Non-biopsy detection of intestinal metaplasia and dysplasia in Barrett's esophagus: a prospective multicenter study.


BACKGROUND AND STUDY AIMS:There have been no multicenter studies investigating the use of magnification chromoendoscopy (MCE) for the detection of intestinal metaplasia and dysplasia/cancer in Barrett's esophagus. Our aims were to assess the ability of MCE to predict the histological diagnosis (non-biopsy detection), to compare the yield of MCE-targeted versus random biopsies for dysplasia, and to compare procedure times. PATIENTS AND METHODS:In this prospective multicenter study, patients with known or suspected Barrett's esophagus underwent MCE with indigo carmine dye staining. Three mucosal patterns (ridge/villous, circular, and irregular/distorted) were standardized, based on past experience. Mucosal patterns were noted and target biopsies were obtained only if irregular/distorted patterns were identified. Otherwise, random four-quadrant biopsies were obtained. RESULTS:A total of 56 patients (mean age 64 years, mean length of Barrett's esophagus 2.7cm) were prospectively evaluated: 38 patients (67.8 %) had ridge/villous patterns, four patients (7.1 %) had circular patterns, four patients (7.1 %) had irregular/distorted patterns, and ten patients (17.8 %) had a combination of patterns. Histologically, intestinal metaplasia was not shown in eight patients (14.2 %), nondysplastic Barrett's esophagus was diagnosed in 30 patients (53.5 %), low-grade dysplasia was detected in 12 patients (21.4 %), and high-grade dysplasia was detected in six patients (10.7 %). An irregular/distorted pattern either throughout the entire segment of Barrett's esophagus or in combination with a ridge/villous or circular pattern had a sensitivity or 83 %, a specificity of 88 %, a positive predictive value of 45 %, and a negative predictive value of 98 % for high-grade dysplasia. The yield of high-grade dysplasia was similar for the two techniques but the time taken to perform MCE was less than the time taken to perform random biopsies. CONCLUSION:An irregular/distorted pattern is specific for high-grade dysplasia and so it may not be necessary to perform biopsies in patients with ridge/villous or circular mucosal patterns.






Sharma P,Marcon N,Wani S,Bansal A,Mathur S,Sampliner R,Lightdale C




Has Abstract


2006-12-01 00:00:00












  • Endoscopic treatment of nonstricture-related benign biliary diseases using covered self-expandable metal stents.

    abstract:BACKGROUND AND STUDY AIMS:Nonstricture benign biliary diseases (BBDs) such as leaks, perforations, and bleeding, have been traditionally managed by placement of one or more plastic stents. Emerging data support the use of covered, self-expandable, metal stents (CSEMSs). The aim of this study was to assess the outcomes ...


    pub_type: 杂志文章


    authors: Irani S,Baron TH,Law R,Akbar A,Ross AS,Gluck M,Gan I,Kozarek RA

    更新日期:2015-04-01 00:00:00

  • An ergonomic analysis of the fulcrum effect in the acquisition of endoscopic skills.

    abstract:BACKGROUND:The loss of three-dimensional visual depth cues has been thought to be the main hindrance to the acquisition of endoscopic skills. However, the "fulcrum effect" of the abdominal wall on the manipulation of instruments has not to our knowledge been previously investigated. METHODS:Subjects with no experience...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gallagher AG,McClure N,McGuigan J,Ritchie K,Sheehy NP

    更新日期:1998-09-01 00:00:00

  • Drainage of deep pelvic abscesses using therapeutic echo endoscopy.

    abstract:BACKGROUND AND STUDY AIMS:The purpose of this study was to evaluate the clinical efficacy of endosonographically guided transrectal aspiration and drainage by plastic stent of deep pelvic abscesses, using a therapeutic echo endoscope device. PATIENTS AND METHODS:Between September 2000 and June 2001, 12 patients (nine ...


    pub_type: 杂志文章


    authors: Giovannini M,Bories E,Moutardier V,Pesenti C,Guillemin A,Lelong B,Delpéro JR

    更新日期:2003-06-01 00:00:00

  • Value of EUS in early detection of pancreatic ductal adenocarcinomas in patients with intraductal papillary mucinous neoplasms.

    abstract:BACKGROUND AND STUDY AIMS:Pancreatic ductal adenocarcinomas (PDAC) sometimes arise in patients with intraductal papillary mucinous neoplasms (IPMNs). This study examined the incidence of PDACs concomitant to or derived from branch duct IPMNs. The usefulness of endoscopic ultrasonography (EUS) relative to other imaging ...


    pub_type: 杂志文章


    authors: Kamata K,Kitano M,Kudo M,Sakamoto H,Kadosaka K,Miyata T,Imai H,Maekawa K,Chikugo T,Kumano M,Hyodo T,Murakami T,Chiba Y,Takeyama Y

    更新日期:2014-01-01 00:00:00

  • Intraoperative and postoperative biliary endoscopy (choledochoscopy).

    abstract::The majority of choledocholithiasis patients still require surgery. If the stones are removed, the patient is cured. With modern cholangiography, the anatomy and the location of the calculi can be immediately identified at the beginning of the operation. In 6% of cases, anomalies of surgical importance are detected. T...


    pub_type: 杂志文章


    authors: Berci G

    更新日期:1989-12-01 00:00:00

  • Cost-effectiveness of capsule endoscopy in screening for colorectal cancer.

    abstract:BACKGROUND AND STUDY AIMS:Capsule endoscopy (Pillcam Colon) has recently shown acceptable accuracy in detecting colonic lesions when compared with colonoscopy. The aim of this analysis is to provide a model to assess the cost and effectiveness of population-based screening for colorectal cancer (CRC) using capsule endo...


    pub_type: 杂志文章


    authors: Hassan C,Zullo A,Winn S,Morini S

    更新日期:2008-05-01 00:00:00

  • Dilatation of benign esophageal strictures by peroral fiberendoscopic bougienage.

    abstract::A low risk procedure for dilation of esophageal strictures is peroral bougienage under direct endoscopic vision with a flexible fiberscope. First the stricture is inspected using the foreward lens of the fiberscope, and then dilated with conventional bougies according to its nature and size under direct visual control...


    pub_type: 杂志文章


    authors: Huchzermeyer H,Freise J,Becker H

    更新日期:1977-11-01 00:00:00

  • Abnormal blood vessels of the prepyloric antrum in cirrhosis of the liver as a cause of chronic gastrointestinal bleeding.

    abstract::Three elderly females presenting with iron deficiency anaemia and faecal loss of blood were found to have a macronodular cirrhosis of the liver and an unusual red spotty appearence of the prepyloric antral mucosa. One patient underwent antral resection and the surgical specimen revealed abnormalities of the (sub)mucos...


    pub_type: 杂志文章


    authors: van Vliet AC,ten Kate FJ,Dees J,van Blankenstein M

    更新日期:1978-05-01 00:00:00

  • Future developments in total Barrett's eradication: the surgeon's view.

    abstract::Endoscopic therapies for the treatment of complicated Barret's esophagus should be embraced by the surgical community. While esophagectomy remains the standard of care for early esophageal neoplasia in many centers, endoscopic techniques are being increasingly utilizid. As refinements in both endoscopic and surgical a...


    pub_type: 杂志文章,评审


    authors: Watson TJ,Peters JH

    更新日期:2008-12-01 00:00:00

  • Pulse oximetry and supplemental oxygen during gastrointestinal endoscopy: a critical review.

    abstract::A high proportion of the mortality and morbidity associated with endoscopic procedures may be of cardiopulmonary origin. For this reason, the appropriate degree of monitoring and prophylactic measures to be used in the sedated patient undergoing endoscopy has become a topic of discussion during recent years. The devel...


    pub_type: 杂志文章,评审


    authors: Holm C,Rosenberg J

    更新日期:1996-10-01 00:00:00

  • Endoscopic ultrasonography in large gastric folds.

    abstract::Large gastric folds are seen in a great number of benign and malignant conditions. Diagnosis is a clinical challenge because the etiology may be extremely varied and standard biopsies are often inconclusive. The gastric wall is considered thickened at endosonography when it is more than 3.6 mm in width. Different dise...


    pub_type: 杂志文章,评审


    authors: Caletti G,Fusaroli P,Bocus P

    更新日期:1998-08-01 00:00:00

  • Initial experience with laparoscopic ultrasound-guided radiofrequency thermal ablation of hepatic tumours.

    abstract:BACKGROUND AND STUDY AIMS:Radiofrequency (RF) thermal ablation has been applied almost exclusively through the percutaneous approach under radiological/external ultrasound guidance. We have embarked on a programme of laparoscopic ultrasound-guided RF ablation of hepatic tumours in view of the potential advantages of th...


    pub_type: 临床试验,杂志文章


    authors: Cuschieri A,Bracken J,Boni L

    更新日期:1999-05-01 00:00:00

  • Dieulafoy's lesion: management and long-term outcome.

    abstract:BACKGROUND AND STUDY AIMS:Dieulafoy's lesion is usually considered to be a rare cause of gastrointestinal bleeding and little information is available about the long-term follow-up of this condition. We studied the clinical pattern and long-term outcome in patients with Dieulafoy's lesion who were managed in a gastroin...


    pub_type: 杂志文章


    authors: Romãozinho JM,Pontes JM,Lérias C,Ferreira M,Freitas D

    更新日期:2004-05-01 00:00:00

  • Early papillary stenosis following successful endoscopic sphincterotomy for residual common bile duct stone.

    abstract::We report a case of early papillary stenosis following successful endoscopic sphincterotomy for residual common bile duct stone which needed surgical revision. In this rare and unexpected complication the importance of early diagnosis is stressed. ...


    pub_type: 杂志文章


    authors: Richieri JP,Pelisier G

    更新日期:1984-03-01 00:00:00

  • Gastroscopic cytology in intestinal metaplasia.

    abstract::Based on the findings of goblet cells the authors established cytologic criteria for the diagnosis of intestinal metaplasia. With this technique they made the diagnosis of intestinal metaplasia in 79.4% of the cases surgically confirmed, this contrast to endoscopic biopsy with only 35.2%. on the other hand, the cytolo...


    pub_type: 杂志文章


    authors: Perez-Mota A,Casanova A,Hidalgo A

    更新日期:1977-03-01 00:00:00

  • A highly accurate method for monitoring histological recovery in patients with celiac disease on a gluten-free diet using an endoscopic approach that avoids the need for biopsy: a double-center study.

    abstract:BACKGROUND AND STUDY AIM:Endoscopy with duodenal biopsy is often performed in order to assess histological recovery in patients with celiac disease who are on a gluten-free diet. Use of the "immersion" technique during upper endoscopy allows visualization of duodenal villi or detection of total villous atrophy. In this...


    pub_type: 杂志文章,多中心研究


    authors: Cammarota G,Cuoco L,Cesaro P,Santoro L,Cazzato A,Montalto M,La Mura R,Larocca LM,Vecchio FM,Gasbarrini A,Salvagnini M,Gasbarrini G

    更新日期:2007-01-01 00:00:00

  • Efficacy of precutting endoscopic mucosal resection with full or partial circumferential incision using a snare tip for difficult colorectal lesions.

    abstract:BACKGROUND:We analyzed the efficacy of precutting endoscopic mucosal resection (EMR), which is a method of making a full or partial circumferential mucosal incision around a tumor with a snare tip for en bloc resection. METHODS:We reviewed cases from 2011 to 2018 in which precutting EMR (n = 167) and standard EMR (n =...


    pub_type: 杂志文章


    authors: Yoshida N,Inoue K,Dohi O,Yasuda R,Hirose R,Naito Y,Murakami T,Ogiso K,Inada Y,Inagaki Y,Morinaga Y,Kishimoto M,Itoh Y

    更新日期:2019-09-01 00:00:00

  • Postoperative biliocutaneous fistula: successful treatment by insertion of an endoprosthesis.

    abstract::An elderly patient with a postoperative biliocutaneous fistula, the persistence of which was due to an unrecognized fibro-malignant stricture of the distal common bile duct, was treated by the insertion of an endoscopic biliary endoprosthesis. Immediately after the procedure, bile discharge through the fistula ceased ...


    pub_type: 杂志文章


    authors: van Steenbergen W,Haemers A,Pelemans W,Ponette E,Vanwing J,Verbeken E,Fevery J

    更新日期:1987-01-01 00:00:00

  • Surveillance colonoscopy and biopsy in patients with ureterosigmoidostomy.

    abstract::Colonoscopy with biopsy was included in the surveillance of 19 patients with ureterosigmoidostomy, because of the high incidence of colonic carcinoma reported in such cases. The patients were examined 1-6 times, at intervals of 1-2 years, 4-36 years after the urinary diversion. Random biopsies from the distal colon an...


    pub_type: 杂志文章


    authors: Berg NO,Fredlund P,Månsson W,Olsson SA

    更新日期:1987-03-01 00:00:00

  • A randomized controlled trial on use of propofol alone versus propofol with midazolam, ketamine, and pentazocine "sedato-analgesic cocktail" for sedation during ERCP.

    abstract:BACKGROUND AND AIMS:Endoscopic retrograde cholangiopancreatography (ERCP) requires adequate patient sedation in order to carry out the procedure successfully. Propofol sedation is being increasingly used during ERCP. There are limited data to evaluate the efficacy of synergistic agents with propofol for sedation during...


    pub_type: 杂志文章,随机对照试验


    authors: Ong WC,Santosh D,Lakhtakia S,Reddy DN

    更新日期:2007-09-01 00:00:00

  • Self-expanding metallic coil stents for palliation of esophageal carcinoma: two cases of decisive stent dysfunction.

    abstract::Two cases of different dysfunctions of self-expanding nickel-titanium coil stents are described here. In the first case, a metallic coil stent was placed in a 8-cm circular rigid stenosis of the mid-esophagus caused by a squamous-cell carcinoma (T3 N1 M1), and seven weeks later, the stent lumen was completely occluded...


    pub_type: 杂志文章


    authors: Löser C,Fölsch UR

    更新日期:1996-08-01 00:00:00

  • Asbestos-induced pleural diseases--thoracoscopic aspects.

    abstract::The endoscopic morphology of asbestos-induced pleural disease is demonstrated by typical thoracoscopic findings. Among 627 thoracoscopies, lesions induced by exposure to asbestos were found in 9.9% (50 malignant mesotheliomas of the pleura, 10 pleural hyalinoses, 2 asbestos pleurisies). This comparatively high percent...


    pub_type: 杂志文章


    authors: Luther R,Wetzer K,Kühne W,Spormann H,Böttger W

    更新日期:1988-05-01 00:00:00

  • Impact of double-balloon endoscopy on the diagnosis of jejunoileal involvement in primary intestinal follicular lymphomas: a case series.

    abstract::In recent years, primary gastrointestinal follicular lymphoma has been increasingly detected in the duodenum on esophagogastroduodenoscopy (EGD). Primary gastrointestinal follicular lymphomas are frequently distributed to multiple sites in the gastrointestinal tract. Therefore, investigation into the spread of follicu...


    pub_type: 杂志文章


    authors: Higuchi N,Sumida Y,Nakamura K,Itaba S,Yoshinaga S,Mizutani T,Honda K,Taki K,Murao H,Ogino H,Kanayama K,Akiho H,Goto A,Segawa Y,Yao T,Takayanagi R

    更新日期:2009-02-01 00:00:00

  • Columnar-lined oesophagus (Barrett's syndrome) - congenital or acquired?

    abstract::A segment of the distal oesophagus lined with columnar epithelium (endobrachy oesophagus, Barrett's oesophagus), is very frequently seen in association with chronic reflux conditions. Usually, this entity is an asymmetrical columnar-cell metaplasia of varying extent, with an unsharp epithelial junction line cranial, a...


    pub_type: 杂志文章


    authors: Stadelmann O,Elster K,Kühn HA

    更新日期:1981-07-01 00:00:00

  • Stent migration requiring surgical removal: a serious adverse event after bariatric megastent placement.

    abstract:: ...


    pub_type: 杂志文章


    authors: Madruga Neto AC,Brunaldi VO,Okazaki O,Santo Filho MA,Miranda Neto AA,Anapaz VL,de Moura EGH

    更新日期:2018-12-01 00:00:00

  • Effect of large fundal varices on changes in gastric mucosal hemodynamics after endoscopic variceal ligation.

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    pub_type: 杂志文章


    authors: Tayama C,Iwao T,Oho K,Toyonaga A,Tanikawa K

    更新日期:1998-01-01 00:00:00

  • Hexaminolevulinate-induced fluorescence colonoscopy versus white light endoscopy for diagnosis of neoplastic lesions in the colon.

    abstract:BACKGROUND AND STUDY AIMS:To compare the rate of detection of colorectal neoplastic lesions using the selective photosensitizer precursor hexaminolevulinate (HAL) combined with a new fluorescence video endoscope system against that of standard white light endoscopy, and secondarily, to evaluate the safety profile of HA...


    pub_type: 杂志文章


    authors: Mayinger B,Neumann F,Kastner C,Haider T,Schwab D

    更新日期:2010-01-01 00:00:00

  • Endohyperthermia--experimental evaluation of a new therapeutic approach for treatment of biliary carcinoma.

    abstract:BACKGROUND AND STUDY AIMS:To improve the prognosis of patients with unresectable, locally advanced bile duct carcinoma, new treatment strategies need to be evaluated. Hyperthermia has been successfully applied as part of multimodal therapy in esophageal and rectal carcinoma. We performed in-vitro and in-vivo experiment...


    pub_type: 杂志文章


    authors: Weigert N,Eckel F,Born P,Erhardt W,Henke J,Werner M,Classen M,Rösch T

    更新日期:2000-04-01 00:00:00

  • Endoscopy and antiplatelet agents. European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

    abstract::With the increasing use of antiplatelet agents (APA), their management during the periendoscopic period has become a more common and more difficult problem. The increase in use is due to the availability of new drugs and the widespread use of drug-eluting coronary stents. Acute coronary syndromes can occur when APA th...


    pub_type: 杂志文章,实务指引


    authors: Boustière C,Veitch A,Vanbiervliet G,Bulois P,Deprez P,Laquiere A,Laugier R,Lesur G,Mosler P,Nalet B,Napoleon B,Rembacken B,Ajzenberg N,Collet JP,Baron T,Dumonceau JM,European Society of Gastrointestinal Endoscopy.

    更新日期:2011-05-01 00:00:00

  • Improved detection of right colon adenomas with additional retroflexion following two forward-view examinations: a prospective study.

    abstract::Background and study aims Colonoscopy in the right colon is less effective than in the left colon in screening for colorectal cancer. The aim of this study was to prospectively evaluate the diagnostic value of retroflexion in the right colon. Patients and methods A total of 1020 patients undergoing screening or survei...


    pub_type: 临床试验,杂志文章


    authors: Lee HS,Jeon SW,Park HY,Yeo SJ

    更新日期:2017-04-01 00:00:00