Abstract:
:The main purpose of this report is to describe nine cases of xeroderma pigmentosum with primary spontaneous corneal scarring in the absence of history of corneal ulcers or infectious keratitis. The authors studied nine patients with xeroderma pigmentosum. Each patient underwent complete ophthalmologic and dermatologic examinations. Three patients underwent excision of squamous cell carcinoma of the conjunctiva. There were five male and four female patients, with a mean age of 14 years and a range of 5 to 21 years. Seven had conjunctival squamous cell carcinoma. All patients had spontaneous diffuse corneal stromal scars without clinical evidence of keratitis and no previous history of corneal ulcer. The corneal sensation was intact. None of the patient had ulceration of the cornea. One patient had dry eye syndrome. The clinical and histopathologic changes of the cornea and conjunctiva in patients with xeroderma pigmentosum appear to be similar to the changes occurring in sun-exposed skin. This suggests that direct exposure of corneal and conjunctival tissue to ultraviolet light in patients with xeroderma pigmentosum is the primary cause of scarring in the cornea and conjunctiva, which leads to loss of vision.
journal_name
Ann Saudi Medjournal_title
Annals of Saudi medicineauthors
Tabbara KF,Tabbara WSdoi
10.5144/0256-4947.1996.296subject
Has Abstractpub_date
1996-05-01 00:00:00pages
296-9issue
3eissn
0256-4947issn
0975-4466pii
16-296journal_volume
16pub_type
杂志文章abstract::Hemorrhoid is a common anal problem in our country that is currently treated by many different methods. Three modalities were assessed in a randomized prospective trial in which 848 patients with a second-degree hemorrhoid were treated by rubber band ligation (470 patients), injection sclerotherapy (280 patients), or ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.73
更新日期:1991-01-01 00:00:00
abstract::Placental steroid sulphatase deficiency (SSD) is an X-linked inborn error of metabolism. Congenital X-linked ichthyosis (XLI) is a genetic disorder of keratinisation caused by steroid sulphatase (STS) deficiency, which results in a scaling skin condition in male infants shortly after birth. It may be associated with f...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.445
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Studies about stroke in Saudi Arabia are limited. This retrospective study aims to determine the clinical characteristics of Saudi patients with heart failure (HF) with and without subsequent stroke, and also to find out whether gender differences exist in the presentation of HF patients who h...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2013.387
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Streptococcus pneumoniae is a major cause of mortality and morbidity in both developing and industrialized countries, especially among young children and in both immunocompromised and immunocompetent individuals. It is implicated in both invasive (e.g. meningitis and septicemia) as well as noni...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.83214
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Primary breast lymphoma is a rare disease. The small number of patients and the paucity of data make large-series studies difficult. We conducted a pooled analysis to evaluate the treatment outcome and prognostic factors in patients with primary breast lymphoma. METHODS:In a search of PUBMED and MEDLINE we ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2005.288
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Celiac disease (CD) is an immune-mediated enteropathy, induced by gluten in genetically susceptible individuals. The objective of this study was to describe the clinical pattern of CD in children from the western region of Saudi Arabia. DESIGN AND SETTING:Retrospective, hospital-based. PATIE...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.75779
更新日期:2011-01-01 00:00:00
abstract::During a five year period, 233 cases of malaria (2.4%) were diagnosed among 9259 children with fever and hepatosplenomegaly seen in Asir Central Hospital, Abha, Saudi Arabia. The majority of these were below four years of age and came from Tihama, a hot, humid valley area in the Asir region. The infection was seasonal...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1994.467
更新日期:1994-11-01 00:00:00
abstract::Five cases of enteric fever due to multi-resistant Salmonella typhi are reported. Four of these patients most probably contracted the disease in India and the fifth in Egypt. All of them were successfully treated either with ceftriaxone or ciprofloxacin. ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.246
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Treatment of glioblastoma (GB), the most common malignant primary brain tumor in adults, can include alkylating chemo-therapeutic agents. Two molecular biomarkers of treatment response are MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation and IDH (isocitrate dehydrogenase) mutations, which p...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2019.410
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Fragile X syndrome is the most common cause of inherited mental retardation. Patients with fragile X syndrome show variable mental disability, typical long and narrow facial appearance with large ears and prominent fontanelle and frequent macro-orchidism. It is generally associated with a fragile site at Xq ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2000.214
更新日期:2000-05-01 00:00:00
abstract::Pena-Shokeir phenotype is a unique pattern of lethal multiple congenital anomalies with variable expression. The history of a family in which two sibs conform to Pena-Shokeir phenotype is detailed and substantiates the criteria for definition of the phenotype. The addition of a peculiar ultrasound presentation in the ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.264
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Even though the 50 g oral glucose challenge test (GCT) is the most commonly used screening modality for gestational diabetes mellitus (GDM), no consensus for the diagnostic approach is available to patients with a markedly elevated GCT result. We aimed to evaluate the diagnostic utility of mar...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2012.391
更新日期:2012-07-01 00:00:00
abstract::The patterns of smoking in Jordan were determined in a sample of 3489 subjects representing various strata of society. The sample included 2103 students and 1386 nonstudents. In the nonstudent population, 58.5% of the male and 27.4% of the female subjects were smokers; overall, 96% smoked manufactures cigarettes. Male...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1991.144
更新日期:1991-03-01 00:00:00
abstract::A prospective study of 109 patients with non-classical symptoms of appendicitis using the standard ultrasound (US) machine and plain abdominal x-rays demonstrated that US was superior to plain x-ray with a sensitivitiy, specificity and overall accuracy of 89%, 96% and 91%, respectively as compared with plain x-ray wit...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1993.41
更新日期:1993-01-01 00:00:00
abstract::A study of accessibility, availability, and acceptability of immunization was carried out by interviewing 1422 parents selected randomly from the catchment areas of 15 health care centers in Riyadh. The parents were included if they had children who were under two years or who had not completed the essential immunizat...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1992.339
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In Saudi Arabia (SA), injuries are the second leading cause of death; however, little is known about their frequencies and outcomes. Trauma registries play a major role in measuring the burden on population health. This study aims to describe the population of the only hospital-based trauma re...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2014.291
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The prevalence of overweight/obesity in children in Saudi Arabia is among the highest in the world. The prevalence of dental caries is also high in Saudi children. Studies on the relationship between caries and obesity in Saudi adolescents are lacking. OBJECTIVES:To study the prevalence of overweight/obesit...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2017.114
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The propensity of Ascaris lumbricoides to wander leads to varied surgical complications in the abdomen. Wandering A lumbricoides may sometimes reach the vermiform appendix and its presence there may remain silent or incite pathology. Our aim was to study ascariadial appendicitis. METHODS:Over a period of 3 ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.4103/0256-4947.59380
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Depression is a common condition in primary care medicine in all population groups. We wanted to validate an Arabic translation Zung Self-Rating Depression Scale for Arabic speakers as it has been validated in a number of other languages. METHODS:The hospital translation service translated the English versi...
journal_title:Annals of Saudi medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.5144/0256-4947.2005.205
更新日期:2005-05-01 00:00:00
abstract::Submucosal diathermy of the inferior turbinate (SMDIT) is a generally safe procedure to control inferior turbinate hypertrophy. We present a case of a cerebrospinal fluid (CSF) leak at the craniocervical junction after SMDIT done in another institution. A 27-year-old man presented 3 weeks after undergoing SMDIT with s...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2018.143
更新日期:2018-03-01 00:00:00
abstract::Schistosomiasis (also known as bilharzia, bilharziasis, bilharziosis or snail fever) is a human disease syndrome caused by infection from one of several species of parasitic trematodes of the genus Schistosoma. The three main species infecting humans are S haematobium, S japonicum, and S mansoni. S japonicum is most c...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章,评审
doi:10.4103/0256-4947.51800
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In 2009, pandemic H1N1 influenza A caused significant morbidity and mortality worldwide; however, available data on disease characteristics and outcome of hospitalized children is limited. DESIGN AND SETTING:A prospective cohort study of children who required hospitalization because of the in...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2012.53
更新日期:2012-01-01 00:00:00
abstract::Thiamine-responsive megaloblastic anemia syndrome is a rare autosomal recessive disorder defined by the occurrence of megaloblastic anemia, diabetes mellitus, and bilateral sensorineural deafness, responding in varying degrees to thiamine treatment. We report a precedence case for the treatment of deafness associated ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2014.78
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Adult females have significantly more leptin than males. We investigated the effect of fetal sex on levels of leptin and other pregnancy hormones (progesterone, estradiol, FSH, LH and beta hCG) in pregnant females during different stages of pregnancy. PATIENTS AND METHODS:Serum leptin levels in pregnant fem...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2005.124
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:In children, steroid-resistant nephritic syndrome due to focal segmental glomerulosclerosis (FSGS) is frequently a progressive condition resulting in end-stage renal disease (ESRD). We report the response of 15 patients with steroid resistant FSGS to treatment with intravenous pulse cyclophosphamide (IVCP) a...
journal_title:Annals of Saudi medicine
pub_type: 临床试验,杂志文章
doi:10.5144/0256-4947.2004.27
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The optimal treatment of ureteric stones, especially the lower ureteric stone, remains controversial. The purpose of this study was to evaluate the role of extracorporeal shock wave lithotripsy (ESWL) in the management of ureteric stones. MATERIALS AND METHODS:A total of 99 patients with ureteric stones at ...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2002.18
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Vaccination during periods of lymphopenia may facilitate immune responses to weak self-antigens and enhance antitumor immunity. The objective of this study was to determine the effectiveness of tumor vaccine immunotherapy combined with immune reconstruction using tumor-bearing host immune cells...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2012.162
更新日期:2012-03-01 00:00:00
abstract::There were no studies on the different stages of diabetic nephropathy in Saudi Arabia, particularly the earliest stages. We have therefore investigated the frequency of occurrence of varying degrees of proteinuria including microalbuminuria in noninsulin-dependent diabetes mellitus (NIDDM) Saudi patients as well as th...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1995.120
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Recent studies reveal that a high percentage (over 50%) of episodes for upper respiratory tract infections (URTIs) are treated with antibiotics, regardless of appropriateness or the necessity for prescription. We identified antibiotic prescriptions in a primary health care centre (PHC) and evaluated their su...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.2005.22
更新日期:2005-01-01 00:00:00
abstract::Myocardial perfusion single photon emission-computed tomography (MPS) has been one of the most important and common non-invasive diagnostic cardiac test. Gated MPS provides simultaneous assessment of myocardial perfusion and function with only one study. With appropriate attention to the MPS techniques, appropriate cl...
journal_title:Annals of Saudi medicine
pub_type: 杂志文章,评审
doi:10.4103/0256-4947.87101
更新日期:2011-11-01 00:00:00