Abstract:
:This paper examined active pharmaceutical ingredients (APIs) acute ecotoxicological modes of action (MOA). It was concluded that the vast majority of APIs acute MOA was non-specific narcosis as; 85% out of 59 APIs had an excess toxicity ratio <7; 70% of the APIs ecotoxicity was overestimated based on a narcotic model; and the majority of APIs Log EC(50)-Log K (ow )regression slopes (-0.49 to -0.86) were within the range of the universal narcosis slopes. However, hydrophobicity is likely not the proper descriptor for assessment of pharmacodynamic APIs chronic ecotoxicity, to asses this accurately new experimental methods need development.
journal_name
Bull Environ Contam Toxicoljournal_title
Bulletin of environmental contamination and toxicologyauthors
Sanderson H,Thomsen Mdoi
10.1007/s00128-007-9249-9subject
Has Abstractpub_date
2007-09-01 00:00:00pages
331-5issue
3eissn
0007-4861issn
1432-0800journal_volume
79pub_type
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