Acute adrenal insufficiency after a single dose of etomidate.

Abstract:

:Acute adrenocortical insufficiency is a critical care emergency characterized by hemodynamic instability, lethargy, and cardiovascular collapse. Acute adrenal insufficiency has many etiologies, from rapid withdrawal of exogenous glucocorticoids to adrenocortical destruction to poor adrenal reserve after administration of steroid synthesis inhibitors. Etomidate, a parenteral hypnotic agent, is a steroid synthesis inhibitor. Although the use of continuous etomidate infusion in the intensive care unit fell from favor secondary to reports of adrenal crisis, single-dose etomidate for induction of anesthesia is common for the hemodynamically unstable patient or in patients who may not tolerate wide variance in heart rate or blood pressure. A case is presented of acute adrenocortical insufficiency and crisis after a standard induction dose of etomidate. Acute adrenal insufficiency should be suspected in intensive care unit patients who have undergone general anesthesia with etomidate induction and present with hypotension refractory to standard vasopressor administration.

journal_name

J Intensive Care Med

authors

Lundy JB,Slane ML,Frizzi JD

doi

10.1177/0885066606298140

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

111-7

issue

2

eissn

0885-0666

issn

1525-1489

pii

22/2/111

journal_volume

22

pub_type

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