Abstract：
:Our current understanding of the pathophysiology of atherosclerosis suggests a prominent role for immune responses from its initiation through its complications. Given the increasing prevalence of cardiovascular risk factors worldwide, there is an urgent need to better understand the underlying mechanisms to improve current treatment protocols. A growing body of evidence suggests that endocannabinoid signalling plays a critical role in the pathogenesis of atherogenesis and its clinical manifestations. Blocking CB(1) receptors has been shown to mediate not only weight reduction, but also several cardiometabolic effects in rodents and humans, indicating a potential relevance for the process of atherosclerosis. Activation of CB(2) receptors with Delta(9)-tetrahydrocannabinol (THC) has been shown to inhibit atherosclerotic plaque progression in mice, mainly by inhibiting macrophage recruitment. Endocannabinoids released from endothelial cells, macrophages or platelets, reduce hypertension in rodents, a major risk factor for atherosclerosis. In addition, anandamide inhibits inflammatory gene expression in endothelial cells, and consequently monocyte adhesion. Conversely, endocannabinoids might also mediate pro-atherosclerotic effects by inducing platelet activation. In conclusion, the precise role of the endocannabinoid system during atherosclerosis is not yet understood. Whether increased endocannabinoid signalling is associated with disease progression and increased risk of acute thrombotic events remains to be determined.
journal_name
J Neuroendocrinoljournal_title
Journal of neuroendocrinologyauthors
Mach F,Steffens Sdoi
10.1111/j.1365-2826.2008.01685.xsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
53-7eissn
0953-8194issn
1365-2826pii
JNE1685journal_volume
20 Suppl 1pub_type
杂志文章,评审abstract：:We have recently identified nip-2 as a gene target for 17beta-oestradiol activity in the neuroblastoma SK-ER3 cells expressing the oestrogen receptor (ER) alpha. Here we show 17beta-oestradiol treatment of neuroblastoma and rat embryo neurones in culture blocks the increase in nip-2 mRNA induced by apoptotic stimuli a...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2000.00541.x
更新日期：2000-11-01 00:00:00
abstract：:Responsiveness of white adipose tissue (WAT) and brown adipose tissue (BAT) from hibernating and nonhibernating golden-mantled ground squirrels (Spermophilus lateralis) to the lipolytic action of the sympathetic neurotransmitter, noradrenaline, was tested in vitro at temperatures characteristic of deep torpor (5 degre...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2003.01020.x
更新日期：2003-05-01 00:00:00
abstract：:Prostaglandins (PGs) have been implicated in the regulation of vasopressin (VP) and oxytocin (OT) release in response to various stimuli. To examine the site and mechanism of actions of PGs, we studied effects of PGE2 and PG-receptor agonists on supraoptic nucleus (SON) neurones of rat hypothalamic slice preparations ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1998.00282.x
更新日期：1998-12-01 00:00:00
abstract：:Rapid nonclassical effects of 17β-oestradiol (E2 ) on intracellular signalling have been identified in the basal forebrain, although the extent to which these actions may be different in males and females is unknown. Previous work has shown that E2 rapidly phosphorylates cAMP responsive element binding protein (CREB) ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12830
更新日期：2020-01-01 00:00:00
abstract：:Insulin-like growth factor I (IGF-I) and its receptor are present in human and rat anterior pituitary. However, few data exist on the potential presence of IGF-I or its receptor in the non-mammalian pituitary and the cellular sites of IGF-I production have not been identified in any species. Thus, we investigated the ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2000.00464.x
更新日期：2000-05-01 00:00:00
abstract：:Norepinephrine (NE) activates adrenergic receptors (ARs) in the hypothalamic paraventricular nucleus (PVN) to increase excitatory currents, depolarise neurones and, ultimately, augment neuro-sympathetic and endocrine output. Such cellular events are known to potentiate intracellular calcium ([Ca2+ ]i ); however, the r...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12791
更新日期：2019-10-01 00:00:00
abstract：:It is becoming well established that the gut microbiome has a profound impact on human health and disease. In this review, we explore how steroids can influence the gut microbiota and, in turn, how the gut microbiota can influence hormone levels. Within the context of the gut microbiome-brain axis, we discuss how pert...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12548
更新日期：2018-02-01 00:00:00
abstract：:The primary aim of this study was to define the secretory dynamics of oxytocin and vasopressin in pituitary venous effluent from ambulatory horses during acute endotoxaemia, a stimulus that may release both hormones. Our secondary aim was to investigate the role of oxytocin in regulating adrenocorticotropic hormone (A...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2002.00815.x
更新日期：2002-07-01 00:00:00
abstract：:It is well-known that alpha-melanophore-stimulating hormone (alpha-MSH) release from the amphibian pars intermedia (PI) depends on the light condition of the animal's background, permitting the animal to adapt the colour of its skin to background light intensity. In the present study, we carried out nine experiments o...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2004.01247.x
更新日期：2004-11-01 00:00:00
abstract：:The hypothalamic tuberoinfundibular dopaminergic (TIDA) neurones are critical with respect to regulating prolactin secretion from the anterior pituitary. Under most physiological conditions, they are stimulated by prolactin to release dopamine into the median eminence which subsequently suppresses further prolactin se...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12884
更新日期：2020-11-01 00:00:00
abstract：:To determine if glucose availability modulates the timing of the positive feedback action of oestrogen on gonadotropin secretion, we monitored the estradiol-induced luteinizing hormone (LH) surge in sheep (n = 5/group) made transiently hypoglycemic by insulin. Experiment 1 determined an effective insulin treatment, on...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1998.00264.x
更新日期：1998-10-01 00:00:00
abstract：:The plasma concentration of arginine vasopressin (AVP) is closely regulated by plasma osmolality. In this study, we used intronic in-situ hybridization to investigate the transcriptional activity of the AVP gene in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) after intraperitoneal (i.p.) injection of...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1999.00308.x
更新日期：1999-05-01 00:00:00
abstract：:Motherhood induces a series of adaptations in the physiology of the female, including an increase of maternal brain plasticity and a reduction of cell damage in the hippocampus caused by kainic acid (KA) excitotoxicity. We analysed the role of lactation in glial activation in the hippocampal fields of virgin and lacta...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12028
更新日期：2013-06-01 00:00:00
abstract：:Intravenous infusion of hypertonic saline increased plasma [Na (+) ] and osmolality and induced a short-latency drinking response. These changes were associated with increased glucose utilization in the supraoptic and paraventricular nuclei and neural lobe, and decreases in the medial septum and nucleus ambiguus. The ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1992.tb00162.x
更新日期：1992-04-01 00:00:00
abstract：:Two structurally related neuropeptides, pituitary adenylate cyclase-activating polypeptide (PACAP), colocalized with glutamate in neurones of the retinohypothalamic tract, and vasoactive intestinal peptide (VIP), present in light-responsive cells of the suprachiasmatic nuclei (SCN), appear to play distinct and importa...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2826.2003.01005.x
更新日期：2003-04-01 00:00:00
abstract：:The purpose of this study was to downregulate the transcriptional message of arginine vasopressin (AVP) by antisense treatment. A complete phosphorothioate antisense oligodesoxynucleotide corresponding to the beginning of the coding region of rat AVP mRNA was constructed and injected into the lateral ventricle of rats...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1994.tb00561.x
更新日期：1994-04-01 00:00:00
abstract：:The identification of the neural mechanisms controlling ovulation in mammals has long been a 'holy grail' over recent decades, although the recent discovery of the kisspeptin systems has totally changed our views on this subject. Kisspeptin cells are the major link between gonadal steroids and gonadotrophin-releasing ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2010.02022.x
更新日期：2010-07-01 00:00:00
abstract：:To determine whether the photoperiodic responses of reproductive and prolactin (PRL) rhythms in the ewe requires an intact suprachiasmatic nucleus (SCN) driving the pineal rhythm of melatonin secretion, four groups of ovary-intact ewes over a 6-year period were subjected to bilateral (n = 40) or sham lesions (n = 15) ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1995.tb00779.x
更新日期：1995-06-01 00:00:00
abstract：:Seasonal animals use different strategies to reduce energy expenditure in the face of reduced seasonal food availability. For example, the ground squirrel enters a hibernation state with reduced metabolism, hypothermia and suppressed central nervous system activity, whereas the Djungarian hamster (Phodopus sungorus) e...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2007.01620.x
更新日期：2007-12-01 00:00:00
abstract：:Vaginocervical stimulation (VCS) has a variety of effects on the brain, physiology and behaviour. Previous work demonstrated that a progestin antagonist blocked neuronal response to VCS (i.e. Fos expression) in the absence of progesterone in some neurones, and suggested that some of the effects of VCS on the brain are...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.0007-1331.2001.00743.x
更新日期：2002-02-01 00:00:00
abstract：:The expression of corticotropin releasing factor (CRF) and urocortin in hypothalamic magnocellular neurones increases in response to osmotic challenge. To gain a better understanding of the physiological roles of CRF and urocortin in fluid homeostasis, CRF, urocortin and CRF type 1 receptor (CRFR-1) gene expression wa...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2001.00629.x
更新日期：2001-04-01 00:00:00
abstract：:Identification of kisspeptin (Kiss1) and its G protein-coupled receptor 54 (Kiss1r) as an essential component of the hypothalamic-pituitary-gonadal (HPG) axis controlling gonadotrophin secretion raises the possibility that kisspeptin-Kiss1r signalling may play a critical role in the transduction of stress-induced supp...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2008.01807.x
更新日期：2009-01-01 00:00:00
abstract：:The present study aimed to measure the expression of transient receptor potential (TRP) channels in the magnocellular neurones of the paraventricular (PVN) and supraoptic nucleus (SON) in an animal model of hepatic cirrhosis associated with inappropriate vasopressin (AVP) release. In these studies, we used chronic bil...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2011.02273.x
更新日期：2012-04-01 00:00:00
abstract：:Seasonal rhythms in physiology are widespread among mammals living in temperate zones. These rhythms rely on the external photoperiodic signal being entrained to the seasons, although they persist under constant conditions, revealing their endogenous origin. Internal long-term timing (circannual cycles) can be reveale...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12679
更新日期：2019-01-01 00:00:00
abstract：:Preterm labour and birth can be delayed but are generally unstoppable, threatening the health of the mother-baby duo. This may be a result of peripheral signals prematurely recruiting the oxytocin neurones that co-ordinate the timing of birth and, via specialised activity and secretion patterns, drive uterine contract...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2010.02042.x
更新日期：2010-09-01 00:00:00
abstract：:The isolation and identification of a prolactin-releasing factor (PRF) from the neuro-intermediate lobe of the pituitary gland has been pursued for over a decade. Using high-pressure liquid chromatography with electrochemical detection (HPLC-ECD) and gas chromatography/mass spectrometry (GC/MS) (R)-salsolinol (SAL) (a...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2001.00725.x
更新日期：2001-12-01 00:00:00
abstract：:The present study examined whether a transient thyroid hormone (T(4)) deficit during infancy in male monkeys would compromise the arrest of luteinising hormone (LH) secretion during the infant-juvenile transition, and/or interfere with the pubertal resurgence of LH. Animals were orchidectomized and thyroidectomized (n...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2008.01773.x
更新日期：2008-10-01 00:00:00
abstract：:The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. Although the hypothalamic-pituitary-adrenal (HPA) axis remains the best-characterised system for this relationship, other steroid and peptide hormones are in...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12403
更新日期：2016-07-01 00:00:00
abstract：:N-methyl-D-aspartate (NMDA) receptors and gamma-aminobutyric acid (GABA) receptors are involved in the mechanism of pulsatile gonadotrophin-releasing hormone (GnRH) secretion. The aim of this study was to elucidate the role of those receptors in the acceleration of pulsatile GnRH secretion seen at onset of puberty. Us...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1997.00568.x
更新日期：1997-03-01 00:00:00
abstract：:To determine whether the suprachiasmatic nucleus can drive a circadian release of gonadotropin-releasing hormone (GnRH) in the preoptic area, we measured the release of GnRH, arginine-vasopressin and vasoactive intestinal polypeptide (VIP) in cocultures of the preoptic area and the suprachiasmatic nucleus at 2-h inter...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2000.00481.x
更新日期：2000-06-01 00:00:00
