The role of the endocannabinoid system in atherosclerosis.


:Our current understanding of the pathophysiology of atherosclerosis suggests a prominent role for immune responses from its initiation through its complications. Given the increasing prevalence of cardiovascular risk factors worldwide, there is an urgent need to better understand the underlying mechanisms to improve current treatment protocols. A growing body of evidence suggests that endocannabinoid signalling plays a critical role in the pathogenesis of atherogenesis and its clinical manifestations. Blocking CB(1) receptors has been shown to mediate not only weight reduction, but also several cardiometabolic effects in rodents and humans, indicating a potential relevance for the process of atherosclerosis. Activation of CB(2) receptors with Delta(9)-tetrahydrocannabinol (THC) has been shown to inhibit atherosclerotic plaque progression in mice, mainly by inhibiting macrophage recruitment. Endocannabinoids released from endothelial cells, macrophages or platelets, reduce hypertension in rodents, a major risk factor for atherosclerosis. In addition, anandamide inhibits inflammatory gene expression in endothelial cells, and consequently monocyte adhesion. Conversely, endocannabinoids might also mediate pro-atherosclerotic effects by inducing platelet activation. In conclusion, the precise role of the endocannabinoid system during atherosclerosis is not yet understood. Whether increased endocannabinoid signalling is associated with disease progression and increased risk of acute thrombotic events remains to be determined.


J Neuroendocrinol


Mach F,Steffens S




Has Abstract


2008-05-01 00:00:00










20 Suppl 1


  • Regulation of MT melatonin receptor expression in the foetal rat pituitary.

    abstract::During development, melatonin receptors are transiently expressed in multiple neuroendocrine tissues, suggesting a novel role for melatonin in developmental physiology. The best characterised model of melatonin signalling during development is the pars distalis of the rat pituitary. However, although many studies have...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Johnston JD,Klosen P,Barrett P,Hazlerigg DG

    更新日期:2006-01-01 00:00:00

  • Noradrenergic modulation of gonadotrophin-inhibitory hormone gene expression in the brain of Japanese quail.

    abstract::Gonadotrophin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotrophin synthesis and release in birds and mammals. In Japanese quail, GnIH neurones express the noradrenergic receptor and receive noradrenergic innervation. Treatment with noradrenaline (NA) stimulates GnIH release from dience...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Tobari Y,Kansaku N,Tsutsui K

    更新日期:2017-08-01 00:00:00

  • Jacques Benoit lecture: the neuroendocrine view of the angiotensin and apelin systems.

    abstract::The hyperactivity of the brain renin-angiotensin system (RAS) has been implicated in the development and maintenance of hypertension in several types of experimental and genetic hypertension animal models. Among the main bioactive peptides of the brain RAS, angiotensin (Ang) II and Ang III display the same affinity fo...

    journal_title:Journal of neuroendocrinology



    authors: Llorens-Cortes C,Kordon C

    更新日期:2008-03-01 00:00:00

  • Intraneuronal convergence of tactile and hormonal stimuli associated with female reproduction in rats.

    abstract::Stimulation of the vagina and cervix, by mating or manual probing, elicits many behavioral and endocrine changes associated with female reproduction in rats. We and others have identified neurons in the medial preoptic area, medial division of the bed nucleus of the stria terminalis, posterodorsal portion of the media...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Tetel MJ,Celentano DC,Blaustein JD

    更新日期:1994-04-01 00:00:00

  • Carbetocin is a Functional Selective Gq Agonist That Does Not Promote Oxytocin Receptor Recycling After Inducing β-Arrestin-Independent Internalisation.

    abstract::Carbetocin, a long-acting oxytocin analogue, has been reported to elicit interesting and peculiar behavioural effects. The present study investigated the molecular pharmacology of carbetocin, aiming to better understand the molecular basis of its action in the brain. Using bioluminescence resonance energy transfer bio...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Passoni I,Leonzino M,Gigliucci V,Chini B,Busnelli M

    更新日期:2016-04-01 00:00:00

  • NDP-MSH reduces oxidative damage induced by palmitic acid in primary astrocytes.

    abstract::Recent findings relate obesity to inflammation in key hypothalamic areas for body weight control. Hypothalamic inflammation has also been related to oxidative stress. Palmitic acid (PA) is the most abundant free fatty acid found in food, and in vitro studies indicate that it triggers a pro-inflammatory response in the...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Ramírez D,Saba J,Turati J,Carniglia L,Imsen M,Mohn C,Scimonelli T,Durand D,Caruso C,Lasaga M

    更新日期:2019-02-01 00:00:00

  • Immunocytochemical Localization of Glucagon-Related Peptides in the Cerebral Ganglion of the Protochordate Ascidian, Styela plicata.

    abstract::Abstract The central nervous system of the protochordate ascidian Styela plicata has been investigated by means of immunocytochemical techniques in order to localize peptides of the glucagon/secretin family. In particular, glucagon- and peptide histidine isoleucine-containing neurons were localized in the cortex of th...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Pestarino M

    更新日期:1990-10-01 00:00:00

  • Maternal deprivation in rats is associated with corticotrophin-releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood.

    abstract::Exposure to stress during early development causes long-lasting alterations in behaviour and hypothalamic pituitary adrenal (HPA) axis activity, including increased expression of corticotrophin-releasing hormone (CRH). To determine whether early-life stress causes epigenetic changes in the CRH promoter leading to incr...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Chen J,Evans AN,Liu Y,Honda M,Saavedra JM,Aguilera G

    更新日期:2012-07-01 00:00:00

  • Disruption of reproductive rhythms and patterns of melatonin and prolactin secretion following bilateral lesions of the suprachiasmatic nuclei in the ewe.

    abstract::To determine whether the photoperiodic responses of reproductive and prolactin (PRL) rhythms in the ewe requires an intact suprachiasmatic nucleus (SCN) driving the pineal rhythm of melatonin secretion, four groups of ovary-intact ewes over a 6-year period were subjected to bilateral (n = 40) or sham lesions (n = 15) ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Scott CJ,Jansen HT,Kao CC,Kuehl DE,Jackson GL

    更新日期:1995-06-01 00:00:00

  • Emotion and mood adaptations in the peripartum female:complementary contributions of GABA and oxytocin.

    abstract::Peripartum hormones and sensory cues from young modify the maternal brain in ways that can render females either at risk for, or resilient to, elevated anxiety and depression. The neurochemical systems underlying these aspects of maternal emotional and mood states include the inhibitory neurotransmitter GABA and the n...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Lonstein JS,Maguire J,Meinlschmidt G,Neumann ID

    更新日期:2014-10-01 00:00:00

  • Oestrogens and Progestagens: Synthesis and Action in the Brain.

    abstract::When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de novo in neural tissues, they are more specifically referred to as neurosteroids. These neurosteroids bind specific receptors to promote essential brain functions. Pregnenolone supports cognition and protects mouse hippocampal cells aga...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Rossetti MF,Cambiasso MJ,Holschbach MA,Cabrera R

    更新日期:2016-07-01 00:00:00

  • Regulation of sex differences in progesterone receptor expression in the medial preoptic nucleus of postnatal rats.

    abstract::The medial preoptic nucleus (MPN) of the rat, an excellent model for understanding the mechanisms involved in sexual differentiation, is highly sensitive to gonadal hormones during both pre- and post-natal life. Progesterone receptor (PR) expression is sexually dimorphic in the prenatal MPN. Males have significantly h...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Quadros PS,Goldstein AY,De Vries GJ,Wagner CK

    更新日期:2002-10-01 00:00:00

  • Effects of chronic bromocriptine treatment on tyrosine hydroxylase (TH) mRNA expression, TH activity and median eminence dopamine concentrations in ageing rats.

    abstract::The purpose of this study was to investigate the age-related changes in the responsiveness of tuberoinfundibular dopamine (TIDA) neurones to chronic hypoprolactinemia induced by treatment with bromocriptine, a dopamine receptor agonist. In one experiment, TIDA neuronal activity after acute hypoprolactinemia or exogeno...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: MohanKumar PS,MohanKumar SM,Quadri SK,Voogt JL

    更新日期:2001-03-01 00:00:00

  • Development of luteinizing hormone releasing hormone neurones.

    abstract::This review concentrates on some of the recent discoveries and future questions relevant to the development of the neuroendocrine luteinizing hormone releasing hormone (LHRH) cells. Neuroendocrine LHRH cells originate outside the central nervous system, in the nasal placode, and thereafter migrate into the forebrain d...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Wray S

    更新日期:2001-01-01 00:00:00

  • A genomic analysis of subclinical hypothyroidism in hippocampus and neocortex of the developing rat brain.

    abstract::Hypothyroidism during pregnancy and the early postnatal period has severe neurological consequences for the developing offspring. The impact of milder degrees of perturbation of the thyroid axis as encompassed in conditions of subclinical hypothyroidism and hypothyroxinemia, however, has not been established. The pres...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Royland JE,Parker JS,Gilbert ME

    更新日期:2008-12-01 00:00:00

  • Oestrogen requires the insulin-like growth factor-I receptor for stimulation of prolactin synthesis via mitogen-activated protein kinase.

    abstract::Sex steroids and growth factors interact at the intracellular level in a variety of tissues to control numerous physiological functions. Oestrogen is known to stimulate prolactin synthesis and secretion, but the effect of insulin-like growth factor (IGF)-I is less clear. We used GH3 cells, a somatolactotroph cell line...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Arroba AI,Frago LM,Argente J,Chowen JA

    更新日期:2005-02-01 00:00:00

  • Corticosterone controls interleukin-1 beta expression and sickness behavior in the rat.

    abstract::We studied the effect of corticosterone on interleukin (IL)-1 beta synthesis, body temperature, general activity, food consumption and fluid intake in rats treated with bacterial lipopolysaccharide (LPS). Radiotelemetry was used to assess body temperature and locomotor activity in combination with continuous automated...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Pezeshki G,Pohl T,Schöbitz B

    更新日期:1996-02-01 00:00:00

  • Burst firing in gonadotrophin-releasing hormone neurones does not require ionotrophic GABA or glutamate receptor activation.

    abstract::Burst firing is a feature of many neuroendocrine cell types, including the hypothalamic gonadotrophin-releasing hormone (GnRH) neurones that control fertility. The role of intrinsic and extrinsic influences in generating GnRH neurone burst firing is presently unclear. In the present study, we investigated the role of ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Lee K,Liu X,Herbison AE

    更新日期:2012-12-01 00:00:00

  • Oestradiol rapidly enhances spontaneous glycinergic synaptic inhibition of hypoglossal motoneurones.

    abstract::Whereas oestradiol is well-known to facilitate excitatory glutamatergic synaptic transmission, its effects on fast inhibitory neurotransmission are not as well established. Possible acute modulation of the spontaneous glycinergic synaptic activity by oestradiol was investigated in voltage-clamped hypoglossal motoneuro...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Chesnoy-Marchais D,Meillerais A

    更新日期:2008-02-01 00:00:00

  • A focus on reward in anorexia nervosa through the lens of the activity-based anorexia rodent model.

    abstract::Patients suffering anorexia nervosa (AN) become anhedonic, unable or unwilling to derive normal pleasures and tend to avoid rewarding outcomes, most profoundly in food intake. The activity-based anorexia model recapitulates many of the pathophysiological and behavioural hallmarks of the human condition, including a re...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Foldi CJ,Milton LK,Oldfield BJ

    更新日期:2017-10-01 00:00:00

  • Sleep endocrine effects of megestrol acetate in healthy men.

    abstract::Synthetic and naturally occurring steroids exert a variety of neural effects that include modulation of nocturnal sleep. The present study focuses on the effect of progesterone receptor (PR) activation on the nocturnal sleep electroencephalogram (EEG) in male volunteers. As a PR ligand, the synthetic progesterone mege...

    journal_title:Journal of neuroendocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wiedemann K,Hirschmann M,Knaudt K,Rupprecht R,Seier FE,Holsboer F

    更新日期:1998-09-01 00:00:00

  • Localization and Characterization of Insulin-Like Growth Factor-I Receptors in Rat Brain and Pituitary Gland Using in vitro Autoradiography and Computerized Densitometry* A Distinct Distribution from Insulin Receptors.

    abstract::Abstract In order to identify likely sites of action of insulin-like growth factor-I (IGF-I) in rat brain and pituitary gland, we have used the technique of in vitro autoradiography and computerized densitometry to map, characterize and quantify its receptors in coronal and sagittal sections. A discrete and characteri...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Werther GA,Hogg A,Oldfield BJ,McKinley MJ,Figdor R,Mendelsohn FA

    更新日期:1989-10-01 00:00:00

  • Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats.

    abstract::Galanin-like peptide (GALP) is a known mediator of metabolism and reproduction; however, the role that GALP plays in the onset of puberty is unknown. First, we tested the hypothesis that central GALP administration could rescue puberty in food-restricted weanling rats. GALP treatment in food-restricted rats of both se...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Mohr MA,Leathley E,Fraley GS

    更新日期:2012-11-01 00:00:00

  • Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic-Pituitary-Adrenal Axis.

    abstract::The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. Although the hypothalamic-pituitary-adrenal (HPA) axis remains the best-characterised system for this relationship, other steroid and peptide hormones are in...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Borrow AP,Stranahan AM,Suchecki D,Yunes R

    更新日期:2016-07-01 00:00:00

  • The role of oxytocin release in the paraventricular nucleus in the control of maternal behaviour in the sheep.

    abstract::Oxytocin (OT) release within the brain is thought to play a major role in inducing maternal behaviour in a number of mammalian species but little is known about the sites of release which are important in this respect. We have investigated whether the paraventricular nucleus of the hypothalamus (PVN) is a site of OT a...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Da Costa AP,Guevara-Guzman RG,Ohkura S,Goode JA,Kendrick KM

    更新日期:1996-03-01 00:00:00

  • Introduction of a high-energy diet acutely up-regulates hypothalamic cocaine and amphetamine-regulated transcript, Mc4R and brown adipose tissue uncoupling protein-1 gene expression in male Sprague-Dawley rats.

    abstract::Obesity is an escalating problem in Western societies. Susceptibility to weight gain within an obesogenic environment is variable. It remains unclear how the range of weight gain responses are generated. It is possible that an individual's immediate and/or sustained appetite for apparently palatable foods, or metaboli...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Archer ZA,Rayner DV,Duncan JS,Bell LM,Mercer JG

    更新日期:2005-01-01 00:00:00

  • The inhibition of inducible nitric oxide synthase reverts arthritic-induced decrease in pituitary growth hormone mRNA but not in liver insulin-like growth factor I mRNA expression.

    abstract::Experimental arthritis induced by Freund-adjuvant administration is a model of chronic inflammation and rheumatoid arthritis associated with a decrease in pituitary growth hormone (GH) and hepatic insulin-like growth factor I (IGF-I) gene expression. Excessive nitric oxide (NO) synthesis by inducible NO synthase (iNOS...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Ibáñez de Cáceres I,Priego T,Martín AI,López-Calderón A,Villanúa MA

    更新日期:2003-12-01 00:00:00

  • Duality of glutamatergic and GABAergic control of pulsatile GnRH secretion by rat hypothalamic explants: II. Reduced NR2C- and GABAA-receptor-mediated inhibition at initiation of sexual maturation.

    abstract::N-methyl-D-aspartate (NMDA) receptors and gamma-aminobutyric acid (GABA) receptors are involved in the mechanism of pulsatile gonadotrophin-releasing hormone (GnRH) secretion. The aim of this study was to elucidate the role of those receptors in the acceleration of pulsatile GnRH secretion seen at onset of puberty. Us...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Bourguignon JP,Gérard A,Purnelle G,Czajkowski V,Yamanaka C,Lemaître M,Rigo JM,Moonen G,Franchimont P

    更新日期:1997-03-01 00:00:00

  • Perinatal developmental changes in expression of the neuropeptide genes preoptic regulatory factor-1 and factor-2, neuropeptide Y and GnRH in rat hypothalamus.

    abstract::The preoptic regulatory factor genes, PORF-1 and PORF-2, are expressed in the rat brain in a regional-, age- and gender-dependent fashion. They are also expressed in the testis, where PORF-2 mRNA localizes to dividing germ cells while PORF-1 mRNA is associated with newly differentiated sperm. This suggests that PORF-1...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Nowak FV,Gore AC

    更新日期:1999-12-01 00:00:00

  • Peripheral endocannabinoid system-mediated actions of rimonabant on growth hormone secretion are ghrelin-dependent.

    abstract::The somatotroph axis is a crucial pathway regulating metabolism. Despite the fact that the endocannabinoid system has been also revealed as a potent modulator of energy homeostasis, little information is available concerning a putative interaction between these two systems. The aim of the present study was to determin...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Al-Massadi O,Gabellieri E,Trujillo ML,Señaris R,Pagotto U,Pasquali R,Casanueva FF,Seoane LM

    更新日期:2010-11-01 00:00:00