Abstract:
:Estrogen receptor alpha (ERalpha) activity is regulated by phosphorylation at several sites. Recently several antibodies specific for individual phosphorylated sites within ERalpha have became available. Such antibodies potentially provide invaluable tools to gain insight into the relevance in vivo of phosphorylated ERalpha in human breast tumors. However, validation of these antibodies for immunohistochemistry in particular is necessary in the first instance. In this study we have investigated the usefulness of several antibodies generated to specific phosphorylated sites within ERalpha for immunohistochemistry of formalin-fixed, paraffin-embedded human breast cancer biopsy samples. As well, these data demonstrate for the first time, the detection of multiple phosphorylated ERalpha forms in breast cancer (P-S104/106-ERalpha, P-S118-ERalpha, P-S167-ERalpha, P-S282-ERalpha, P-S294-ERalpha, P-T311-ERalpha, and P-S559-ERalpha) suggesting the possibility that profiling of phosphorylated ERalpha isoforms might be useful in selecting subgroups of breast cancer patients that would benefit from endocrine therapy.
journal_name
Breast Cancer Res Treatjournal_title
Breast cancer research and treatmentauthors
Skliris GP,Rowan BG,Al-Dhaheri M,Williams C,Troup S,Begic S,Parisien M,Watson PH,Murphy LCdoi
10.1007/s10549-008-0267-zsubject
Has Abstractpub_date
2009-12-01 00:00:00pages
443-53issue
3eissn
0167-6806issn
1573-7217journal_volume
118pub_type
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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更新日期:2004-08-01 00:00:00
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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更新日期:2012-07-01 00:00:00
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journal_title:Breast cancer research and treatment
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更新日期:2016-05-01 00:00:00
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journal_title:Breast cancer research and treatment
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更新日期:2005-02-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
doi:10.1007/s10549-020-05994-8
更新日期:2020-10-30 00:00:00
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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更新日期:2009-04-01 00:00:00
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journal_title:Breast cancer research and treatment
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更新日期:1996-01-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
doi:10.1007/s10549-016-3890-0
更新日期:2016-07-01 00:00:00
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journal_title:Breast cancer research and treatment
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更新日期:2015-01-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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更新日期:2021-01-18 00:00:00
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journal_title:Breast cancer research and treatment
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更新日期:2007-03-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-08-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章,多中心研究
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