Abstract：
:In the cornea, the epithelium and the underlying stroma are separated by the basement membrane and Bowman's layer. The disruption of these anatomical barriers during wound healing represents a key step which initiates tissue remodeling through the modification of the epithelial-stromal interactions (ESI). Diffusible cytokines are generally viewed as central modulators in the bidirectional communication between these epithelial and stromal compartments and their implication in all stages of the wound healing process has been an active area of research for many years. Our studies which aimed to explore mechanisms of matrix degradation in pathological corneal wound healing have shown that EMMPRIN, a glycoprotein expressed on corneal epithelial cell surface, can induce matrix metalloproteinase (MMP) production and myofibroblasts differentiation after direct interaction with corneal fibroblasts. EMMPRIN appears therefore as a potential mediator of ESI by direct cell-cell contact which represents a new mechanism for dysregulated MMPs' induction observed in corneal ulcerations. These direct epithelial-stromal interactions (direct-ESI) can occur when delayed epithelial healing prevents regeneration of the basement membrane and allows the two cell types to come into close proximity. We propose that prevention of these interactions through inhibition of EMMPRIN may represent a promising therapeutic strategy in the inhibition of MMP induction in ulceration.
journal_name
Prog Retin Eye Resjournal_title
Progress in retinal and eye researchauthors
Gabison EE,Huet E,Baudouin C,Menashi Sdoi
10.1016/j.preteyeres.2008.11.001subject
Has Abstractpub_date
2009-01-01 00:00:00pages
19-33issue
1eissn
1350-9462issn
1873-1635pii
S1350-9462(08)00075-Xjournal_volume
28pub_type
杂志文章,评审abstract：:Regeneration of visual pigments is essential for sustained visual function. Although the requirement for non-photochemical regeneration of the visual chromophore, 11-cis-retinal, was recognized early on, it was only recently that the trans to cis retinoid isomerase activity required for this process was assigned to a ...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2010.03.002
更新日期：2010-09-01 00:00:00
abstract：:Glaucoma is a common neurodegenerative disease that affects retinal ganglion cells (RGCs). Substantial effort is being expended to determine how RGCs die in glaucoma. As in other neurodegenerative diseases, the majority of effort focuses on characterising apoptotic self-destruct pathways. However, apoptosis is not the...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2005.04.004
更新日期：2005-11-01 00:00:00
abstract：:Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve. For several decades, we have understood that the RGC death process was executed by apoptosis, suggesting that there may be ways to therapeutically intervene in this cell death program and provide a more direct treatment to the...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2017.01.002
更新日期：2017-03-01 00:00:00
abstract：:This review considers the critical role of the conjunctiva in determining the success or failure of glaucoma filtration surgery. Glaucoma filtration surgery can be defined as an attempt to lower intraocular pressure (IOP) by the surgical formation of an artificial drainage pathway from the anterior chamber to the subc...
journal_title：Progress in retinal and eye research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.preteyeres.2009.06.004
更新日期：2009-09-01 00:00:00
abstract：:Successful restoration of vision in human patients with gene therapy affirmed its promise to cure ocular diseases and disorders. The efficacy of gene therapy is contingent upon vector and mode of therapeutic DNA introduction into targeted cells/tissues. The cornea is an ideal tissue for gene therapy due to its ease of...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2011.09.001
更新日期：2012-01-01 00:00:00
abstract：:Uveitis is a major cause of blindness, with the visual loss that occurs being due primarily to retinal tissue damage. The tissue damage is mediated mainly by phagocytic inflammatory cells, such as macrophages, by the release of various proteolytic enzymes, arachidonic acid metabolites, cytokines and free radicals. The...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(99)00003-8
更新日期：2000-01-01 00:00:00
abstract：:The ability of the human lens to accommodate is mediated by the ciliary muscle and zonule; the manifest optical power changes depend on the shape and material properties of the lens. The latter are difficult to measure with accuracy and, given the dynamic aspects of accommodation and the ageing of cells and tissues, t...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2018.11.004
更新日期：2019-07-01 00:00:00
abstract：:Neuroprotection is an emerging challenge in ophthalmology due to the particularly exposed location of retinal neurons and to the steadily increasing rate of intraocular surgical and pharmacological treatments applied to various eye diseases. Within few decades neuroprotection has developed from strongly contested appr...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2014.06.004
更新日期：2014-09-01 00:00:00
abstract：:Uveitis is a group of diseases characterized by intraocular inflammation, of which some are driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada disease, Behçet's disease, uveitis associated with spondyloarthritis, ocular sarcoidosis, sympathetic ophthalmia and birdshot chorioretinopathy. T...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2020.100866
更新日期：2021-01-01 00:00:00
abstract：:The link between morphology and physiology for some of the cell types of the macaque monkey retina is reviewed with emphasis on understanding the neural mechanism for spectral opponency in the light response of ganglion cells. An in vitro preparation of the retina is used in which morphologically identified cell types...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(98)00013-5
更新日期：1999-11-01 00:00:00
abstract：:The brains of all vertebrates are persistently neurogenic. However, this is not true for the neural retinas. Only three extant classes of vertebrates show significant posthatch/postnatal retinal neurogenesis: amphibians, birds and fish. The retinas of these animals contain an annulus of progenitors at the margin, from...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2004.01.001
更新日期：2004-03-01 00:00:00
abstract：:The role of alpha-crystallin as a molecular chaperone may explain how the lens stays transparent for so long. Alpha-crystallin prevents the aggregation of other lens crystallins and proteins that have become unfolded by "trapping" the protein in a high molecular weight complex. It also protects enzyme activities. The ...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(98)00030-5
更新日期：1999-07-01 00:00:00
abstract：:Gene expression provides valuable insight into cell function. As such, vision researchers have frequently employed gene expression studies to better understand retinal physiology and disease. With the advent of single-cell RNA sequencing, expression experiments provide an unparalleled resolution of information. Instea...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2020.100934
更新日期：2020-12-28 00:00:00
abstract：:Bacterial endophthalmitis is a sight threatening infection of the interior structures of the eye. Incidence in the US has increased in recent years, which appears to be related to procedures being performed on an aging population. The advent of outpatient intravitreal therapy for management of age-related macular dege...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2012.03.004
更新日期：2012-07-01 00:00:00
abstract：:The vitreous gel is a transparent extracellular matrix that fills the cavity behind the lens of the eye and is surrounded by and attached to the retina. This gel liquefies during ageing and in 25-30% of the oppulation the residual gel structure eventually collapses away from the posterior retina in a process called po...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(99)00016-6
更新日期：2000-05-01 00:00:00
abstract：:Recombinant adeno-associated virus (AAV) is the leading vector for gene therapy in the retina. As non-pathogenic, non-integrating, replication deficient vector, the recombinant virus efficiently transduces all key retinal cell populations. Successful testing of AAV vectors in clinical trials of inherited retinal disea...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2020.100915
更新日期：2020-10-15 00:00:00
abstract：:Purines (in particular, ATP and adenosine) act as neuro- and gliotransmitters in the sensory retina where they are involved in bidirectional neuron-glia signaling. This review summarizes the present knowledge about the expression and functional importance of P1 (adenosine) and P2 (nucleotide) receptors in Müller glial...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2011.06.001
更新日期：2011-09-01 00:00:00
abstract：:Ocular hypertension in glaucoma develops due to age-related cellular dysfunction in the conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two cell types, trabecular meshwork (TM) and Schlemm's canal (SC) endothelia, interact in the juxtacanalicular tissue (JCT) region of the conve...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2014.08.002
更新日期：2015-01-01 00:00:00
abstract：:Phototransduction in vertebrate photoreceptor cells mediated by rhodopsin is one of the most comprehensively examined G protein-coupled receptor (GPCR) signaling pathways. The signal transduction pathway can be mapped from the initial absorption of light to conformational changes within rhodopsin, through activation o...
journal_title：Progress in retinal and eye research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/s1350-9462(03)00017-x
更新日期：2003-07-01 00:00:00
abstract：:Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes and delivered to the lysosome for elimination. In response to stress, autophagy mediates the degradation of cell components, which are recycled...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2016.08.001
更新日期：2016-11-01 00:00:00
abstract：:Renin-Angiotensin System is classically recognized for its role in the control of systemic blood pressure. However, the retina is recognized to have all the components necessary for angiotensin II formation, suggestive of a role for Angiotensin II in the retina that is independent of the systemic circulation. The most...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章
doi：10.1016/j.preteyeres.2010.03.003
更新日期：2010-07-01 00:00:00
abstract：:The macular pigments (MP) absorb light in the blue-green region of the visible spectrum and comprise two carotenoids, lutein and zeaxanthin. In humans the concentration of MP varies widely across the normal population. There are two (not mutually exclusive) proposed roles for MP: to improve visual function and to act ...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2004.05.004
更新日期：2004-09-01 00:00:00
abstract：:Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a marked impact on the wellbeing and productivity of individuals and has a major economic impact on healthcare providers. The only means of treating cataract is by surgical intervention. A modern cataract operation generates a...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2020.100905
更新日期：2020-09-22 00:00:00
abstract：:Diabetes mellitus (DM) is a major health problem with devastating effects on ocular health in both industrialized and developing countries. The control of hyperglycemia is critical to minimizing the impact of DM on ocular tissues because inadequate glycemic control leads to ocular tissue changes that range from a temp...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2016.04.006
更新日期：2016-09-01 00:00:00
abstract：:Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumul...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2017.06.002
更新日期：2017-11-01 00:00:00
abstract：:Leber congenital amaurosis (LCA) is the most severe retinal dystrophy causing blindness or severe visual impairment before the age of 1 year. Linkage analysis, homozygosity mapping and candidate gene analysis facilitated the identification of 14 genes mutated in patients with LCA and juvenile retinal degeneration, whi...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2008.05.003
更新日期：2008-07-01 00:00:00
abstract：:Autoimmune diseases usually follow a relapsing-remitting or a chronic progressive course. To understand the underlying immunopathogenesis we investigated experimental Lewis rat models displaying both disease types, which were only dependent on the autoantigen peptide used for immunization. Retinal S-Antigen-peptide PD...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2018.02.003
更新日期：2018-07-01 00:00:00
abstract：:The patterns of eye movement that accompany static activities such as reading have been studied since the early 1900s, but it is only since head-mounted eye trackers became available in the 1980s that it has been possible to study active tasks such as walking, driving, playing ball games and ordinary everyday activiti...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2006.01.002
更新日期：2006-05-01 00:00:00
abstract：:Although the tear film has been extensively studied as it exists in the open eye state, until recently very little was known as to what happens to the tear film on eye closure. Recent studies have shown that eye closure results in a profound change in the composition, origins, turnover and physiological functions of t...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(00)00006-9
更新日期：2000-11-01 00:00:00
abstract：:In a typical fish eye, the crystalline lens is the only refractive element. It is spherical in shape and has high refractive power. Most fish species have elaborate color vision and spectral sensitivity may range from the near-infrared to the near-ultraviolet. Longitudinal chromatic aberration exceeds depth of focus a...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2012.12.001
更新日期：2013-05-01 00:00:00
