Linguistic adaptation and validation of the Spanish version of the Benign Prostatic Hyperplasia-Patient Impact Measure (BPH-PIM).

abstract：OBJECTIVE:To characterise the pharmacokinetics of indinavir during different phases of the menstrual cycle in HIV-infected women. DESIGN:Open-label study. SETTING:The immunodeficiency clinic at Erie County Medical Center, Buffalo, New York. PATIENTS:Ten HIV-infected women were enrolled in the study. Eligibility crit...

journal_title：Clinical drug investigation

authors： Frost CE,Adams J,Shelton M,Ebid AH,Gugino LJ,Hewitt R,Difrancesco R,Ingalls E,Cousins S,Hu J,Morse GD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Urinary tract infection (UTI) is a leading cause of morbidity in the female population, with high levels of prevalence and recurrence within 6 months. OBJECTIVES:Our objective was to estimate annual costs and health resource utilization by women with UTIs, and the impact on quality of life (QoL) due to lowe...

journal_title：Clinical drug investigation

authors： Ciani O,Grassi D,Tarricone R

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Vedolizumab, a humanized monoclonal antibody against the α4β7 integrin, is indicated for treatment of moderately to severely active ulcerative colitis or Crohn's disease. In this placebo-controlled, double-blind, randomized, single ascending-dose study, the pharmacokinetics, pharmacodynamics, ...

journal_title：Clinical drug investigation

authors： Rosario M,Wyant T,Leach T,Sankoh S,Scholz C,Parikh A,Fox I,Feagan BG

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In England, the uptake of direct oral anticoagulants (DOACs) for stroke prevention in atrial fibrillation has been slow and varied across different Clinical Commissioning Groups (CCGs). This study aimed to profile the prescribing of oral anticoagulants for stroke prevention in patients with atr...

journal_title：Clinical drug investigation

authors： Medlinskiene K,Fay M,Petty D

更新日期：2019-04-01 00:00:00

abstract：:Mecapegfilgrastim (HHPG-19K) is a long-acting pegylated recombinant human granulocyte-colony stimulating factor (rhG-CSF) that is administered subcutaneously as prophylaxis once per chemotherapy cycle as a weight-adjusted dose of 100 µg/kg or as a 6 mg fixed dose. It is approved in China to reduce the incidence of inf...

journal_title：Clinical drug investigation

authors： Al-Salama ZT,Keam SJ

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The standard of care for HIV treatment is a three-drug regimen consisting of two nucleoside reverse transcriptase inhibitors (NRTIs) and either a non-nucleoside reverse transcriptase inhibitor, a protease inhibitor (PI) or an integrase strand transfer inhibitor. Darunavir boosted with ritonavi...

journal_title：Clinical drug investigation

authors： Lackey P,Mills A,Carpio F,Hsu R,DeJesus E,Pierone G,Henegar C,Fusco J,Fusco G,Wohlfeiler M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Post-marketing surveillance studies can provide supplemental data on the safety of medications in the general population. OBJECTIVE:This study aimed to evaluate the safety of analgesic regimens including the NSAID lornoxicam in the short-term treatment of postoperative pain in a clinically relevant populati...

journal_title：Clinical drug investigation

authors： Rawal N,Krøner K,Simin-Geertsen M,Hejl C,Likar R

更新日期：2010-01-01 00:00:00

abstract：:A liquid formulation of sodium oxybate (Alcover(®)), the sodium salt of γ-hydroxybutyric acid (GHB), is approved in Italy and Austria for use in alcohol withdrawal syndrome and for the maintenance of abstinence in alcohol dependence. This article reviews the efficacy and tolerability of sodium oxybate in alcohol withd...

journal_title：Clinical drug investigation

authors： Keating GM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To determine the efficacy of L-carnitine in reducing hyperammonaemia and improving neuropsychological performance in patients with hepatic cirrhosis and subclinical hepatic encephalopathy (SHE). DESIGN:Randomised, parallel group, controlled trial. PATIENTS AND METHODS:The study enrolled 31 patients with he...

journal_title：Clinical drug investigation

authors： Cecere A,Ciaramella F,Tancredi L,Romano C,Gattoni A

更新日期：2002-11-01 00:00:00

abstract：:The Editor-in-Chief has retracted this article because two of the three studies [1, 2] included in the meta-analysis (cited as references 11 and 12) have been retracted due to fabrication of the data, which has rendered the results of this meta-analysis invalid. ...

journal_title：Clinical drug investigation

authors： Iwamoto J,Matsumoto H,Takeda T

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Recurrent aphthous ulceration is the most common oral mucosal disease known. It presents as three types: minor (most prevalent), major and herpetiform. However, there are no well established effective and reliable treatments of this condition. Alchemilla vulgaris (Lady's Mantle) has traditional...

journal_title：Clinical drug investigation

authors： Shrivastava R,John GW

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Addressing the needs of migraineurs by actively seeking patient feedback on disease-related disability and treatment satisfaction may lead to improved management and treatment outcomes. Patient feedback can be collected in postmarketing surveillance (PMS) studies. The objective of this PMS study was to evalua...

journal_title：Clinical drug investigation

authors： Diener HC,Evers S

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Warfarin-related nephropathy is an unexplained acute kidney injury, and may occur in patients with supratherapeutic INR, in the absence of overt bleeding. Similar findings have been observed in rats treated with dabigatran etexilate. We conducted a prospective study in dabigatran etexilate-tre...

journal_title：Clinical drug investigation

authors： Molteni M,Crippa M,Orenti A,Polo Friz H,Menghini A,Tramacere P,Marano G,Cimminiello C,Boracchi P

更新日期：2019-04-01 00:00:00

abstract：:Twenty-four patients with vascular disorders, randomly divided into 3 dosage groups of 8 patients, were treated with a single oral dose of sulodexide (50, 100 or 200mg) and placebo. Tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1) activity and antigen, euglobulin lysis time, α2-antiplasmin,...

journal_title：Clinical drug investigation

authors： Messa GL,La Placa G,Puccetti L,Acciavatti A,Provvedi T,Palazzini E,Di Perri T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Several drugs may interact with levothyroxine and reduce its bioavailability. The aim of this study was to analyse the Italian general practice patients with hypothyroidism from 2002-2011, in terms of variation of thyroid-stimulating hormone (TSH) levels, number of levothyroxine prescriptions ...

journal_title：Clinical drug investigation

authors： Trifirò G,Parrino F,Sultana J,Giorgianni F,Ferrajolo C,Bianchini E,Medea G,Benvenga S,Cricelli I,Cricelli C,Lapi F

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:European guidelines do not recommend the use of carbamazepine, levetiracetam, phenobarbital, phenytoin, topiramate and valproic acid in patients taking direct oral anticoagulants (DOACs). Little is known regarding the clinical relevance of the interaction between DOACs and antiepileptic drugs. OBJECTIVES:To...

journal_title：Clinical drug investigation

authors： Giustozzi M,Mazzetti M,Paciaroni M,Agnelli G,Becattini C,Vedovati MC

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Following oral administration of abiraterone acetate, the parent compound abiraterone acetate is rapidly metabolized to abiraterone. To our knowledge, bioanalytical methods to date have not been able to detect the parent compound in human plasma, and bioassay was only performed on the metabolit...

journal_title：Clinical drug investigation

authors： Bouhajib M,Tayab Z

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:As an increasing number of elderly are undergoing orthopaedic procedures, it is important to understand and evaluate postoperative pain management in this population, especially in regard to opioid use. Data in the literature pertaining to the very elderly remains scarce. OBJECTIVES:This study was conducted...

journal_title：Clinical drug investigation

authors： Dagenais-Beaulé V,Tourigny JF,Papillon-Ferland L

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The use of budesonide/formoterol as both maintenance and reliever therapy in asthma is recommended in many countries; however, there are limited data available for the Asian patient population. OBJECTIVE:This study aimed to evaluate the short-term safety and tolerability of a fixed high-dose combination of ...

journal_title：Clinical drug investigation

authors： Saito T,Hasunuma T

更新日期：2012-01-01 00:00:00

abstract：:In an in vivo rat model of myocardial infarction, opioid receptor stimulation has been observed to result in a reduction in infarct size similar to that produced by ischaemic preconditioning. The ability of glibenclamide to abolish this effect suggests an involvement of the myocardial ATP-sensitive potassium (K(ATP)) ...

journal_title：Clinical drug investigation

authors： McCormack KJ,Chapleo CB

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Clinical studies have reported that zonisamide is effective for a wide range of seizure types, including refractory partial-onset seizures. However, there have been no reported studies of the efficacy of zonisamide in the Chinese population to date. The aim of the present study was to evaluate ...

journal_title：Clinical drug investigation

authors： Lu Y,Xiao Z,Yu W,Xiao F,Xiao Z,Hu Y,Chen Y,Wang X

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:To evaluate the efficacy and safety of bronchoalveolar lavage (BAL) with diluted porcine surfactant in mechanically ventilated term infants with severe acute respiratory distress syndrome (ARDS) due to meconium aspiration syndrome (MAS). METHODS:Eight consecutive mechanically ventilated term infants with se...

journal_title：Clinical drug investigation

authors： Lista G,Bianchi S,Castoldi F,Fontana P,Cavigioli F

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Clinicians must choose between an increasing number of medications for the treatment of pulmonary arterial hypertension (PAH) with different routes of administration, adverse effects, costs and efficacies. We constructed a decision analysis to help inform treatment choices in PAH. METHODS:We c...

journal_title：Clinical drug investigation

authors： Garin MC,Clark L,Chumney EC,Simpson KN,Highland KB

更新日期：2009-01-01 00:00:00

abstract：:The superior vena cava (SVC) syndrome occurs when obstruction of this vessel interrupts venous return of blood from the head, upper extremities and thorax to the right atrium. Most cases of SVC syndrome result from neoplasia, especially from lung cancer, but other non-cancer-associated causes may include fibrosis caus...

journal_title：Clinical drug investigation

authors： Salmi R,Gaudenzi P,Di Todaro F,Morandi P,Nielsen I,Manfredini R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Polypharmacy, regarded as an indicator of potentially inappropriate medications (PIMs), may lead to a higher risk of serious health consequences in elderly patients with osteoporosis. Thus, this study aimed to analyze the association between polypharmacy and hip fracture in patients with osteop...

journal_title：Clinical drug investigation

authors： Park HY,Kim S,Sohn HS,Kwon JW

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor under clinical investigation in solid tumours. This study evaluated the influence of P-glycoprotein (P-gp) inhibition (single-dose rifampicin) and simultaneous cytochrome P450 3A4 (CYP3A4)/P-gp induction (multiple-dose rifampicin) ...

journal_title：Clinical drug investigation

authors： Shumaker RC,Aluri J,Fan J,Martinez G,Thompson GA,Ren M

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:The efficacy and tolerability of a new combination inhaler containing both salmeterol 50mg and fluticasone 100mg in a single device was compared with the delivery of the two drugs via two separate inhalers in a multicentre, double-blind, double-dummy study. PATIENTS:244 symptomatic asthma patients (age range...

journal_title：Clinical drug investigation

authors： Bateman ED,Britton M,Carrillo J,Almeida J,Wixon C

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Gemigliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor used in the treatment of type 2 diabetes mellitus. This study evaluated possible pharmacodynamic and pharmacokinetic interactions between gemigliptin and metformin and investigated their tolerability. METHODS:A randomized, open-la...

journal_title：Clinical drug investigation

authors： Shin D,Cho YM,Lee S,Lim KS,Kim JA,Ahn JY,Cho JY,Lee H,Jang IJ,Yu KS

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Among the many consequences of loss of CFTR protein function, a significant reduction of the secretion of bicarbonate (HCO3-) in cystic fibrosis (CF) is a major pathogenic feature. Loss of HCO3- leads to abnormally low pH and impaired mucus clearance in airways and other exocrine organs, which suggests that ...

journal_title：Clinical drug investigation

authors： Gomez CCS,Parazzi PLF,Clinckspoor KJ,Mauch RM,Pessine FBT,Levy CE,Peixoto AO,Ribeiro MÂGO,Ribeiro AF,Conrad D,Quinton PM,Marson FAL,Ribeiro JD

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Tendon rupture can result from fluoroquinolone exposure. The objective of this study was to quantify relative and absolute risk and determine how risk is affected by timing of exposure. METHODS:The UK Health Improvement Network primary care database was used to perform a nested case-control st...

journal_title：Clinical drug investigation

authors： Morales DR,Slattery J,Pacurariu A,Pinheiro L,McGettigan P,Kurz X

更新日期：2019-02-01 00:00:00