Abstract：
:Di-n-butyl phthalate (DBP) is a ubiquitous environmental pollutant, extensively used as a softener for polyvinyl chloride resins. A study was conducted to evaluate its effect on reproductive function of Wistar rats. DBP was given orally at a dose of 500, 1000 and 1500 mg kg(-1) body weight for 7 days. Evaluating histological and fertility parameters assessed reproductive function. Significant reduction in seminiferous tubule diameter, Leydig cell nuclear diameter (except at dose 500 mg), number of primary spermatocytes, secondary spermatocytes and spermatids were observed. Caudal sperm density and viability reduced significantly. Decrease in serum testosterone was also observed. Evidence indicates that DBP exposure causes dose dependent testicular toxicity and has the potential to induce adverse effect.
journal_name
J Environ Bioljournal_title
Journal of environmental biologyauthors
Nair N,Bedwal S,Kumari D,Bedwal S,Bedwal RSsubject
Has Abstractpub_date
2008-09-01 00:00:00pages
769-72issue
5eissn
0254-8704issn
2394-0379journal_volume
29pub_type
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