Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase.

abstract：BACKGROUND AND PURPOSE:mTOR inhibitors are currently used as immunosuppressants in transplanted patients and as promising anti-cancer agents. However, new-onset diabetes is a frequent complication occurring in patients treated with mTOR inhibitors such as rapamycin (Sirolimus). Here, we investigated the mechanisms asso...

journal_title：British journal of pharmacology

authors： Deblon N,Bourgoin L,Veyrat-Durebex C,Peyrou M,Vinciguerra M,Caillon A,Maeder C,Fournier M,Montet X,Rohner-Jeanrenaud F,Foti M

更新日期：2012-04-01 00:00:00

abstract：:1. The inhibitory effect of caffeine on the calcium channel current was investigated in cultured myometrial cells isolated from pregnant rats. 2. Caffeine inhibited the calcium channel current elicited from a holding potential of -70 mV in a concentration-dependent manner. The IC50 was estimated to be 35 mM. 3. The ca...

journal_title：British journal of pharmacology

authors： Martin C,Dacquet C,Mironneau C,Mironneau J

更新日期：1989-10-01 00:00:00

abstract：:1 A simple double-isotope assay for phospholipase A2 activity of perfused organs is described; Guinea-pig lungs perfused through the pulmonary circulation exhibit a low background enzyme activity. This activity is blocked by dexamethasone, betamethasone and hydrocortisone, mepacrine, procaine or chlorpromazine. Aspiri...

journal_title：British journal of pharmacology

authors： Blackwell GJ,Flower RJ,Nijkamp FP,Vane JR

更新日期：1978-01-01 00:00:00

abstract：:1. Diabetes mellitus produces marked abnormalities in motor nerve conduction, but the mechanism is not clear. In the present study we hypothesized that in the streptozotocin (STZ)-induced diabetic rat impaired vasodilator function is associated with reduced endoneural blood flow (EBF) which may contribute to nerve dys...

journal_title：British journal of pharmacology

authors： Terata K,Coppey LJ,Davidson EP,Dunlap JA,Gutterman DD,Yorek MA

更新日期：1999-10-01 00:00:00

abstract：:The study investigated the role of endothelin (ET) and the ET receptor subtypes ET(A) and ET(B) in mediating longitudinal contraction in the mouse proximal and distal colon. Cumulative concentration-response curves to a range of ET agonists (ET-1, ET-2, ET-3, (Ala(1,3,11,13)) ET and IRL 1620) were established by admin...

journal_title：British journal of pharmacology

authors： Khan H,Naylor RJ,Tuladhar BR

更新日期：2006-03-01 00:00:00

abstract：:1. The effects of the nonpeptide angiotensin II receptor (AT) antagonists losartan and PD 123319 on actions of angiotensin II in the rat caudal artery and rat vas deferens preparations were investigated. 2. Angiotensin II (1.0 microM) increased perfusion pressure in isolated segments of the rat caudal artery. This inc...

journal_title：British journal of pharmacology

authors： Cox SL,Ben A,Story DF,Ziogas J

更新日期：1995-03-01 00:00:00

abstract：:1. The purpose of this study was to develop and validate an integrated pharmacokinetic-pharmacodynamic model for the anti-lipolytic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine (SPA). Tissue selectivity of SPA was investigated by quantification of haemodynamic and anti-lipolytic effects in...

journal_title：British journal of pharmacology

authors： van Schaick EA,de Greef HJ,Langemeijer MW,Sheehan MJ,IJzerman AP,Danhof M

更新日期：1997-10-01 00:00:00

abstract：:1. The relaxant effects of Zeneca ZD7114, BRL37344 (putative beta 3-adrenoceptor agonists) and various phenylethylamine-based agonists were studied in isolated ileum of the rat where tone was increased with carbachol (0.5 microM). Agonist-induced relaxation.was measured under equilibrium conditions with alpha-, beta 1...

journal_title：British journal of pharmacology

authors： Growcott JW,Holloway B,Green M,Wilson C

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Excessive production of nitric oxide (NO) by inducible NO synthase (iNOS) is thought to underlie the vascular dysfunction, systemic hypotension and organ failure that characterize endotoxic shock. Plasma levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriu...

journal_title：British journal of pharmacology

authors： Panayiotou CM,Baliga R,Stidwill R,Taylor V,Singer M,Hobbs AJ

更新日期：2010-08-01 00:00:00

abstract：:1. It was postulated that swelling dependent chloride channels are involved in the proton secretion of parietal cells. Since omeprazole, lansoprazole and its acid activated sulphenamide form AG2000 are structurally related to phenol derivatives known to block swelling dependent chloride channels, we set out to test, w...

journal_title：British journal of pharmacology

authors： Schmarda A,Dinkhauser P,Gschwentner M,Ritter M,Fürst J,Scandella E,Wöll E,Laich A,Rossmann H,Seidler U,Lang F,Paulmichl M

更新日期：2000-02-01 00:00:00

abstract：:1 Core and tail skin temperature was measured in rats which had guide cannulae implanted into their brains to allow drug injections directly into the preoptic anterior hypothalamus. 2 Apomorphine and dopamine (10 microgram in 1 microliter) injected into the area of the preoptic anterior hypothalamus caused a fall in c...

journal_title：British journal of pharmacology

authors： Cox B,Lee TF

更新日期：1977-09-01 00:00:00

abstract：:1. The vasodilator effects of arginine, nitric oxide (NO), acetylcholine (ACh) and sodium nitroprusside (NP) in the noradrenaline-preconstricted ('high tone') perfused rat kidney have been examined. 2. L-Arginine (0.6-23 mumol) caused a biphasic change in renal perfusion pressure. D-Arginine (0.6-23 mumol) was without...

journal_title：British journal of pharmacology

authors： Bhardwaj R,Moore PK

更新日期：1989-07-01 00:00:00

abstract：:In electrophysiological measurements the beta-carboline ethyl 6-benzyloxy-beta-carboline-3-carboxylate (ZK 91085) acts as a positive allosteric modulator on rat recombinant alpha1beta2gamma2 GABA(A) receptors and binds with high affinity (IC50-1.5 nM) to the [3H]-flunitrazepam site. Flumazenil was able to partially co...

journal_title：British journal of pharmacology

authors： Thomet U,Baur R,Scholze P,Sieghart W,Sigel E

更新日期：1999-07-01 00:00:00

abstract：:Extracellular nucleotides can activate a common purinoceptor mediating various cell responses. In this study we report that stimulation of rat mesangial cells with ATP and UTP leads to a rapid activation of the protein kinase B/Akt (PKB) pathway. Time-course studies reveal a rapid and transient phosphorylation of both...

journal_title：British journal of pharmacology

authors： Huwiler A,Rölz W,Dorsch S,Ren S,Pfeilschifter J

更新日期：2002-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily, is activated by several compounds, including the thiazolidinediones. In addition to being a therapeutic target for obesity, hypolipidaemia and diabetes, perturbation of PPARgamma signalling is now believed to be...

journal_title：British journal of pharmacology

authors： Seargent JM,Yates EA,Gill JH

更新日期：2004-12-01 00:00:00

abstract：:Irritable bowel syndrome is characterized by visceral hyperalgesia commonly associated with stress and inflammatory processes. We investigated the role of tachykinin NK2 receptors in the ability of trinitrobenzenesulphonic acid (TNBS) and stress to enhance the sensitivity of the rat rectum to distension using a select...

journal_title：British journal of pharmacology

authors： Toulouse M,Coelho AM,Fioramonti J,Lecci A,Maggi C,Buéno L

更新日期：2000-01-01 00:00:00

abstract：:Nociceptive tail flick latencies (TFL) were recorded in response to noxious thermal stimuli applied to lightly anaesthetized rats. The effects of intrathecally administered dopamine receptor agonists alone and combined with dopamine receptor antagonists were examined upon the TFL. Experiments were repeated on animals ...

journal_title：British journal of pharmacology

authors： Barasi S,Ben-Sreti MM,Clatworthy AL,Duggal KN,Gonzalez JP,Robertson J,Rooney KF,Sewell RD

更新日期：1987-01-01 00:00:00

abstract：:Botulinum toxin (Type A) depressed or abolished transmission from postganglionic nerves to smooth muscle of isolated preparations of guinea-pig and mouse vas deferens. The time course of blockade was 2 to 6 times slower than that observed with the same concentration of the same batch of toxin on the rat diaphragm. Spo...

journal_title：British journal of pharmacology

authors： Holman ME,Spitzer NC

更新日期：1973-02-01 00:00:00

abstract：:1 We have investigated the effects of loperamide on intracellular Ca(2+) stores and membrane K(+) channels in insulin-secreting hamster insulinoma (HIT-T15) cells. 2 In cell-attached patch-clamp mode, loperamide (3-250 micro M) activated large single-channel currents. The loperamide-activated currents were tentatively...

journal_title：British journal of pharmacology

authors： He LP,Mears D,Atwater I,Rojas E,Cleemann L

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibition of Na(+)-K(+)-ATPase is known to attenuate endothelium-dependent relaxation in many arteries. The purpose of this study was to evaluate the role of Na(+)-K(+)-ATPase in the regulation of endothelial membrane potential at rest and during stimulation by ACh. EXPERIMENTAL APPROACH:Membra...

journal_title：British journal of pharmacology

authors： Bondarenko A,Sagach V

更新日期：2006-12-01 00:00:00

abstract：:1. The effects of inhibiting endogenous Cu/Zn superoxide dismutase (SOD) with diethyldithiocarbamate (DETCA) were examined on the ability of hydroquinone, hydroxocobalamin and carboxy-PTIO to block nitrergic relaxation in the bovine retractor penis (BRP) muscle. 2. Incubation of strips of BRP with DETCA (3 mM) for 2 h...

journal_title：British journal of pharmacology

authors： Paisley K,Martin W

更新日期：1996-04-01 00:00:00

abstract：:1. This study sets out to examine the effect of rilmenidine administered systemically on basal and reflexly activated renal nerve activity in Wistar and stroke prone spontaneously hypertensive rats (SHRSP). 2. Animals were anaesthetized with chloralose/urethane, stimulating electrodes were placed on the brachial plexi...

journal_title：British journal of pharmacology

authors： Zhang T,Johns EJ

更新日期：1996-11-01 00:00:00

abstract：:1. Intracerebral microdialysis was used to examine the function of the terminal 5-hydroxytryptamine (5-HT) autoreceptor in the anterior hypothalamus of anaesthetized rats at two points in the light phase of the light-dark cycle. 2. Infusion of the 5-HT1A/1B agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole ...

journal_title：British journal of pharmacology

authors： Sayer TJ,Hannon SD,Redfern PH,Martin KF

更新日期：1999-04-01 00:00:00

abstract：:1. DL-1-(2-acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride (M & B 17803A) was given to four healthy volunteers in single oral doses of up to 300 mg. There were no subjective effects and no significant alterations in the heart rate, systolic and diastolic blood pressure in the seated posit...

journal_title：British journal of pharmacology

authors： Cuthbert MF,Owusu-Ankomah K

更新日期：1971-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Much interest is currently being focused on the anti-nociceptive effects mediated by nicotinic acetylcholine (nACh) receptors, including their location and mechanism of action. The purpose of this study was to elucidate these issues using 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine (5IA), a nACh re...

journal_title：British journal of pharmacology

authors： Ueda M,Iida Y,Tominaga A,Yoneyama T,Ogawa M,Magata Y,Nishimura H,Kuge Y,Saji H

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Voltage-operated sodium channels constitute major target sites for local anaesthetic-like action. The clinical use of local anaesthetics is still limited by severe side effects, in particular, arrhythmias and convulsions. These side effects render the search for new local anaesthetics a matter of...

journal_title：British journal of pharmacology

authors： Haeseler G,Karst M,Foadi N,Gudehus S,Roeder A,Hecker H,Dengler R,Leuwer M

更新日期：2008-09-01 00:00:00

abstract：:1. We examined the effects of eprosartan, an AT(1) receptor antagonist, on the progression of left ventricular (LV) dysfunction and remodelling in dogs with heart failure (HF) produced by intracoronary microembolizations (LV ejection fraction, EF 30 to 40%). 2. Dogs were randomized to 3 months of oral therapy with low...

journal_title：British journal of pharmacology

authors： Suzuki G,Mishima T,Tanhehco EJ,Sharov VG,Todor A,Rostogi S,Gupta RC,Chaudhry PA,Anagnostopoulos PV,Nass O,Goldstein S,Sabbah HN

更新日期：2003-01-01 00:00:00

abstract：:Tyrosine sulfation is a post-translational modification of secreted and transmembrane proteins, including many GPCRs such as chemokine receptors. Most chemokine receptors contain several potentially sulfated tyrosine residues in their extracellular N-terminal regions, the initial binding site for chemokine ligands. Su...

journal_title：British journal of pharmacology

authors： Ludeman JP,Stone MJ

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Injury to the alveolar epithelium is a critical feature of acute lung injury (ALI). Using a cytokine model of ALI we demonstrated previously that newly recruited mononuclear phagocytes (MNP) contributed to lung inflammation and injury. We hypothesized that cytokines delivered into the alveolar ai...

journal_title：British journal of pharmacology

authors： Parmley LA,Elkins ND,Fini MA,Liu YE,Repine JE,Wright RM

更新日期：2007-11-01 00:00:00

abstract：:1. The drug HA-966 (1-hydroxy-3-amino-pyrrolidone-2), which chemically resembles the cyclic form of GABA, has been studied for neuro-pharmacological properties and for effects on the catecholamine content of the corpus striatum.2. The acute effects on spontaneous behaviour of rodents included flaccid catalepsy and rev...

journal_title：British journal of pharmacology

authors： Bonta IL,De Vos CJ,Grijsen H,Hillen FC,Noach EL,Sim AW

更新日期：1971-11-01 00:00:00