Abstract:
OBJECTIVE:Periodontitis increases the serum lipopolysaccharide level, contributing to liver injury. Toothbrushing improves periodontitis and may also affect serum lipopolysaccharide concentration and periodontitis-induced liver injury. The purpose of the present study was to examine whether the improvement in periodontal inflammation by toothbrushing clinically affects the serum lipopolysaccharide level and hepatic pathological changes in rat periodontitis. MATERIAL AND METHODS:Thirty male Wistar rats were divided into 5 groups, 2 groups receiving topical application of pyrogen-free water to the gingival sulcus for 4 or 8 weeks. The next 2 groups received topical application of lipopolysaccharide and proteases for 4 or 8 weeks. The last group received topical application of lipopolysaccharide and proteases for 8 weeks, and the palatal gingiva was brushed with a powered toothbrush once a day for 4 weeks prior to the end of the experimental period. RESULTS:Topical application of lipopolysaccharide and proteases induced not only periodontal inflammation but also an elevation in the serum lipopolysaccharide concentration, with increasing hepatic inflammation, steatosis and 8-hydroxydeoxyguanosine levels in a time-dependent manner. The rats that received gingival stimulation showed decreased polymorphonuclear leukocyte infiltration and collagen loss levels in the periodontal lesions. Furthermore, this group also showed a decrease in serum lipopolysaccharide concentration and hepatic inflammation, steatosis and 8-hydroxydeoxyguanosine levels, compared with the group receiving no treatment. CONCLUSIONS:Toothbrushing promoted healing of periodontal lesions, decreased serum lipopolysaccharide concentration and suppressed liver injury in a rat periodontitis model.
journal_name
Acta Odontol Scandjournal_title
Acta odontologica Scandinavicaauthors
Tomofuji T,Ekuni D,Sanbe T,Azuma T,Tamaki N,Irie K,Maruyama T,Yamamoto T,Watanabe T,Miyauchi M,Takata Tdoi
10.1080/00016350902794818subject
Has Abstractpub_date
2009-01-01 00:00:00pages
200-5issue
4eissn
0001-6357issn
1502-3850pii
909707762journal_volume
67pub_type
杂志文章abstract::The aim of this study was to determine dental health status in two separate groups of Chilean and Polish refugees in Sweden. In Scandinavia, Sweden has the largest number of immigrants--1 million out of a population of 8.3 million. Since 1975, most immigrants have been refugees and their families. During 1978-82 Swede...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016358809004742
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abstract::A method to analyse cephalometric radiographs with the help of a computer has been described. With the system a cephalometric radiograph can be analysed and the results compared to corresponding analyses of individuals with ideal occlusion. The results can also be visualized as schematic figures of the patients. The c...
journal_title:Acta odontologica Scandinavica
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doi:10.3109/00016357809029087
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abstract:OBJECTIVE:The aim of this study was to investigate the effect of a specific therapeutic jaw exercise on the temporomandibular disorders of patients with chronic whiplash-associated disorders. MATERIAL AND METHODS:Ninety-four consecutive patients with whiplash-related conditions were referred to and accepted for a trea...
journal_title:Acta odontologica Scandinavica
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016358709097536
更新日期:1987-08-01 00:00:00
abstract::Errors in questionnaire surveys are usually of one of two sources: non-responses or incorrect answers. The aim was to investigate the validity of a questionnaire survey and to estimate the respective bias of these answers. Of 9,283 subjects selected to receive a questionnaire by post, 3,949 (43%) responded, and, of th...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.1080/000163599428643
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pub_type: 杂志文章
doi:10.3109/00016357.2011.654258
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
abstract::Objective: This study evaluated human leucocyte antigen-G gene polymorphisms in patients with periodontitis and healthy controls.Material and methods: The insertion/deletion polymorphism of 14 bp and a single nucleotide polymorphism (SNP) C > G on the position +3142 of the 3' untranslated region of the gene were analy...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
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journal_title:Acta odontologica Scandinavica
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更新日期:2007-06-01 00:00:00
abstract::This study aimed at determining alveolar bone height in musicians playing wind instruments and non-wind instruments. Two hundred and forty-two subjects, 208 men and 34 women, from 3 national orchestras in Stockholm were examined in an intraoral full-mouth survey. The height of alveolar bone, registered by a computeriz...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016358609026566
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016350903281740
更新日期:2010-01-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The present study was made to investigate the effect of xylitol on the bactericidal and bacteriostatic action of chlorohexidine diacetate (CHX) and sodium fluoride (F) in ATCC strains of Streptococcus mutans and S. sanguis. Standardized bacterial cell suspensions were used in tests for bactericidal effect and for inhi...
journal_title:Acta odontologica Scandinavica
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doi:10.3109/00016359309041155
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journal_title:Acta odontologica Scandinavica
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doi:10.3109/00016357.2013.879996
更新日期:2014-11-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016357909004701
更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/00016357.2012.715197
更新日期:2013-05-01 00:00:00
abstract::Ceramic inlays offer a good alternative to posterior composites, which still show a high polymerization shrinkage. The thin cement layer will reduce the total amount of shrinkage and probably result in a better marginal adaptation and decreased marginal leakage. Fired feldspathic ceramic inlays cemented with either a ...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016359409027588
更新日期:1994-06-01 00:00:00
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更新日期:2000-10-01 00:00:00
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journal_title:Acta odontologica Scandinavica
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journal_title:Acta odontologica Scandinavica
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016359609003538
更新日期:1996-10-01 00:00:00
abstract::The present study describes a Swedish family in which the mother and her son were affected with signs of popliteal pterygium syndrome (PPS, OMIM 119500). Both individuals had bilateral complete cleft lip and palate, oral synechiae, paramedian pits on the lower lip, toe syndactyly and a piece of triangular skin overgro...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.1080/000163500429334
更新日期:2000-04-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016357.2014.903518
更新日期:2014-11-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016357.2015.1090011
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:The Icelandic Sagas are an important source of information on the way of life and diet habits in Iceland and possibly other Nordic countries 1000 years ago. Archaeological human skull material worldwide has revealed extensive tooth wear, with the main cause believed to be coarse diet. From a graveyard near v...
journal_title:Acta odontologica Scandinavica
pub_type: 历史文章,杂志文章
doi:10.3109/00016357.2015.1075586
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Non-human primates, dogs, rats, hamsters and ferrets, have frequently been used as laboratory animals in periodontal biology and pathology. In the past, mice have been used less for this purpose, but nowadays attract a lot of interest because gene knockout and transgenic technologies utilize mice primarily. I...
journal_title:Acta odontologica Scandinavica
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doi:10.1080/00016350802443474
更新日期:2009-01-01 00:00:00
abstract::The use of permanent magnets in orthodontic treatment has increased significantly over the past years, triggered by the introduction of rare earth magnetic alloys. Concerns about possible side effects have been expressed relating to their use in orthodontic treatment. In previous experimental studies evidence of a red...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016359509005983
更新日期:1995-08-01 00:00:00
abstract::The aim of this epidemiological study was to examine associations between temporomandibular (TMD)-related problems and variables from three domains: (1) socio-economic attributes, (2) general health and health-related lifestyle, and (3) dental attitudes and behaviors. The overall response rate to a questionnaire maile...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016350410001649
更新日期:2004-08-01 00:00:00
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doi:10.1080/00016357.2018.1465995
更新日期:2018-08-01 00:00:00