Abstract:
:A theoretical framework is developed to study the dynamics of protein folding. The key insight is that the search for the native protein conformation is influenced by the rate r at which external parameters, such as temperature, chemical denaturant, or pH, are adjusted to induce folding. A theory based on this insight predicts that 1), proteins with complex energy landscapes can fold reliably to their native state; 2), reliable folding can occur as an equilibrium or out-of-equilibrium process; and 3), reliable folding only occurs when the rate r is below a limiting value, which can be calculated from measurements of the free energy. We test these predictions against numerical simulations of model proteins with a single energy scale.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Lois G,Blawzdziewicz J,O'Hern CSdoi
10.1529/biophysj.108.133132subject
Has Abstractpub_date
2008-09-15 00:00:00pages
2692-701issue
6eissn
0006-3495issn
1542-0086pii
S0006-3495(08)78414-5journal_volume
95pub_type
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