abstract：:In time-to-event analysis, the traditional summary measures have been based on the hazard function, survival function, quantile event time, restricted mean event time, and residual lifetime. Under competing risks, furthermore, typical summary measures have been the cause-specific hazard function and cumulative inciden...

journal_title：Statistics in medicine

authors： Jia Y,Jeong JH

更新日期：2021-01-06 00:00:00

abstract：:The Wilcoxon-Mann-Whitney (WMW) test is often used to compare the means or medians of two independent, possibly nonnormal distributions. For this problem, the true significance level of the large sample approximate version of the WMW test is known to be sensitive to differences in the shapes of the distributions. Base...

journal_title：Statistics in medicine

authors： Fagerland MW,Sandvik L

更新日期：2009-05-01 00:00:00

abstract：:We consider using observational data to estimate the effect of a treatment on disease recurrence, when the decision to initiate treatment is based on longitudinal factors associated with the risk of recurrence. The effect of salvage androgen deprivation therapy (SADT) on the risk of recurrence of prostate cancer is in...

journal_title：Statistics in medicine

authors： Kennedy EH,Taylor JM,Schaubel DE,Williams S

更新日期：2010-11-10 00:00:00

abstract：:The use of classification and regression tree (CART) methodology is explored for the diagnosis of patients complaining of anterior chest pain. The results are compared with those previously obtained using correspondence analysis and independent Bayes classification. The technique is shown to be of potential value for ...

journal_title：Statistics in medicine

authors： Crichton NJ,Hinde JP,Marchini J

更新日期：1997-04-15 00:00:00

abstract：:To summarize safety data such as clinical adverse experiences in clinical trials with a moderate to long-term follow-up, we may use a measurement which accounts for the potential differences in the follow-up duration between treatment groups. The incidence rate, which uses the total person-time follow-up in a treatmen...

journal_title：Statistics in medicine

authors： Liu GF,Wang J,Liu K,Snavely DB

更新日期：2006-04-30 00:00:00

abstract：:Often in randomized clinical trials and observational studies in occupational and environmental health, a non-negative continuously distributed response variable denoting some metabolites of environmental toxicants is measured in treatment and control groups. When observations occur in both unexposed and exposed subje...

journal_title：Statistics in medicine

authors： Chu H,Nie L,Kensler TW

更新日期：2008-06-15 00:00:00

abstract：:A model is developed to estimate the effect of covariate imbalance on the size of a test of treatment efficacy in randomized clinical trials comparing two treatments when dispersion parameters are known. It is concluded that tests of homogeneity on the covariates should not be performed, that covariate imbalance is ju...

journal_title：Statistics in medicine

authors： Senn SJ

更新日期：1989-04-01 00:00:00

abstract：:Risk prediction models play an important role in prevention and treatment of several diseases. Models that are in clinical use are often refined and improved. In many instances, the most efficient way to improve a successful model is to identify subgroups for which there is a specific biological rationale for improvem...

journal_title：Statistics in medicine

authors： Biswas S,Arun B,Parmigiani G

更新日期：2014-05-20 00:00:00

abstract：:Clinical trials of treatments for rare or fatal diseases must often use historical rather than randomized concurrent controls. Randomized trials may not be possible if (1) the number of patients available is quite small, (2) ethical considerations discourage the assignment of patients to control treatments known to be...

journal_title：Statistics in medicine

authors： Hoehler FK,Mantel N,Gehan E,Kahana E,Alter M

更新日期：1984-07-01 00:00:00

abstract：:Statistical methods are available for performing a meta-analysis when the response variable of interest is the same in each study. Problems arise when studies exploring a common therapeutic question use different patient response types. This article presents statistical methods for combining studies which involve diff...

journal_title：Statistics in medicine

authors： Whitehead A,Jones NM

更新日期：1994-12-15 00:00:00

abstract：:Graphical methods are often used to check goodness-of-fit of models to data. It is common to plot residuals against a reference distribution so that when the model fits the data, the configuration should be close to a straight line. Since the resemblance to a straight line is often unclear, it has been suggested to ad...

journal_title：Statistics in medicine

authors： Cohen A,Barnett O

更新日期：1995-08-30 00:00:00

abstract：:A method is presented which allows us to adapt the sample size as well as the number and time points of interim analyses to the treatment difference observed at an interim look during the course of a clinical trial with censored survival time as the endpoint. The method allows the inclusion of data inspections during ...

journal_title：Statistics in medicine

authors： Schäfer H,Müller HH

更新日期：2001-12-30 00:00:00

abstract：:In a recent Statistics in Medicine paper, Warn, Thompson and Spiegelhalter (WTS) made a comparison between the Bayesian approach to the meta-analysis of binary outcomes and a popular Classical approach that uses summary (two-stage) techniques. They included approximate summary (two-stage) Bayesian techniques in their ...

journal_title：Statistics in medicine

authors： O'Rourke K,Altman DG

更新日期：2005-09-15 00:00:00

abstract：:Service on the Data Monitoring Committee of the CPEP (Calcium for Pre-eclampsia Prevention) has led us to four conclusions about clinical trials which we should like to present to this gathering of biostatisticians for their reactions: (i) meta-analyses of the pertinent published trials of the same therapy should alwa...

journal_title：Statistics in medicine

authors： Chalmers TC,Lau J

更新日期：1996-06-30 00:00:00

abstract：:The mixed effect models for repeated measures (MMRM) analysis is sometimes used as a primary analysis in longitudinal randomized clinical trials. The SE for the treatment effect in the MMRM analysis is usually estimated by assuming the orthogonality of the fixed effect and variance-covariance parameters, which is the ...

journal_title：Statistics in medicine

authors： Maruo K,Ishii R,Yamaguchi Y,Doi M,Gosho M

更新日期：2020-04-30 00:00:00

abstract：:Although there are many models which are used to calculate the health benefits (and thus the cost-effectiveness) of vaccination programmes, they can be divided into two groups: those which assume a constant force of infection, that is a constant per-susceptible rate of infection; and those which assume that the force ...

journal_title：Statistics in medicine

authors： Edmunds WJ,Medley GF,Nokes DJ

更新日期：1999-12-15 00:00:00

abstract：:The use of the continual reassessment method (CRM) and other model-based approaches to design Phase I clinical trials has increased owing to the ability of the CRM to identify the maximum tolerated dose better than the 3 + 3 method. However, the CRM can be sensitive to the variance selected for the prior distribution ...

journal_title：Statistics in medicine

authors： Zhang J,Braun TM,Taylor JM

更新日期：2013-06-15 00:00:00

abstract：:The Cochran-Armitage trend test has been used in case-control studies for testing genetic association. As the variance of the test statistic is a function of unknown parameters, e.g. disease prevalence and allele frequency, it must be estimated. The usual estimator combining data for cases and controls assumes they fo...

journal_title：Statistics in medicine

authors： Zheng G,Gastwirth JL

更新日期：2006-09-30 00:00:00

abstract：:In the analysis of composite endpoints in a clinical trial, time to first event analysis techniques such as the logrank test and Cox proportional hazard test do not take into account the multiplicity, importance, and the severity of events in the composite endpoint. Several generalized pairwise comparison analysis met...

journal_title：Statistics in medicine

authors： Verbeeck J,Spitzer E,de Vries T,van Es GA,Anderson WN,Van Mieghem NM,Leon MB,Molenberghs G,Tijssen J

更新日期：2019-12-30 00:00:00

abstract：:Mediation analysis is a standard approach to understanding how and why an intervention works in social and medical sciences. However, the presence of missing data, especially missing not at random data, poses a great challenge for the applicability of this approach in practice. Current methods for handling such missin...

journal_title：Statistics in medicine

authors： Li W,Zhou XH

更新日期：2017-11-10 00:00:00