Abstract：
:Topical therapy for rosacea aims to reduce inflammatory lesions and decrease erythema but can carry side effects such as stinging, pruritus, and burning. Metronidazole and azelaic acid gel 15% are U.S. Food and Drug Administration-approved for the treatment of rosacea. The current study was conducted to assess the cumulative irritation potential of 2 formulations of metronidazole 0.75% gel and 1% gel--and azelaic acid gel 15% over 21 days (N=36). Results of this study demonstrated a significantly greater poten tial for irritation from azelaic acid compared with metronidazole gel 0.75% (P < .0001), which had significantly greater potential for irritation compared with metronidazole gel 1% (P = .0054). Metronidazole gel 1% had a similar profile to white petrolatum.
journal_name
Cutisjournal_title
Cutisauthors
Colón LE,Johnson LA,Gottschalk RWsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
317-21issue
4eissn
0011-4162issn
2326-6929journal_volume
79pub_type
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