Successful treatment with three-weekly paclitaxel of an anthracycline-refractory classical Kaposi's sarcoma.

abstract：:HAMAs (human anti mouse antibodies) in serum of patients may be stimulated as an immunologic reaction to the application of animal protein. They are differentiated into heterophilic (species-unspecific) and mouse-specific anti-isotypic (often IgG1) or-idiotypic antibodies as well as according to the human immunoglobul...

journal_title：Anticancer research

authors： Hasholzner U,Stieber P,Meier W,Lamerz R

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:S100(+) dendritic cells and CD57(+) lymphocytes are factors reflecting the immune system's ability to suppress the progress of tumor growth. CD57(+) cells include natural killer cells and late stages of T-effector lymphocytes. We evaluated the relationship between the known clinical and histological factors ...

journal_title：Anticancer research

authors： Liska V,Vycital O,Daum O,Novak P,Treska V,Bruha J,Pitule P,Holubec L

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Breast cancer (BC) is the most common cancer in women, and the hormone receptor status is one of the most important prognostic factors in patients with BC. The aim of this study was to establish whether a relationship exists between the hormone receptor rate and the main classic risk factors in patients with...

journal_title：Anticancer research

authors： Lumachi F,Ermani M,Marino F,Di Cristofaro L,Tombolan V,Brunello A,Roma A,Basso U

更新日期：2008-01-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that are vital to the proper development of the central nervous system. Their effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development...

journal_title：Anticancer research

authors： Radin DP,Patel P

更新日期：2017-08-01 00:00:00

abstract：:Cervical cancer is not considered a hormone-responsive tumor in spite of the presence of estrogen receptors (ER) and progesterone receptors (PgR) in some of them. Endocrine treatments have not achieved clinical responses, however, tamoxifen has been reported to induce PgR and to inhibit cell growth of many cervical ca...

journal_title：Anticancer research

authors： Vargas Roig LM,Lotfi H,Olcese JE,Lo Castro G,Ciocca DR

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:During the progression from low-grade dysplastic nodule (DN) to progressed hepatocellular carcinoma (HCC), intranodular portal tracts gradually disappear, while unpaired arteries develop increasingly. Contrast-enhanced ultrasound (CEUS) is highly accurate in depicting intranodular vascularity. This study eva...

journal_title：Anticancer research

authors： Giorgio A,Calisti G,di Sarno A,Farella N,de Stefano G,Scognamiglio U,Giorgio V

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The purpose of the present study was to correlate the nuclear expression of p53 and p21 with response to paclitaxel and carboplatin, progression-free survival (PFS) as well as overall survival (OS), in patients with urothelial metastatic transitional-cell carcinoma (TCC). PATIENTS AND METHODS:Histological s...

journal_title：Anticancer research

authors： Flamm M,Brodowicz T,Haitel A,Susani M,Tomek S,Köstler W,Pycha A,Kratzik C,Marberger M,Zielinski CC

更新日期：2002-03-01 00:00:00

abstract：:The results of palliative chemotherapy in 162 patients suffering from exocrine pancreatic cancer are presented. They are mainly discussed with respect to the possibility of improving survival of exocrine pancreatic cancer patients by an efficacy-orientated sequential polychemotherapy (EOSP). In about 40% of the patien...

journal_title：Anticancer research

authors： Klapdor R,Bahlo M,Babinski A,Broemel T,Müller C,Seutter R

更新日期：2003-03-01 00:00:00

abstract：:Our recent in vitro findings for suppression of thrombospondin-1 (TSP1; an antiangiogenic factor) expression by wild-type (wt) p53 in a p53-null thyroid carcinoma cell line, FRO, prompted us to investigate the in vivo effect of exogenous wt-p53 and TSP1 expression on tumor growth and angiogenesis of FRO xenografts in ...

journal_title：Anticancer research

authors： Nagayama Y,Shigematsu K,Namba H,Zeki K,Yamashita S,Niwa M

更新日期：2000-07-01 00:00:00

abstract：:The antitumor effects of "half-mustard type" phenothiazines were studied on 57 different tumor cell lines, including leukemias, non-small lung cancer, colon, central nervous system, ovarian, renal, breast, and prostate cancer, as well as melanoma cell cultures. Alkyl-urea derivatives of phenothiazines displayed in vit...

journal_title：Anticancer research

authors： Wuonola MA,Palfreyman MG,Motohashi N,Kawase M,Gabay S,Nacsa J,Molnár J

更新日期：1997-09-01 00:00:00

abstract：:This review focuses on the functional role and structural features of the genes involved in common hereditary cancers. Most of these tumors are sporadic and the genetic alterations responsible for their genesis take place over several cell generations; nevertheless, 5 to 10% of the human tumors are hereditary, with a ...

journal_title：Anticancer research

authors： Russo A,Zanna I,Tubiolo C,Migliavacca M,Bazan V,Latteri MA,Tomasino RM,Gebbia N

更新日期：2000-11-01 00:00:00

abstract：:AD 198, a novel lipophilic N-alkyl derivative of adriamycin (ADR) and a potential anticancer agent for preclinical development, was studied for its effects on the activities of DNA and RNA polymerases in vitro and its ability to bind DNA. AD 198, which contains a benzyl substituent on the glycosidic amine, was found t...

journal_title：Anticancer research

authors： Lameh J,Chuang LF,Israel M,Chuang RY

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND/AIM:The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS:MT-I/II and Ki-67 antigen expression was studie...

journal_title：Anticancer research

authors： Domoslawski P,Pula B,Olbromski M,Wojtczak B,Lukienczuk T,Podhorska-Okolow M,Dziegiel P

更新日期：2018-12-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E and HLA-F are classified as non-classical HLA class Ib antigens. Ectopic HLA-E and HLA-F expression was recently detected in cancer cells; however, the clinical implication of their expression remains unknown. A total of 209 patients with gastric cancer were enrolled in this study. Immu...

journal_title：Anticancer research

authors： Ishigami S,Arigami T,Okumura H,Uchikado Y,Kita Y,Kurahara H,Maemura K,Kijima Y,Ishihara Y,Sasaki K,Uenosono Y,Natsugoe S

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND/AIM:Metabolomics is widely used for biomarker discovery, but conventional mass-spectrometry extraction procedures lose the spatial localization of metabolites. In this study, we directly analyzed breast carcinoma tissues embedded in frozen tissue microarrays (fTMAs) using MALDI mass-spectrometry imaging (MAL...

journal_title：Anticancer research

authors： Torata N,Kubo M,Miura D,Ohuchida K,Mizuuchi Y,Fujimura Y,Hayakawa E,Kai M,Oda Y,Mizumoto K,Hashizume M,Nakamura M

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:Autophagy can be either tumor promotive or suppressive. We previously identified an autophagy-inducing activity in the 30-100 kDa fraction of areca-nut-extract (ANE 30-100K) and showed that several tumor cells subjected to chronic ANE 30-100K stimulation (CAS) exhibited higher resistance against stressed...

journal_title：Anticancer research

authors： Chiu CT,Liu SY,Yen CY,Liu BY,Sun ZY,Wu CY,Deng JL,Liu YC,Lin MH

更新日期：2020-01-01 00:00:00

abstract：UNLABELLED:The aim of the present study was to investigate hypoxia-inducible factor 1α (HIF-1α) and glucose transporter-1 (GLUT-1) expressions as predictors of response and survival after chemoradiotherapy in pretreatment biopsy specimens from patients with rectal cancer. MATERIALS AND METHODS:The immunohistological e...

journal_title：Anticancer research

authors： Havelund BM,Sørensen FB,Lindebjerg J,Spindler KL,Jakobsen A

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND/AIM:Tyrosine kinase inhibitors are important in the treatment of metastatic renal cell cancer (mRCC). The aim of the study was to evaluate the costs and effects of sunitinib in mRCC. PATIENTS AND METHODS:A total of 81 mRCC patients who received first-line sunitinib therapy between 2010 and 2014 were recruit...

journal_title：Anticancer research

authors： Vuorinen RL,Paunu N,Turpeenniemi-Hujanen T,Reunamo T,Jekunen A,Kataja V,Sintonen H,Purmonen T,Kellokumpu-Lehtinen PL

更新日期：2019-10-01 00:00:00

abstract：:Although several chemical carcinogenes have been shown to induce malignant transformation in human cells in culture, the molecular events involved in conversion of normal cells to malignant cells remain unknown at present. Normal human cells seem to be resistant to transformation by a single oncogene unless these cell...

journal_title：Anticancer research

authors： Khoobyarian N,Marczynska B

更新日期：1989-09-01 00:00:00

abstract：:The usefulness of prostate specific antigen (PSA) in screening for prostatic carcinoma was studied in 262 inpatients of the department of internal medicine. All patients underwent a rectal digital examination and determination of PSA by the Tandem-E method (Hybritech). The plan was to perform biopsies if there were su...

journal_title：Anticancer research

authors： Waidelich R,Jansen HM,Stieber P,Schmeller N,Lamerz R,Werdan K,Fateh-Moghadam A

更新日期：1997-07-01 00:00:00

abstract：:The effects of a bacterial vaccine, heat-killed Clostridium butyricum MII 588 cells, on the metastasis of B16-F10 melanoma in BDF1 mice was investigated. The vaccine stimulated natural killer (NK) cell cytotoxic activity against YAC-1 target cells, which peaked at 72 hr after the pretreatment, whereas maximum macropha...

journal_title：Anticancer research

authors： Chen HY,Wu SL,Yeh MY,Chen CF,Mikami Y,Wu JS

更新日期：1993-01-01 00:00:00

abstract：:The p53 gene product suppresses both tumor cell growth and the cellular transformation process promoted by oncogenes. Although several genes are known to be positively regulated by p53, it is unclear how many gene expression events are involved in p53-mediated growth arrest and apoptosis. Two-dimensional gel electroph...

journal_title：Anticancer research

authors： Maxwell SA

更新日期：1994-11-01 00:00:00

abstract：:Mutations affecting the mechanistic target of rapamycin (MTOR) signalling pathway are frequent in human cancer and have been identified in up to 15% of pancreatic neuroendocrine tumours (NETs). Grade A evidence supports the efficacy of MTOR inhibition with everolimus in pancreatic NETs. Although a significant proporti...

journal_title：Anticancer research

authors： Backman S,Norlén O,Eriksson B,Skogseid B,Stålberg P,Crona J

更新日期：2017-02-01 00:00:00

abstract：:The dimers bis-EUG, bis-MMP, bis-BHA, bis-BMP and bis-DBP were synthesized from the monomers 4-allyl-2-methoxyphenol (EUG), 2-methoxy-4-methylphenol (MMP), 2-t-butyl-4-methoxyphenol (BHA), 2-t-butyl-4-methylphenol (BMP) and 2,4-di-t-butylphenol (DBP), respectively. The stoichiometric factors (n; number of free radical...

journal_title：Anticancer research

authors： Fujisawa S,Atsumi T,Kadoma Y,Ishihara M,Ito S,Yokoe I

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:In 1979, Montgomery and Asberg introduced an inventory for screening of depression. To our knowledge, the associations between the MADRS and the risk of breast cancer (BC) are rarely considered together in a prospective study. PATIENTS AND METHODS:In an extension of the Kuopio Breast Cancer Study, 115 women...

journal_title：Anticancer research

authors： Eskelinen M,Ollonen P

更新日期：2011-03-01 00:00:00

abstract：:We have previously shown that L-glutamic acid gamma-monohydroxamate (GAH) exhibits an antitumor activity, both in vitro and in vivo. In this report we explore the selective cytotoxicity of GAH in vitro by comparing the survival of tumor and normal cells. GAH exerts an irreversible delayed effect with tumoral cells and...

journal_title：Anticancer research

authors： Thomasset N,Chabanas A,Tournaire R,Malley S,Navarro C,Lawrence JJ,Doré JF,Vila J

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND/AIM:Magnetic resonance (MR) and ultrasound (US) fusion imaging (MR-US fusion) is already used to guide prostate biopsies and has been proven accurate for diagnosing cervical cancer. In this study, we aimed to evaluate the feasibility and performance of MR-US fusion for characterizing adnexal masses. PATIENT...

journal_title：Anticancer research

authors： Crestani A,Theodore C,Levaillant JM,Thomassin-Naggara I,Skalli D,Miaihle G,Dabi Y,Haddad B,Touboul C

更新日期：2020-07-01 00:00:00

abstract：:The possible influence of continuous dietary treatment with 15% inulin or oligofructose on the development of lung metastases of a transplantable liver tumor in young male C3H mice was investigated. Microscopical examination demonstrated a distinct inhibitory effect of this dietary treatment on the development of lung...

journal_title：Anticancer research

authors： Taper HS,Roberfroid MB

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:We investigated whether GM-CSF/IL-4 is the most efficient cytokine combination for differentiating dendritic cells (DC) in terms of its ability to elicit an antitumor immune response. MATERIALS AND METHODS:Two experimental models were examined: C57BL/6 mice bearing MC38 cells and Balb/c mice bearing cachexi...

journal_title：Anticancer research

authors： Hikino H,Kasono K,Kanzaki M,Kai T,Konishi F,Kawakami M

更新日期：2004-05-01 00:00:00

abstract：:We have established a practical system for generating antitumor effector lymphocytes using the tumor antigen peptide CEA and cultured dendritic cells (DCs), and have also characterized effector cells. DCs were induced from the adherent cell population of autologous peripheral blood mononuclear cells (PBMCs) obtained f...

journal_title：Anticancer research

authors： Ohta K,Yamaguchi Y,Shimizu K,Miyahara E,Toge T

更新日期：2002-09-01 00:00:00