Rules of tumor cell development and their application to biomarkers for ovarian cancer.

Abstract:

PURPOSE/OBJECTIVES:To apply the Hanahan and Weinberg conceptual framework for tumor development to the specific biomarkers observed or expressed in ovarian cancer. DATA SOURCES:Data-based publications, topical reviews, and book chapters. DATA SYNTHESIS:Articles specific to ovarian cancer were reviewed to examine whether the six rules from the Hanahan and Weinberg conceptual framework were applicable to biomarkers of ovarian cancer. This approach allows for the application of a general framework for the development of solid tumors to the development of ovarian cancer. CONCLUSIONS:The six rules for tumor cell development outlined in the Hanahan and Weinberg conceptual framework are applicable to biomarkers expressed or observed in patients with ovarian cancer. IMPLICATIONS FOR NURSING:Oncology nurses can enhance their clinical teaching by integrating this information into their practice. Nurses who conduct research on ovarian cancer can use this framework to guide the selection of biomarker(s) for these studies. Finally, nurse educators can use this framework when teaching students key concepts in the care of patients with cancer.

journal_name

Oncol Nurs Forum

journal_title

Oncology nursing forum

authors

McLemore MR,Miaskowski C,Aouizerat BE,Chen LM,Dodd M

doi

10.1188/08.ONF.403-409

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

403-9

issue

3

eissn

0190-535X

issn

1538-0688

pii

8PW0TMP588173U7T

journal_volume

35

pub_type

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