Abstract:
PURPOSE OF REVIEW:To summarize the application of advanced MRI sequences such as magnetic resonance spectroscopy, diffusion tensor imaging and functional MRI for the evaluation of patients with altered consciousness. RECENT FINDINGS:Magnetic resonance spectroscopy, volumetry and diffusion tensor imaging have shown promising results in the evaluation of traumatic or anoxo-ischaemic brain lesions and can detect damage of the brainstem, basal ganglia and white matter tracts not visible on conventional sequences. A diffusion tensor imaging study has raised the possibility of detecting ongoing axonal regrowth many years after the initial injury in minimally conscious patients. Functional MRI studies have shown that a high level of brain activities, such as recognizing one's own name or imagining playing tennis, can be preserved in vegetative patients. SUMMARY:The development of quantitative imaging could lead to a more objective evaluation of the extent of destruction or preservation of critical brain areas at the acute phase of brain injury, which could be integrated in multi-parametric decisional strategies for these patients. Functional imaging could help define borders between the various levels of altered consciousness and detect the presence of cryptic residual functions in vegetative or minimally conscious patients. This approach could eventually help determine the neurological outcome and make individual blueprints of the preserved brain activities in severely brain injured patients.
journal_name
Curr Opin Neuroljournal_title
Current opinion in neurologyauthors
Galanaud D,Naccache L,Puybasset Ldoi
10.1097/WCO.0b013e3282f169ecsubject
Has Abstractpub_date
2007-12-01 00:00:00pages
627-31issue
6eissn
1350-7540issn
1473-6551pii
00019052-200712000-00005journal_volume
20pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To summarize the currently known side effects of the approved therapies of multiple sclerosis and to suggest monitoring procedures. RECENT FINDINGS:The progress in the treatment of multiple sclerosis with new very effective therapies is accompanied by a number of side effects. Some of these have alre...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0000000000000824
更新日期:2020-06-01 00:00:00
abstract::New functional imaging techniques, including positron emission tomography, transcranial magnetic stimulation and functional magnetic resonance imaging, promise to allow the noninvasive study of haemodynamic, metabolic and activation parameters during acute migraine attacks in humans. These techniques are currently bei...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-199906000-00003
更新日期:1999-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The aims of this article are to review emerging therapies for multiple sclerosis (MS) and to consider new approaches to assessment and achievement of treatment success in patients with this disease. RECENT FINDINGS:A number of disease-modifying therapies for MS, including oral agents, are in advanced...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2012-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Genetic discovery has been extremely rapid over the last year, with many new discoveries illuminating novel mechanisms and pathways. In particular, the application of whole exome and whole genome sequencing has identified many new genetic causes of the epilepsies. As such methods become increasingly a...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0000000000000180
更新日期:2015-04-01 00:00:00
abstract::The population of pediatric patients with cerebrovascular disease presents a unique set of challenges to the neurosurgeon. The wide scope of pathology, including arteriovenous malformations, cavernous malformations and moyamoya disease, coupled with marked advances in diagnosis and treatment of these conditions over t...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-200204000-00007
更新日期:2002-04-01 00:00:00
abstract::Mild cognitive impairment is not an established diagnosis but a concept for which different criteria have been proposed and modified over time. Mild cognitive impairment refers to the transitional zone between normal ageing and dementia. The mild cognitive impairment stage may be one of the optimum stages at which to ...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:
更新日期:2003-12-01 00:00:00
abstract::Migraine is an episodic headache disorder that occurs with or without aura and is often accompanied by other symptoms. Treatment must address these associated symptoms as well as the headache, and it can involve either acute or preventive therapy alone or a combination of both. Acute therapy treats the individual atta...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:1994-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update on the major advances in inflammatory myopathies. RECENT FINDINGS:Polymyositis is an uncommon disorder that can be misdiagnosed when the old, and never validated, criteria of Bohan and Peter are used. New diagnostic criteria were recently introduced, in which the MHC/CD8 complex ...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Cervical spondylotic myelopathy (CSM) is a potentially debilitating disorder primarily related to spinal cord injury caused by degenerative changes of the spine. As the population continues to age and live longer, it is likely that this disorder will be encountered with increasing frequency. RECENT F...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Patients with asymptomatic carotid stenosis are at increased vascular risk but optimal treatment is controversial. We reviewed the current evidence for medical and surgical intervention in these patients. RECENT FINDINGS:Optimal medical treatment is the most important aspect of management of patients...
journal_title:Current opinion in neurology
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doi:10.1097/WCO.0b013e328012da60
更新日期:2007-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite the extensive research carried out in the past decades, the current pathophysiological notions of neurodegenerative disease as well as effective treatments to reduce their progression are largely unknown. Alterations of the human microbiota, the plethora of different microscopic organisms that...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Campylobacter jejuni is the most frequent agent of antecedent infection in an axonal variant of Guillain-Barré syndrome, acute motor axonal neuropathy, and anti-GM1 or anti-GD1a IgG antibody is also associated with acute motor axonal neuropathy. Molecular mimicry has been found between human GM1 gangl...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/01.wco.0000174604.42272.2d
更新日期:2005-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Neuroimaging in motor neuron disease (MND) has traditionally been seen as an academic tool with limited direct relevance to individualized patient care. This has changed radically in recent years as computational imaging has emerged as a viable clinical tool with true biomarker potential. This transit...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0000000000000569
更新日期:2018-08-01 00:00:00
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0b013e328364c04b
更新日期:2013-10-01 00:00:00
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0000000000000272
更新日期:2016-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Over the past 25 years, many autoantibodies directed against peripheral nerve glycan and protein antigens have been described. Principally through this area of research, significant advances have been achieved in the understanding of the pathophysiology of inflammatory neuropathies. More evidence cons...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0b013e328357a77f
更新日期:2012-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Small vessel diseases of the brain are still clinically underrecognized whereas their burden is increasing steeply. The most frequent is acquired degenerative small vessel disease. Many hereditary or idiopathic small vessel diseases have also been identified, of which cerebral autosomal-dominant arter...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/01.wco.0000162861.26971.03
更新日期:2005-04-01 00:00:00
abstract::A review of the literature on methods of seizure or epilepsy severity assessments resulted in tabulation of the seizure rating scales known as US Department of Veterans Affairs (VA), Chalfont-National Hospital, Liverpool, Hague, and others. Each of the scales reviewed has some advantages, but none of them appears to b...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-200104000-00015
更新日期:2001-04-01 00:00:00
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journal_title:Current opinion in neurology
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更新日期:2019-02-01 00:00:00
abstract::Neural circuits comprised of dopamine-containing and dopamine-receptive neurons are altered functionally after the repeated intermittent administration of cocaine and its withdrawal. The characterization of these neuroadaptive changes at various times after repeated exposure to cocaine is important because they may re...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-199712000-00017
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abstract:PURPOSE OF REVIEW:The diagnosis of amyotrophic lateral sclerosis (ALS) still relies mainly on clinical criteria. In present review we will provide an overview of neurochemical ALS biomarkers, which are in the most advanced position on the way towards inclusion into the clinical work-up. RECENT FINDINGS:The field of AL...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/01.wco.0000313358.53553.c7
更新日期:2008-04-01 00:00:00
abstract::Positron emission tomography, single photon emission computed tomography and magnetic resonance spectroscopy provide distinct, uncorrelated and sensitive indicators of brain tumors which can be used to improve differential diagnosis, biopsy guidance or therapy monitoring. New findings, including conflicting ethyl-cyst...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-199612000-00006
更新日期:1996-12-01 00:00:00
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2001-08-01 00:00:00
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journal_title:Current opinion in neurology
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更新日期:2016-04-01 00:00:00
abstract::In multifocal motor or sensorimotor neuropathy with persistent conduction block, most of the recent research has concerned treatment. Open trials show that intravenous immunoglobulin is effective, providing a rapid and often marked clinical improvement, accompanied by a significant reduction of conduction block in som...
journal_title:Current opinion in neurology
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更新日期:1995-10-01 00:00:00
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journal_title:Current opinion in neurology
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更新日期:2003-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this study was to assess the seizure manifestations and risk of epilepsy in encephalitis associated with antibodies against neuronal cell-surface (autoimmune encephalitis) or myelin-associated antigens, and to review several chronic epileptic disorders, including Rasmussen's encephalitis, f...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
abstract::Neuropharmacology is aiding our understanding of the control of eye movements in at least three ways. First, neurotransmitters have been identified in the pathways that coordinate gaze. Second, the technique of pharmacologic inactivation has provided a powerful method to determine the contributions of populations of n...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-199902000-00004
更新日期:1999-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Trigeminal autonomic cephalgias (TACs) are characterized by frequent, short-lasting headache attacks with ipsilateral facial autonomic features. They include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing. The...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/wco.0b013e32832b4bb3
更新日期:2009-06-01 00:00:00