Abstract:
:Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV is a rare, autosomal recessive neurologic disorder, characterized by absence of reaction to painful stimuli, mental retardation, self- mutilating behavior, anhidrosis, and recurrent episodes of hyperthermia. Mutations in the neurotrophic tyrosine kinase receptor 1, a receptor phosphorylated by nerve growth factor, have been documented in diverse ethnic groups. We identified the same novel nonsense mutation in two unrelated families of Moroccan Jewish descent, each with two affected siblings. This possible founder mutation may trace to the rural Jewish village in southern Morocco from where both these families originated. Genetic screening for the causative mutation among 300 unrelated Moroccan Jews did not reveal carriers for the causative mutation, thus excluding high risk for CIPA in this ethnic subpopulation.
journal_name
Clin Genetjournal_title
Clinical geneticsauthors
Suriu C,Khayat M,Weiler M,Kfir N,Cohen C,Zinger A,Aslanidis C,Schmitz G,Falik-Zaccai TCdoi
10.1111/j.1399-0004.2008.01143.xsubject
Has Abstractpub_date
2009-03-01 00:00:00pages
230-6issue
3eissn
0009-9163issn
1399-0004pii
CGE1143journal_volume
75pub_type
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