Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort.


:Women with reduced CYP2D6 activity have low endoxifen concentrations and likely worse long term benefits from tamoxifen. We investigated the association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. We collected hot flash frequency and severity data over 12 months from 297 women initiating tamoxifen. We performed CYP2D6 genotyping using the AmpliChip CYP450 test and correlated inherited genetic polymorphisms in CYP2D6 and tamoxifen-induced hot flashes. Intermediate metabolizers had greater mean hot flash scores after 4 months of tamoxifen therapy (44.3) compared to poor metabolizers (20.6, P = 0.038) or extensive metabolizers (26.9, P = 0.011). At 4 months, we observed a trend toward fewer severe hot flashes in poor metabolizers compared to intermediate plus extensive metabolizers (P = 0.062). CYP2D6 activity may be a modest predictive factor for tamoxifen-induced hot flashes. The presence or absence of hot flashes should not be used to determine tamoxifen's efficacy.


Henry NL,Rae JM,Li L,Azzouz F,Skaar TC,Desta Z,Sikora MJ,Philips S,Nguyen AT,Storniolo AM,Hayes DF,Flockhart DA,Stearns V,Consortium on Breast Cancer Pharmacogenomics Investigators.




Has Abstract


2009-10-01 00:00:00












  • Activation of mitochondrial unfolded protein response is associated with Her2-overexpression breast cancer.

    abstract:PURPOSE:Mitochondrial unfolding protein are abundant in breast cancer cells, but the mechanism by which breast cancer cells resist apoptosis is still not fully elucidated. In this study, we explored the role of mitochondrial unfolded protein response (mtUPR)-related proteins in four types of breast cancer tissues. MET...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Chen FM,Huang LJ,Ou-Yang F,Kan JY,Kao LC,Hou MF

    更新日期:2020-08-01 00:00:00

  • Estrogen receptor alpha polymorphisms and postmenopausal breast cancer risk.

    abstract:BACKGROUND:The estrogen receptor alpha (ESR1) is a mediator of estrogen response in the breast. The most studied variants in this gene are the PvuII and XbaI polymorphisms, which have been associated to lower sensitivity to estrogen. We evaluated whether these polymorphisms were associated with breast cancer risk by me...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: González-Zuloeta Ladd AM,Vásquez AA,Rivadeneira F,Siemes C,Hofman A,Stricker BH,Pols HA,Uitterlinden AG,van Duijn CM

    更新日期:2008-02-01 00:00:00

  • Bevacizumab in metastatic breast cancer: a meta-analysis of randomized controlled trials.

    abstract::Numerous studies have demonstrated that angiogenesis and in particular VEGF over-expression play an essential role in the progression and metastatic potential of breast cancer. Bevacizumab is a humanized recombinant monoclonal antibody that specifically blocks the binding of VEGF to high-affinity receptors and it has ...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,meta分析,评审


    authors: Valachis A,Polyzos NP,Patsopoulos NA,Georgoulias V,Mavroudis D,Mauri D

    更新日期:2010-07-01 00:00:00

  • Re-interpretation of PAM50 gene expression as quantitative tumor dimensions shows utility for clinical trials: application to prognosis and response to paclitaxel in breast cancer.

    abstract:BACKGROUND:We recently showed PAM50 gene expression data can be represented by five quantitative, orthogonal, multi-gene breast tumor traits. These novel tumor 'dimensions' were superior to categorical intrinsic subtypes for clustering in high-risk breast cancer pedigrees, indicating potential to represent underlying g...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Camp NJ,Madsen MJ,Herranz J,Rodríguez-Lescure Á,Ruiz A,Martín M,Bernard PS

    更新日期:2019-05-01 00:00:00

  • Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer.

    abstract:PURPOSE:Although breast cancer in young women accounts for <10% of diagnoses annually, tumors in young patients exhibit more aggressive characteristics and higher mortality rates. Determination of the frequency of germline mutations in cancer predisposition genes is needed to improve the understanding of breast cancer ...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Rummel SK,Lovejoy L,Shriver CD,Ellsworth RE

    更新日期:2017-08-01 00:00:00

  • Pharmacology of aminoglutethimide: structure/activity relationships and receptor interactions.

    abstract::The structure/activity relationships for inhibition of aromatase and cholesterol side-chain cleavage enzyme (CSCC) by aminoglutethimide and some of its analogues are reviewed. Although more effective against aromatase than CSCC, aminoglutethimide markedly inhibits both enzymes. Optimal competitive antagonism of aromat...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Nicholls PJ,Daly MJ,Smith HJ

    更新日期:1986-01-01 00:00:00

  • Assessing the additional surgical risk of contralateral prophylactic mastectomy and immediate breast implant reconstruction.

    abstract:INTRODUCTION:There has been a sharp rise in the rate of contralateral prophylactic mastectomy over the last decade, despite the low incidence of new primary cancers predicted for the contralateral breast. This study compares the postoperative complication rates between the diseased breast treated with mastectomy and th...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Nealon KP,Sobti N,Gadd M,Specht M,Liao EC

    更新日期:2020-01-01 00:00:00

  • The 17q23 amplicon and breast cancer.

    abstract::A novel region of amplification in breast tumors was recently identified on chromosome 17q23. Extensive mapping of the amplicon by Southern blotting and fluorescence in situ hybridization (FISH) in breast cancer cell lines determined that the amplicon can be up to 4 Mbp in size and may contain 50 genes. Copy number an...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,评审


    authors: Sinclair CS,Rowley M,Naderi A,Couch FJ

    更新日期:2003-04-01 00:00:00

  • Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer.

    abstract::The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provi...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Mu Z,Wang C,Ye Z,Austin L,Civan J,Hyslop T,Palazzo JP,Jaslow R,Li B,Myers RE,Jiang J,Xing J,Yang H,Cristofanilli M

    更新日期:2015-12-01 00:00:00

  • Amplifications of oncogene erbB-2 and chromosome 20q in breast cancer determined by differentially competitive polymerase chain reaction.

    abstract::A new method of measuring gene copy number in small samples of DNA was used to measure amplification of the erbB-2 gene and of chromosome 20q in breast cancer. This method, termed 'differentially competitive polymerase chain reaction' (DC-PCR) combines the advantages of two other techniques for measuring amplification...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Deng G,Yu M,Chen LC,Moore D,Kurisu W,Kallioniemi A,Waldman FM,Collins C,Smith HS

    更新日期:1996-01-01 00:00:00

  • Progesterone receptors and human breast cancer.

    abstract::Estrogen receptor protein is known to be an important prognostic factor for patients with breast cancer. The presence of estrogen receptor correlates with response to endocrine therapy in patients with metastatic disease and is associated with prolonged disease-free and overall survival in patients with primary diseas...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,评审


    authors: Clark GM,McGuire WL

    更新日期:1983-01-01 00:00:00

  • Chemotherapy for metastatic breast cancer. Comparison of clinical practice and cost of drugs in two cohorts of patients: 1994-1998 and 2003-2006.

    abstract::Although new chemotherapeutic drugs for metastatic breast cancer (MBC) have been approved over the past decade, it is unclear whether this has changed the overall outcome of patients. This study assessed the clinical and economic impacts of these drugs. We retrospectively studied MBC patients receiving chemotherapy in...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Galy G,Labidi-Galy SI,Perol D,Bachelot T,Ray-Coquard I,Tredan O,Biron P,Latour JF,Blay JY,Guastalla JP,Favier B

    更新日期:2011-07-01 00:00:00

  • Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue.

    abstract::The purpose of the present study was to characterize primitive epithelial progenitor populations present in adult normal human mammary tissue using a combination of flow cytometry and in vitro colony assay procedures. Three types of human breast epithelial cell (HBEC) progenitors were identified: luminal-restricted, m...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Stingl J,Eaves CJ,Zandieh I,Emerman JT

    更新日期:2001-05-01 00:00:00

  • Smoking and survival after breast cancer diagnosis: a prospective observational study and systematic review.

    abstract::The association of smoking with outcomes following breast cancer prognosis is not well understood. In a cohort study called Life After Cancer Epidemiology (LACE), 2,265 women diagnosed with breast cancer were followed for a median of 12 years. We used multivariable proportional-hazards models to determine whether smok...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,评审


    authors: Braithwaite D,Izano M,Moore DH,Kwan ML,Tammemagi MC,Hiatt RA,Kerlikowske K,Kroenke CH,Sweeney C,Habel L,Castillo A,Weltzien E,Caan B

    更新日期:2012-11-01 00:00:00

  • Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients.

    abstract:BACKGROUND:Adjuvant therapy decisions may be partly based on the results of a multigene quantitative reverse transcription-polymerase chain reaction (RT-PCR)-based assay: the 21-gene recurrence score (RS) test of resection specimens. When necessary, core needle biopsy (CNB) may be considered as a surrogate. Here, we ev...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Qi P,Yang Y,Bai QM,Xue T,Ren M,Yao QL,Yang WT,Zhou XY

    更新日期:2021-01-13 00:00:00

  • Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients.

    abstract::The association between promoter methylation status and survival was investigated in a large cohort of women with breast cancer, participants in the Long Island Breast Cancer Study Project. Archived tumor tissues (n = 839) were collected from women diagnosed with a first primary invasive or in situ breast cancer in 19...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Cho YH,Shen J,Gammon MD,Zhang YJ,Wang Q,Gonzalez K,Xu X,Bradshaw PT,Teitelbaum SL,Garbowski G,Hibshoosh H,Neugut AI,Chen J,Santella RM

    更新日期:2012-01-01 00:00:00

  • Survival analysis of censored data: neural network analysis detection of complex interactions between variables.

    abstract::Neural networks can be used as pattern recognition systems in complex data sets. We are exploring their utility in performing survival analysis to predict time to relapse or death. This technique has the potential to find easily some types of very complex interactions in data that would not be easily recognized by con...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: De Laurentiis M,Ravdin PM

    更新日期:1994-01-01 00:00:00

  • Effect of social housing condition on heat shock protein (HSP) expression in the Shionogi mouse mammary carcinoma (SC115).

    abstract::Our previous studies have shown that social housing conditions can significantly alter the growth rate of the Shionogi mouse mammary carcinoma (SC115). The present study extended our investigations to the molecular level by examining stressor effects on the expression of a group of stress-responsive proteins, the heat...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Andrews HN,Kerr LR,Strange KS,Emerman JT,Weinberg J

    更新日期:2000-02-01 00:00:00

  • A phase II trial of cyclophosphamide, epirubicin and vinorelbine in the treatment of advanced breast cancer.

    abstract:BACKGROUND:Vinorelbine (Navelbin; N) has proven to be active in patients with advanced breast cancer (ABC) and cyclophosphamide (C) and epirubicin (Epiadriamycin: E) are still among the main cytostatic agents against this tumor. On this basis was carried out a study to determine the activity and toxicity of the combina...

    journal_title:Breast cancer research and treatment

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Esteban E,de Sande G,Puertas J,Fra J,Palacio I,Vieitez JM,Fernández JL,Muñiz I,Modollel A,Carrasco J,Sala M,Lacave AJ

    更新日期:2000-07-01 00:00:00

  • Histone acetylation decreased by estradiol in the MCF-7 human mammary cancer cell line.

    abstract::The effect of estradiol (E2) on the [3H]-acetylation of nuclear histones was studied in the MCF-7 human mammary cancer cell line in culture. Cells (approximately 10(8) were incubated with 8 x 10(-6) M [3H]-acetate in the absence (control) or in the presence of estradiol (10(-5)-10(-8) M). After 20 min incubation, the ...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Pasqualini JR,Mercat P,Giambiagi N

    更新日期:1989-10-01 00:00:00

  • Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells.

    abstract::Aberrant expressions of the neuronal protein synuclein gamma (SNCG) in malignant mammary epithelial cells are strongly associated with the progression of breast cancer. SNCG is not expressed in normal breast tissues but abundantly expressed in a high percentage of invasive and metastatic breast carcinomas. Several stu...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Inaba S,Li C,Shi YE,Song DQ,Jiang JD,Liu J

    更新日期:2005-11-01 00:00:00

  • The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer.

    abstract:PURPOSE:To compare the prognostic significance of proliferation, as assessed by Ki67 expression, in breast cancer before and after neoadjuvant chemotherapy. METHODS:A retrospective search of a prospectively maintained clinical database was performed to identify patients treated with neoadjuvant chemotherapy at the Roy...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Jones RL,Salter J,A'Hern R,Nerurkar A,Parton M,Reis-Filho JS,Smith IE,Dowsett M

    更新日期:2009-07-01 00:00:00

  • Relationship between estrogen receptors and risk factors of breast cancer in Japanese pre- and postmenopausal patients.

    abstract::The relation between estrogen receptors (ER) in breast cancer and risk factors was studied in 456 Japanese patients. ER was shown to be positive in 55.3% (252/456) of patients. There was no difference in ER positivity between pre- and postmenopausal patients. In premenopausal patients, only the age at menarche and obe...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Nomura Y,Tashiro H,Hamada Y,Shigematsu T

    更新日期:1984-01-01 00:00:00

  • Transforming growth factor-beta in breast cancer: a working hypothesis.

    abstract::Transforming Growth Factor-beta (TGF beta) is the most potent known inhibitor of the progression of normal mammary epithelial cells through the cell cycle. During the early stages of breast cancer development, the transformed epithelial cells appear to still be sensitive to TGF beta-mediated growth arrest, and TGF bet...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,评审


    authors: Reiss M,Barcellos-Hoff MH

    更新日期:1997-08-01 00:00:00

  • A scoping review characterizing "Choosing Wisely®" recommendations for breast cancer management.

    abstract:PURPOSE:Choosing Wisely (CW)® was created by the American Board of Internal Medicine (ABIM) to promote patient-physician conversations about unnecessary medical interventions. Similarly, other countries created their own panels of experts called "CW® campaigns" which review recommendations submitted by that country's o...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,评审


    authors: Shah H,Surujballi J,Awan AA,Hutton B,Arnaout A,Shorr R,Vandermeer L,Alzahrani MJ,Clemons M

    更新日期:2020-11-06 00:00:00

  • Clinical and analytical validation of Ki-67 in 9069 patients from IBCSG VIII + IX, BIG1-98 and GeparTrio trial: systematic modulation of interobserver variance in a comprehensive in silico ring trial.

    abstract:PURPOSE:Ki-67 has been clinically validated for risk assessment in breast cancer, but the analytical validation and cutpoint-definition remain a challenge. Intraclass correlation coefficients (ICCs) are a statistical parameter for Ki-67 interobserver performance. However, the maximum degree of variance among pathologis...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Denkert C,Budczies J,Regan MM,Loibl S,Dell'Orto P,von Minckwitz G,Mastropasqua MG,Solbach C,Thürlimann B,Mehta K,Blohmer JU,Colleoni M,Müller V,Klauschen F,Ataseven B,Engels K,Kammler R,Pfitzner BM,Dietel M,Fasching

    更新日期:2019-08-01 00:00:00

  • The presence of serum anti-p53 antibodies from patients with invasive ductal carcinoma of breast: correlation to other clinical and biological parameters.

    abstract::Breast cancer has been the most common malignant tumor among women in many large cities of China. The aim of this study was to clarify the prognostic significance of serum anti-p53 antibodies (p53 Abs) in Chinese patients of breast cancer. One hundred and forty-four patients with invasive ductal carcinoma of breast we...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Gao RJ,Bao HZ,Yang Q,Cong Q,Song JN,Wang L

    更新日期:2005-09-01 00:00:00

  • Thrombocytosis as a prognostic factor in inflammatory breast cancer.

    abstract:PURPOSE:Platelets are essential components of hemostasis and also play an important role in the tumor microenvironment. The purposes of our research were to examine the role of thrombocytosis in inflammatory breast cancer (IBC) and to know which cytokine drives thrombocytosis. METHODS:We reviewed the medical records o...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Harano K,Kogawa T,Wu J,Yuan Y,Cohen EN,Lim B,Reuben JM,Ueno NT

    更新日期:2017-12-01 00:00:00

  • Association between CYP19 polymorphisms and breast cancer risk: results from 10,592 cases and 11,720 controls.

    abstract::The association of CYP19 gene polymorphisms with breast cancer has been widely reported, but results of previous studies were somewhat contradictory and underpowered. In order to overcome the limitations of individual study and to understand the real situation, we conducted a systematic review and meta-analysis includ...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,meta分析,评审


    authors: Ma X,Qi X,Chen C,Lin H,Xiong H,Li Y,Jiang J

    更新日期:2010-07-01 00:00:00

  • BRCA1 and BRCA2 mutation carriers in the Breast Cancer Family Registry: an open resource for collaborative research.

    abstract::The Breast Cancer Family Registry is a resource for interdisciplinary and translational studies of the genetic epidemiology of breast cancer. This resource is available to researchers worldwide for collaborative studies. Herein, we report the results of testing for germline mutations in BRCA1 and BRCA2. We have tested...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Neuhausen SL,Ozcelik H,Southey MC,John EM,Godwin AK,Chung W,Iriondo-Perez J,Miron A,Santella RM,Whittemore A,Andrulis IL,Buys SS,Daly MB,Hopper JL,Seminara D,Senie RT,Terry MB,Breast Cancer Family Registry.

    更新日期:2009-07-01 00:00:00