Abstract：
:To determine whether the suprachiasmatic nucleus can drive a circadian release of gonadotropin-releasing hormone (GnRH) in the preoptic area, we measured the release of GnRH, arginine-vasopressin and vasoactive intestinal polypeptide (VIP) in cocultures of the preoptic area and the suprachiasmatic nucleus at 2-h intervals over a period of 120 h. The release of GnRH in cocultures exhibited a significant circadian rhythm in the presence of oestrogen but not in the absence of oestrogen. The period of the GnRH circadian rhythm was the same as that of the arginine-vasopressin circadian rhythm, and different from the VIP circadian rhythm in each coculture. Furthermore, the peak phase of the GnRH rhythm occurred at the time same as that of the arginine-vasopressin rhythm in each coculture. However, the peak phase of the GnRH rhythm was not always the same as that of the VIP rhythm. Administration of arginine-vasopressin significantly increased GnRH release in single preoptic area cultures in the presence of oestrogen, but VIP did not. The result suggests that, in cocultures of the suprachiasmatic nucleus and the preoptic area, arginine-vasopressin neurones drive the circadian release of GnRH in the presence of oestrogen. We suggest that arginine-vasopressin neurones in the suprachiasmatic nucleus mediate the clock information to GnRH neurones in vivo as well.
journal_name
J Neuroendocrinoljournal_title
Journal of neuroendocrinologyauthors
Funabashi T,Shinohara K,Mitsushima D,Kimura Fdoi
10.1046/j.1365-2826.2000.00481.xsubject
Has Abstractpub_date
2000-06-01 00:00:00pages
521-8issue
6eissn
0953-8194issn
1365-2826pii
jne481journal_volume
12pub_type
杂志文章abstract：:The aromatization of testosterone into oestrogens plays a key role in the control of many behavioural and physiological aspects of reproduction. In the quail preoptic area (POA), aromatase activity and the number of aromatase-immunoreactive (ARO-ir) cells are sexually differentiated (males > females). This sex differe...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2000.00532.x
更新日期：2000-09-01 00:00:00
abstract：:Steroid hormones regulate the neuroendocrine and behavioral functions of the brain by using a number of diverse cellular mechanisms. Many steroids exert rapid electrophysiological effects on neurons, involving specific interactions with membrane components, such as neurotransmitter receptors. Previous studies suggest ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1994.tb00592.x
更新日期：1994-06-01 00:00:00
abstract：:Since the glucocorticoid receptor (GR) and/or mineralocorticoid receptor (MR) in the hippocampus have been implicated in cortisol feedback of the hypothalamus-pituitary-adrenal (HPA) axis, abnormalities in those receptors might underlie the hyperactivity of the HPA axis described in patients with major depression. Ani...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1999.00405.x
更新日期：1999-11-01 00:00:00
abstract：:Abstract The effect of intraperitoneally administered gamma-hydroxybutyrate on the hypothalamo-hypophysial-adrenocortical axis was studied. A significant increase in plasma corticosterone was induced by the administration of gamma-hydroxybutyrate (100 mg/kg). The lack of antagonism of this action of gamma-hydroxybutyr...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1990.tb00439.x
更新日期：1990-08-01 00:00:00
abstract：:Thyroid hormones play critical roles in brain maturation and cognitive functions. The present study investigated the role of thyroid hormone in emotional learning and memory using trace and delay contextual and cued fear conditioning tasks, respectively. Rats were administered triiodothyronine (T3) into the dorsal hip...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2006.01480.x
更新日期：2006-11-01 00:00:00
abstract：:Individual variation in the expression of maternal behaviour can affect offspring development and survival. Ewes showing a poorer quality of maternal behaviour (low levels of licking and grooming, infrequent low-pitched bleating, inconsistent udder acceptance) at parturition and throughout lactation (large ewe-lamb di...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2008.01657.x
更新日期：2008-04-01 00:00:00
abstract：:When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de novo in neural tissues, they are more specifically referred to as neurosteroids. These neurosteroids bind specific receptors to promote essential brain functions. Pregnenolone supports cognition and protects mouse hippocampal cells aga...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12402
更新日期：2016-07-01 00:00:00
abstract：:In addition to its established lactational roles, prolactin acts on multiple target tissues and its circulating levels are responsive to a range of physiological stimuli. The present study used immunohistochemistry to demonstrate that systemic administration of prolactin activates target cells in the arcuate nucleus a...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12733
更新日期：2019-06-01 00:00:00
abstract：:Novel approaches to the characterization of coding carried by spike trains are discussed. Measuring firing frequency alone may only partially reflect spike patterning, and can only quantify changes of the most obvious kind. We have devised a method that combines probabilistic and information approaches to quantify the...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.0953-8194.2004.01166.x
更新日期：2004-04-01 00:00:00
abstract：:Since its discovery, leptin (a 167-amino acid product of the OB gene) has quickly moved to the forefront as an important hormone for regulation of energy balance. It closes a feedback loop from adipose tissue to hypothalamic neuropeptide-containing neural circuitry involved in regulation of food intake and neuroendocr...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2826.2001.00707.x
更新日期：2001-10-01 00:00:00
abstract：:Acute stress causes biphasic changes in corticotropin releasing hormone (CRH) receptor mRNA expression with an early decrease followed by an increase. However, in the absence of glucocorticoids in adrenalectomized rats, stress results in prolonged CRH receptor (CRH-R) mRNA loss, suggesting that interactions between gl...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1998.00212.x
更新日期：1998-05-01 00:00:00
abstract：:In some species, including gerbils, guinea pigs, mice, rams and rats, some apparently normal males fail to mate. These kinds of animals have been named 'noncopulating (NC)'. The cause of this behavioural deficit is unknown. The present study aimed to determine whether NC male rats have alterations in the amount of and...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2005.01401.x
更新日期：2006-03-01 00:00:00
abstract：:The interaction between corticosterone and hippocampal 5-HT1A receptor mRNA expression was investigated in male rats. Two days after adrenalectomy, 5-HT1A receptor mRNA was increased in the granule cell layer of the dentate gyrus. Injection of corticosterone led to a significant dose-dependent and transient suppressio...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1995.tb00804.x
更新日期：1995-08-01 00:00:00
abstract：:The role of Ca2+ from extracellular and intracellular sources in stimulating neurosecretion was investigated in four experiments using neuroendocrine bag cells of the marine mollusk Aplysia. (i) Bag cells were treated with either an extracellular calcium chelator (BAPTA) or Co(2+)-substitution within 30 s after onset ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1998.00235.x
更新日期：1998-07-01 00:00:00
abstract：:The aim of the present work was to investigate the possible connection between melatonin, corticosterone and the nonspecific immune response under both basal and stressed conditions. The concentrations used in the present study were as determined in an earlier work, and corresponded to the minimum and maximum concentr...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2002.00823.x
更新日期：2002-09-01 00:00:00
abstract：:The hypothalamic tuberoinfundibular dopaminergic (TIDA) neurones are critical with respect to regulating prolactin secretion from the anterior pituitary. Under most physiological conditions, they are stimulated by prolactin to release dopamine into the median eminence which subsequently suppresses further prolactin se...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12884
更新日期：2020-11-01 00:00:00
abstract：:The distribution of messenger ribonucleic acid (mRNA) encoding preproneuropeptide Y (prepro-NPY) in the hypothalamus of rats subjected to food deprivation or dehydration has been investigated by quantitative in situ hybridization. Levels of prepro-NPY mRNA in the arcuate nucleus (ARC) were selectively increased by bot...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1991.tb00232.x
更新日期：1991-02-01 00:00:00
abstract：:The somatotroph axis is a crucial pathway regulating metabolism. Despite the fact that the endocannabinoid system has been also revealed as a potent modulator of energy homeostasis, little information is available concerning a putative interaction between these two systems. The aim of the present study was to determin...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2010.02065.x
更新日期：2010-11-01 00:00:00
abstract：:Folate is an important regulator of hippocampal neurogenesis, and folic acid is needed prenatally to reduce the risk of neural tube defects. Both high levels of folic acid and low levels of folate can be harmful to health because low levels of folate have been linked to several diseases while high folic acid supplemen...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12787
更新日期：2019-10-01 00:00:00
abstract：:The identification of the neural mechanisms controlling ovulation in mammals has long been a 'holy grail' over recent decades, although the recent discovery of the kisspeptin systems has totally changed our views on this subject. Kisspeptin cells are the major link between gonadal steroids and gonadotrophin-releasing ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2010.02022.x
更新日期：2010-07-01 00:00:00
abstract：:The aim of the present study was to analyse whether hormonal responses could explain an exercise limitation in Down's syndrome (DS). Fourteen young men with DS (mean age 22.5 +/- 0.7 years) and 15 controls (CONT, mean age 22.5 +/- 0.3 years) participated in the study. During a treadmill submaximal incremental test, bl...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2008.01695.x
更新日期：2008-05-01 00:00:00
abstract：:Anabolic androgenic steroids (AAS) are synthetic derivatives of testosterone originally developed for clinical purposes but are now predominantly taken at suprapharmacological levels as drugs of abuse. To date, almost 100 different AAS compounds that vary in metabolic fate and physiological effects have been designed ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2011.02151.x
更新日期：2012-01-01 00:00:00
abstract：:Abstract Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilator peptides known so far. Almost all clinical studies using or measuring CGRP are conducted during the day, and hence this study was carried out to see any variations of CGRP levels in the circulation during this period. Thre...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1991.tb00281.x
更新日期：1991-06-01 00:00:00
abstract：:The spatial and temporal expression of steroidogenic genes in zebrafish has not been fully characterised. Because zebrafish are increasingly employed in endocrine and stress research, a better characterisation of steroidogenic pathways is required to target specific steps in the biosynthetic pathways. In the present s...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12586
更新日期：2018-04-01 00:00:00
abstract：:Abstract In order to localize neuroendocrine dopamine neurons in the monkey hypothalamus, one female and three male juvenile cynomolgus macaques were each given two or three microinjections (0.2 to 0.3 mul per site) of the retrograde tracer wheat germ agglutinin-apoHorseradish peroxidase-10 nm colloidal gold into the ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1990.tb00847.x
更新日期：1990-04-01 00:00:00
abstract：:Prenatal stress is considered as an early epigenetic factor able to induce long-lasting alterations in brain structures and functions. It is still unclear whether prenatal stress can induce long-lasting modifications in the hypothalamo-pituitary-adrenal axis. To test this possibility the effects of restraint stress in...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1994.tb00591.x
更新日期：1994-06-01 00:00:00
abstract：:The pars tuberalis (PT) of the pituitary is central to the control of seasonal breeding. In mammals, the PT translates the photoperiodic message carried by melatonin into an endocrine thyroid-stimulating hormone output, which controls local thyroid hormone (TH) signalling in tanycytes of the neighbouring hypothalamus....
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12640
更新日期：2018-09-01 00:00:00
abstract：:The hypothalamic-neurohypophyseal system (HNS) mediates neuroendocrine responses to dehydration through the actions of the antidiuretic hormone vasopressin (VP) and the natriuetic peptide oxytocin (OT). VP and OT are synthesised as separate prepropeptide precursors in the cell bodies of magnocellular neurones in the h...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2007.01604.x
更新日期：2007-11-01 00:00:00
abstract：:Steroid hormones act both in the brain and throughout the body to influence behaviour and physiology. Many of these effects of steroid hormones are elicited by transcriptional events mediated by their respective receptors. A variety of cell culture studies reveal that nuclear receptor coactivators are critical for mod...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2009.01827.x
更新日期：2009-03-01 00:00:00
abstract：:The authors have identified two types of hippocampal cDNAs for the rat mineralocorticoid receptor (rMR) which are identical in the protein coding domain but differ in their 5'-untranslated sequences. One of these clones encodes a novel type of rMR cDNA with a high homology to a previously described human MR cDNA isola...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1993.tb00508.x
更新日期：1993-08-01 00:00:00
