Abstract:
OBJECTIVE:Manual medicine treatments (MMTs) rely on biophysical techniques that use manually guided forces in numerous strain directions to treat injuries and somatic dysfunctions. Although clinical outcomes post-MMT are positive, the underlying cellular mechanisms responsible remain elusive. We previously described an in vitro model of strain-induced tissue injury and MMTs. Using this model, the current study sought to determine if strain direction (equibiaxial [EQUI] vs heterobiaxial [HETERO]) differentially regulates human fibroblast function. METHODS:Fibroblasts were strained EQUI at 10% beyond their resting length for 48 hours followed by assessment of cell morphology, proliferation, and cytokine secretion via protein cytokine array and enzyme-linked immunosorbent assay (ELISA). These observations were then compared with those obtained previously for HETERO fibroblasts. RESULTS:No alterations in cell morphology were seen in EQUI fibroblasts despite our report of such changes in HETERO cells. Fibroblasts secretion profiles for 60 cytokines (via cytokine protein array) showed that in EQUI strained cells, fractalkine significantly increased (121%), whereas macrophage-derived chemoattractant/chemokine and pulmonary and activation-regulated chemokine significantly decreased (32% and 10%, respectively) compared with nonstrained cells (P < .05). The EQUI fibroblasts when compared with HETERO fibroblasts exhibited a significant decrease in proliferation (22%), inflammatory interleukin 6 secretion (75%, measured by ELISA), and macrophage-derived chemoattractant/chemokine secretion (177%, measured by ELISA, P < .05). CONCLUSIONS:These divergent observations in HETERO vs EQUI strained fibroblasts may underlie the relative efficacies of MMTs carried out in different tissue strain directions. We are currently modeling MMTs such as myofascial release to further investigate this.
journal_name
J Manipulative Physiol Therjournal_title
Journal of manipulative and physiological therapeuticsauthors
Eagan TS,Meltzer KR,Standley PRdoi
10.1016/j.jmpt.2007.07.013subject
Has Abstractpub_date
2007-10-01 00:00:00pages
584-92issue
8eissn
0161-4754issn
1532-6586pii
S0161-4754(07)00243-6journal_volume
30pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study was to establish consensus on a radiographic definition for cervical instability for routine use in chiropractic patients who sustain trauma to the cervical spine. METHOD:We conducted a modified Delphi study with a panel of chiropractic radiologists. Panelists were asked to rate pot...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2017.10.002
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to research the distribution of stresses and displacements in cervical nuclei pulposi during simulated cervical spine manipulation (CSM). METHODS:A 3-dimensional finite element model of C3/4~C6/7 was established. The detailed mechanical parameters of CSM were analyzed and simu...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2014.05.007
更新日期:2014-10-01 00:00:00
abstract::A review of meditation techniques indicates that the suppression of inner speech by the use of a "mental devise" may be a key factor in generating the relaxation response of this procedure. It is hypothesized that the suppression of inner speech would release the diaphragm, temporomandibular joint muscles, and hyoid m...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this preliminary study was to determine feasibility of a clinical trial to measure the effects of manual therapy on sternocleidomastoid active trigger points (TrPs) in patients with cervicogenic headache (CeH). METHODS:Twenty patients, 7 males and 13 females (mean ± SD age, 39 ± 13 years), wit...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmpt.2013.05.022
更新日期:2013-09-01 00:00:00
abstract::There is a relationship between fluid dynamics in the neural canal and cranial vault. This relationship can be affected by posture, respiration and pathology. In addition, several chiropractic disciplines have advocated that axial skeletal improprieties may also affect fluid dynamics in the canal and vault. This paper...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,评审
doi:
更新日期:1988-12-01 00:00:00
abstract:Objective:The purpose of this study was to measure the acute (1 session) and chronic effects (6 sessions) and the follow-up (2 weeks) of anteroposterior articular mobilization of the talus, grade III of Maitland, on the dorsiflexion range of motion (ROM), pain, and functional capacity of individuals with subacute and c...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2017.02.003
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to perform an interexaminer reliability evaluation of the prone leg length analysis procedure. METHODS:Two chiropractors each examined a series of 45 patients with a history of low back pain. Patients were in the prone position, with the knees in both extended and flexed positio...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2007.07.001
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to investigate the possible prognostic value of disk-related magnetic resonance imaging (MRI) findings in relation to recovery at 14 months in patients with severe sciatica, and whether improvement of disk herniation and/or nerve root compromise is concurrent with recovery. METHOD...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2006.12.004
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyze pain intensity in patients with myofascial pain syndrome (MPS) following a multimodal rehabilitation protocol. METHODS:A prospective study was carried out following the Template for Intervention Description and Replication criteria. Patients were recruited from the re...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2017.06.001
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to identify the external and internal reliability and responsiveness of the validated patient-reported outcome measures (PROMs) of neck pain to a standardized regimen of physiotherapy administered acutely after mild whiplash injury using the clinically significant improvement com...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2019.03.007
更新日期:2019-02-01 00:00:00
abstract::An inter- and intra-examiner reliability study was conducted to determine the reliability of a standardized method of motion palpation. Eight senior students in the Palmer College Public Clinic palpated the thoracolumbar spine of 32 student volunteers. Each volunteer was palpated twice by each examiner to allow inter-...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate differences in muscle activity in participants with and without low back pain during a side-lying lumbar diversified spinal manipulation. METHODS:Surface and indwelling electromyography at eight muscle locations were recorded during lumbar side-lying manipulations in...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2016.02.011
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate outcomes of chronic patients unresponsive to previous spinal manipulative therapy subsequently treated with manipulation under anesthesia (MUA). METHODS:A prospective outcome cohort study was performed on 30 patients who had not improved with previous treatment a...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2014.05.002
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:The purpose of this systematic review was to examine literature on workplace factors associated with neck pain or symptoms in computer users performing clerical functions. METHODS:A systematic search of the Cochrane, Medline, CINAHL, and EMBASE databases was conducted for observational and experimental st...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2018.01.005
更新日期:2018-01-01 00:00:00
abstract::The role and position of chiropractic care in the health care system must be transformed from being alternative and separate to alternative and mainstream. This transformation requires that chiropractic services become integrated in the many health care delivery organizations that collectively constitute the health ca...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,评审
doi:10.1016/s0161-4754(00)90080-0
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to propose questions that may be helpful to educate patients considering treatment approaches to manage low back pain (LBP) and to determine if the information currently presented in informed consent (IC) documents at chiropractic colleges is sufficient to help a patient consider...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jmpt.2012.01.004
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the effects of including 1 session of trigger point dry needling (TrP-DN) into a multimodal physiotherapy treatment on pain and function in postoperative shoulder pain. METHODS:Twenty patients (5 male; 15 female; age, 58 ± 12 years) with postoperative shoulder pain a...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmpt.2014.11.007
更新日期:2015-03-01 00:00:00
abstract::A new method for assessing cervicogenic vertigo is presented. This method can quickly assess the origins of vertigo. Preliminary data on 235 patients found that 112, (47.6%), were positive to the tests. After 18 treatments, 101 of the patients (90.2%) were symptom free. The patients responding best suffered acute uppe...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:To discuss intraspinal synovial cysts caused by degenerative changes involving the posterior articular facets in the lumbar spine and to provide differential considerations for patients with low-back pain. CLINICAL FEATURES:A 70-year-old man with low-back and gluteal pain demonstrating eventual progression o...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Force-displacement properties of spinal tissues assessed by blunt indentation are thought to have clinical relevance; however, numerous variables with respect to spinal indentation have yet to be identified or characterized completely. OBJECTIVE:To identify and quantify, where possible, previously unidentif...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 临床试验,杂志文章
doi:10.1067/mmt.2001.112566
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this preliminary study was to demonstrate the feasibility of a study that measures the short-term effects of a course of manual therapy (MT) and exercise (Ex) in people with moderate chronic obstructive pulmonary disease (COPD). METHODS:Fifteen participants (9 males; mean age, 56.1 years), wit...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmpt.2013.05.028
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to test an educational intervention designed to increase hand and treatment table sanitizing on 3 chiropractic college campuses using a theory-based intervention. The second purpose is to see if an increase in observed hand hygiene would be noted as a result of the intervention. ...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2009.06.007
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To discuss the case of a 45-year-old woman, with a prior diagnosis of neurofibromatosis type 1 (NF-1), complaining of low back and cervical spine pain with bilateral upper extremity paresthesias. CLINICAL FEATURES:The patient had a dull, achy, constant low-back pain of 4 months' duration, with mild headaches...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1067/mmt.2003.7
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to review the recent literature on the association between obesity and low back pain, in an effort to determine whether weight control can be considered an appropriate treatment for low back pain, and whether obesity can be considered a primary etiology of low back pain. DATA SO...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,评审
doi:
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:The main objective of the study was to measure the levels of plasma β-endorphin (PB) and plasma cortisol (PC) under lumbar core stabilization exercise (LCSE), placebo and control conditions in patients with chronic nonspecific low back pain. METHODS:Twenty-four participants with chronic nonspecific low back ...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmpt.2018.01.002
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate whether grade III passive lumbar rotational mobilization on L2-3 can improve hip flexor strength and performance in the single-leg triple-hop test in asymptomatic young adults. METHODS:Twenty-four participants (12 men, 12 women) aged from 19 to 26 years who were p...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmpt.2017.07.003
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To assess the intraexaminer and interexaminer reliability of clinicians trained in flexion-distraction technique to determine the need for chiropractic adjustment of each segment of the lumbar spine. DESIGN:This was an intraexaminer and interexaminer reliability study of commonly used chiropractic assessment...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-4754(99)70083-7
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:Nonspecific back pain is associated with high use of diagnostic imaging in primary care, yet current evidence suggests that routine imaging of the spine is unnecessary. The objective of this study is to describe current practice patterns in spine radiograph utilization among doctors of chiropractic enrolled i...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:10.1016/j.jmpt.2013.04.002
更新日期:2013-03-01 00:00:00
abstract::A very rare case of traumatic avulsion fracture of the fabella in a middle-age lady, presented as intermittent posterolateral localized knee pain accentuated by compression against the lateral femoral condyle and by active and passive knee extension, is illustrated. The accumulated chronic microtrauma of the osteoarth...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:A systematic review was performed to evaluate the existing evidence related to the prevalence, incidence, localization, and pathophysiology of myofascial trigger points (MTrPs) in patients with spinal (back and neck) pain. METHODS:A systematic review following Preferred Reporting Items for Systematic Reviews...
journal_title:Journal of manipulative and physiological therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.jmpt.2015.08.004
更新日期:2015-10-01 00:00:00