Differential effects of propofol and sevoflurane on ischemia-induced ventricular arrhythmias and phosphorylated connexin 43 protein in rats.

abstract：:Isoflurane has protective properties during experimental global brain ischemia or hypoxia. However, this has not been evaluated in the more common case of focal ischemia, e.g., as caused by middle cerebral artery occlusion (MCAO). The authors therefore compared the effects of isoflurane, thiopental, and N2O/fentanyl a...

journal_title：Anesthesiology

authors： Nehls DG,Todd MM,Spetzler RF,Drummond JC,Thompson RA,Johnson PC

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is only approved for use in humans as an intravenous medication. An oral formulation may broaden the use and benefits of dexmedetomidine to numerous care settings. The authors hypothesized that oral dexmedetomidine (300 mcg to 700 mcg) would result in plasma concentrations consistent with sed...

journal_title：Anesthesiology

authors： Chamadia S,Pedemonte JC,Hobbs LE,Deng H,Nguyen S,Cortinez LI,Akeju O

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is a sedative with modest analgesic efficacy, whereas remifentanil is an opioid analgesic with modest sedative potency. Synergy is often observed when sedative-hypnotics are combined with opioid analgesics in anesthetic practice. A three-phase crossover trial was conducted to study the pharma...

journal_title：Anesthesiology

authors： Weerink MAS,Barends CRM,Muskiet ERR,Reyntjens KMEM,Knotnerus FH,Oostra M,van Bocxlaer JFP,Struys MMRF,Colin PJ

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The authors hypothesized that low tidal volume (VT) would minimize ventilator-induced lung injury regardless of the degree of mechanical power. The authors investigated the impact of power, obtained by different combinations of VT and respiratory rate (RR), on ventilator-induced lung injury in experimental m...

journal_title：Anesthesiology

authors： Santos RS,Maia LA,Oliveira MV,Santos CL,Moraes L,Pinto EF,Samary CDS,Machado JA,Carvalho AC,Fernandes MVS,Martins V,Capelozzi VL,Morales MM,Koch T,Gama de Abreu M,Pelosi P,Silva PL,Rocco PRM

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS:ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were ...

journal_title：Anesthesiology

authors： Palmer CM,Emerson S,Volgoropolous D,Alves D

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Ethical conduct in human research in anesthesia includes approval by an institutional review board (IRB) or ethics committee and informed consent. Evidence of these is sometimes lacking in journal publications. METHODS:The authors reviewed all publications involving human subjects in six leading anesthesia ...

journal_title：Anesthesiology

authors： Myles PS,Tan N

更新日期：2003-11-01 00:00:00

abstract：:Malpractice claims filed against anesthesiologists for care involving obstetric (OB) anesthesia (n = 190) were taken from the American Society of Anesthesiologists' Closed Claims Database and compared to claims not involving OB cases (n = 1351). The most common complications in the OB claims were (percentage of all OB...

journal_title：Anesthesiology

authors： Chadwick HS,Posner K,Caplan RA,Ward RJ,Cheney FW

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Propofol has not been studied directly in animals subject to cerebral ischemia in the conscious state. Strokes are usually induced in animals while they are anesthetized, making it difficult to eliminate anesthetic interactions as a complicating factor. Therefore, to compare the neuroprotective effects of pr...

journal_title：Anesthesiology

authors： Gelb AW,Bayona NA,Wilson JX,Cechetto DF

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Propofol is widely used clinically for the induction and maintenance of anesthesia. Clinical case reports have shown that propofol has an antiatrial tachycardia/fibrillation effect; however, the related ionic mechanisms are not fully understood. The current study investigates the effects of propofol on human...

journal_title：Anesthesiology

authors： Yang L,Liu H,Sun HY,Li GR

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) monitoring with arterial waveform display requires an arterial cannula. We evaluated a new noninvasive device, Vasotrac (Medwave, Arden Hills, MN) that provides BP measurements approximately every 12-15 beats and displays pulse rate and a calibrated arterial waveform for each BP measureme...

journal_title：Anesthesiology

authors： Belani K,Ozaki M,Hynson J,Hartmann T,Reyford H,Martino JM,Poliac M,Miller R

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Combining a hypnotic and an analgesic to produce sedation, analgesia, and surgical immobility required for clinical anesthesia is more common than administration of a volatile anesthetic alone. The aim of this study was to apply response surface methods to characterize the interactions between remifentanil a...

journal_title：Anesthesiology

authors： Manyam SC,Gupta DK,Johnson KB,White JL,Pace NL,Westenskow DR,Egan TD

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Propofol is an intravenous anesthetic agent that may impair host defense system. The aim of this study was to evaluate the effects of propofol on macrophage functions and its possible mechanism. METHODS:Mouse macrophage-like Raw 264.7 cells were exposed to propofol, at 3, 30 (a clinically relevant concentra...

journal_title：Anesthesiology

authors： Chen RM,Wu CH,Chang HC,Wu GJ,Lin YL,Sheu JR,Chen TL

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Isoflurane and sevoflurane have been shown to elicit myocardial postconditioning, but the effect of desflurane remain unknown. The authors studied the mechanisms involved in desflurane-induced myocardial postconditioning. METHODS:Contracting isolated human right atrial trabeculae (34 degrees C, stimulation ...

journal_title：Anesthesiology

authors： Lemoine S,Beauchef G,Zhu L,Renard E,Lepage O,Massetti M,Khayat A,Galera P,Gérard JL,Hanouz JL

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Mask ventilation is an essential element of airway management that has rarely been studied as the primary outcome. The authors sought to determine the incidence and predictors of difficult and impossible mask ventilation. METHODS:A four-point scale to grade difficulty in performing mask ventilation (MV) is ...

journal_title：Anesthesiology

authors： Kheterpal S,Han R,Tremper KK,Shanks A,Tait AR,O'Reilly M,Ludwig TA

更新日期：2006-11-01 00:00:00

abstract：:To determine whether neuronal firing is affected by anesthetics, the behavior of neurons in the mesencephalic reticular formation in response to repetitive somatosensory stimulation at 2/sec was studied during wakefulness and during nitrous oxide, halothane, and thiopental anesthesia in the cat. With clinical doses of...

journal_title：Anesthesiology

authors： Shimoji K,Matsuki M,Shimizu H,Maruyama Y,Aida S

更新日期：1977-10-01 00:00:00

abstract：:The relationship of train-of-four (TOF) ratio to the depression of the first twitch (TD) was investigated in 16 patients given pancuronium in doses insufficient to eliminate the fourth response in the train. In ten patients the block was allowed to spontaneously recover (Group 1) and in six it was reversed with neosti...

journal_title：Anesthesiology

authors： Graham GG,Morris R,Pybus DA,Torda TA,Woodey R

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the a...

journal_title：Anesthesiology

authors： Kamiya Y,Andoh T,Furuya R,Hattori S,Watanabe I,Sasaki T,Ito H,Okumura F

更新日期：1999-06-01 00:00:00

abstract：:A carcinogen bioassay of enflurane was performed in Swiss/ICR mice. Two groups of weanling mice, each of 125 males and 125 females, were exposed to eigher a maximum tolerated dose of enflurane, 3000 ppm (0.3 per cent v/v) or compressed air for 4 hs per day, 5 days per week. After 52 weeks exposure, 25 males and 25 fem...

journal_title：Anesthesiology

authors： Baden JM,Egbert B,Mazze RI

更新日期：1982-01-01 00:00:00

abstract：:Myocardial ischemia results when halothane is administered to animals with severe coronary stenosis. This study was done to separate the effect of halothane, per se, on myocardial ischemia from indirect cardiovascular effects, primarily hypotension, that might cause ischemia by altering the oxygen supply-demand balanc...

journal_title：Anesthesiology

authors： Buffington CW

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Intravenously administered anesthetics directly inhibit airway smooth muscle contraction. Because many anesthetic agents affect membrane ion channel function and sustained contraction of airway smooth muscle requires the influx of Ca2+ through voltage-dependent Ca2+ channels, it was hypothesized that intrave...

journal_title：Anesthesiology

authors： Yamakage M,Hirshman CA,Croxton TL

更新日期：1995-12-01 00:00:00

abstract：:Cognitive performance in postsurgical patients may be impaired by disturbances of normal circadian rhythm analogous to those produced by rapid transmeridian travel ("jet lag"). We therefore tested the hypothesis that isoflurane anesthesia alone produces a phase-delay in the human circadian temperature rhythm. We monit...

journal_title：Anesthesiology

authors： Sessler DI,Lee KA,McGuire J

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Neural glial signaling in the spinal cord may underlie pain and sensitization after peripheral injury. The authors test the role of a glial activator, the chemokine (C-C motif) ligand 2 (CCL2), on mechanical hypersensitivity after plantar incision in a rat model of postoperative pain. METHODS:Twenty-four ho...

journal_title：Anesthesiology

authors： Peters CM,Eisenach JC

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:General anesthetics reduce neuron loss following focal cerebral ischemia in rodents. The relative efficacy of this action among different anesthetics clinically used for neuroprotection is uncertain. In addition, it remains unclear how anesthetics compare to neuroprotection afforded by mild hypothermia. This...

journal_title：Anesthesiology

authors： Popovic R,Liniger R,Bickler PE

更新日期：2000-05-01 00:00:00

abstract：:Benchmarking and comparing group productivity is an essential activity of data-driven management. For clinical anesthesiology, accomplishing this task is a daunting effort if meaningful conclusions are to be made. For anesthesiology groups, productivity must be done at the facility level in order to reduce some of the...

journal_title：Anesthesiology

authors： Abouleish AE,Hudson ME,Whitten CW

更新日期：2019-02-01 00:00:00

abstract：:Total lung capacity, vital capacity, residual volume, and functional residual capacity were determined by body plethysmography and the single-breath oxygen (SBO2) test was performed at 0, 5, and 11 cm H20 continuous positive airway pressure in healthy, awake, seated, spontaneously breathing subjects. Mean values for t...

journal_title：Anesthesiology

authors： Abboud N,Rehder K,Rodarte JR,Hyatt RE

更新日期：1975-02-01 00:00:00

abstract：:Minute ventilation (VE), tidal volume (VT), carbon dioxide elimination (VCO2), and end-tidal (PETCO2) and arterial CO2 tensions (PaCO2) were measured in 39 anesthetized infants and children with body weights ranging from 3.1 to 31 kg. Eighteen children had normal cardiopulmonary function, seven had acyanotic congenita...

journal_title：Anesthesiology

authors： Lindahl SG,Yates AP,Hatch DJ

更新日期：1987-02-01 00:00:00

abstract：:The hemodynamic interactions of verapamil and isoflurane were studied in eight dogs. Left ventricular function was analyzed using a right heart bypass preparation to permit rigid hemodynamic control. Hemodynamic studies were performed at 0.7, 1.05, and 1.40% isoflurane before and during the maintenance of two stable l...

journal_title：Anesthesiology

authors： Kates RA,Kaplan JA,Guyton RA,Dorsey L,Hug CC Jr,Hatcher CR

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:The Pediatric Craniofacial Collaborative Group established the Pediatric Craniofacial Surgery Perioperative Registry to elucidate practices and outcomes in children with craniosynostosis undergoing complex cranial vault reconstruction and inform quality improvement efforts. The aim of this study is to determ...

journal_title：Anesthesiology

authors： Stricker PA,Goobie SM,Cladis FP,Haberkern CM,Meier PM,Reddy SK,Nguyen TT,Cai L,Polansky M,Szmuk P,Fiadjoe J,Soneru C,Falcon R,Petersen T,Kowalczyk-Derderian C,Dalesio N,Budac S,Groenewald N,Rubens D,Thompson D,Wat

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Obesity is an important risk factor for surgical site infections. The incidence of surgical wound infections is directly related to tissue perfusion and oxygenation. Fat tissue mass expands without a concomitant increase in blood flow per cell, which might result in a relative hypoperfusion with decreased ti...

journal_title：Anesthesiology

authors： Kabon B,Nagele A,Reddy D,Eagon C,Fleshman JW,Sessler DI,Kurz A

更新日期：2004-02-01 00:00:00

abstract：:Controversy persists about the cardiac toxicity of bupivacaine if accidentally administered intravenously during regional anesthesia. Using awake, unanesthetized sheep, we evaluated the cardiac effects of low and high equivalent doses of lidocaine and bupivacaine given intravenously over 10 s. All animals convulsed wi...

journal_title：Anesthesiology

authors： Kotelko DM,Shnider SM,Dailey PA,Brizgys RV,Levinson G,Shapiro WA,Koike M,Rosen MA

更新日期：1984-01-01 00:00:00