Sentinel node identification rate, but not accuracy, is significantly decreased after pre-operative chemotherapy in axillary node-positive breast cancer patients.

abstract：PURPOSE:As the number of survivors continues to increase with improvements in breast cancer treatment, greater emphasis has been placed on the aesthetic outcome following breast surgery. Effort is made to minimize scarring on the breast, yet patients who require a port for treatment inevitably have a scar on the upper ...

journal_title：Breast cancer research and treatment

authors： Voci A,Lee D,Ho E,Crane-Okada R,DiNome M

更新日期：2018-08-01 00:00:00

abstract：:The c.156_157insAlu BRCA2 mutation has so far only been reported in hereditary breast/ovarian cancer (HBOC) families of Portuguese origin. Since this mutation is not detectable using the commonly used screening methodologies and must be specifically sought, we screened for this rearrangement in a total of 5,443 suspec...

journal_title：Breast cancer research and treatment

authors： Peixoto A,Santos C,Pinheiro M,Pinto P,Soares MJ,Rocha P,Gusmão L,Amorim A,van der Hout A,Gerdes AM,Thomassen M,Kruse TA,Cruger D,Sunde L,Bignon YJ,Uhrhammer N,Cornil L,Rouleau E,Lidereau R,Yannoukakos D,Pertesi M

更新日期：2011-06-01 00:00:00

abstract：:We previously identified a polymorphism in the human estrogen receptor (ER) gene, within the coding region for the protein's amino terminal B-domain. In estrogen receptor-positive (ER+) breast tumors, the variant allele was preferentially associated with lower levels of ER, and was clinically correlated with frequent ...

journal_title：Breast cancer research and treatment

authors： Schmutzler RK,Sanchez M,Lehrer S,Chaparro CA,Phillips C,Rabin J,Schachter B

更新日期：1991-10-01 00:00:00

abstract：:The polypeptide hormone prolactin (Prl), acting through its cell surface receptors, promotes growth and differentiation in normal and malignant breast cells. We demonstrate herein that two Prl-responsive cell lines, NOG-8 normal mouse mammary epithelial and T47D human breast cancer cells, respond to Prl by rapid and t...

journal_title：Breast cancer research and treatment

authors： Das R,Vonderhaar BK

更新日期：1996-01-01 00:00:00

abstract：:Seventy-two patients underwent dye-guided or dye- and gamma probe-guided sentinel lymphadenectomy (SLND) followed by complete axillary lymph node dissection (ALND). The results of imprint cytology, frozen sections, and permanent sections of the sentinel lymph node (SLN) were compared to each other and to the histologi...

journal_title：Breast cancer research and treatment

authors： Noguchi M,Bando E,Tsugawa K,Miwa K,Yokoyama K,Nakajima K,Michigishi T,Tonami N,Minato H,Nonomura A

更新日期：1999-09-01 00:00:00

abstract：:Estrogen receptor alpha (ERalpha) is a well-known target for signaling pathways originating from growth factor receptors. Reactive oxygen species (ROS) can induce activation of extracellular response kinase 1/2 (Erk1/2) and protein kinase B (Akt). Both kinases have been implicated in the phosphorylation of serine 118 ...

journal_title：Breast cancer research and treatment

authors： Weitsman GE,Weebadda W,Ung K,Murphy LC

更新日期：2009-11-01 00:00:00

abstract：:Estrogenic steroids, such as estradiol, are known to play a crucial role in the development and growth of hormone-dependent breast cancer. Steroid sulfatase (STS) inhibitors that can prevent the biosynthesis of these steroids via the sulfatase pathway offer therapeutic potential. We show here the in vivo profile, incl...

journal_title：Breast cancer research and treatment

authors： Foster PA,Chander SK,Parsons MF,Newman SP,Woo LW,Potter BV,Reed MJ,Purohit A

更新日期：2008-09-01 00:00:00

abstract：:The uptake and retention of a radiolabeled synthetic progestin ORG 2058 by the mammary glands were examined in the baboon. Four estrogen-primed baboons were injected intravenously with 2.5 micrograms/kg body weight of 3H-ORG 2058. One animal received an additional injection of 2.5 mg/kg body weight of unlabeled proges...

journal_title：Breast cancer research and treatment

authors： Weaker FJ,Sheridan PJ

更新日期：1984-01-01 00:00:00

abstract：:Although younger women with breast cancer have the most to gain from receipt of optimal care, few data are available regarding their receipt of locoregional breast cancer treatments. We identified 317,596 women aged 18-64 who were diagnosed with invasive breast cancer at hospitals reporting to the National Cancer Data...

journal_title：Breast cancer research and treatment

authors： Freedman RA,Virgo KS,Labadie J,He Y,Partridge AH,Keating NL

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To determine if response to endocrine therapy of breast cancer can be predicted by either a metabolic "flare reaction" detected by positron emission tomography (PET) with 2-[(18)F]-fluoro-2-deoxyglucose (FDG), induced by an estradiol challenge, or by estrogen-receptor (ER) status, determined by PET with the est...

journal_title：Breast cancer research and treatment

authors： Dehdashti F,Mortimer JE,Trinkaus K,Naughton MJ,Ellis M,Katzenellenbogen JA,Welch MJ,Siegel BA

更新日期：2009-02-01 00:00:00

abstract：:HER2/neu overexpression leads to poorer prognosis and higher risk of disease reoccurrence in breast cancer patients. The causative factors responsible for increasing HER2/neu expression levels on mammary cells are not known. We investigated whether factors associated with inflammation or metastasis could induce HER2/n...

journal_title：Breast cancer research and treatment

authors： Fatunmbi M,Shelton J,Aronica SM

更新日期：2012-09-01 00:00:00

abstract：:Beta-blockers (BB) drugs have been used for decades worldwide, mainly to treat hypertension. However, in recent epidemiological studies, BBs were suggested to improve cancer prognosis. In the wake of this evidence, we evaluated the possible therapeutic effect of BBs in triple-negative breast cancer (TNBC) patients. We...

journal_title：Breast cancer research and treatment

authors： Botteri E,Munzone E,Rotmensz N,Cipolla C,De Giorgi V,Santillo B,Zanelotti A,Adamoli L,Colleoni M,Viale G,Goldhirsch A,Gandini S

更新日期：2013-08-01 00:00:00

abstract：:We report a series of breast cancer patients with invasive skin and nail infections with Staphylococcus species that we attribute to the addition of pertuzumab to trastuzumab-based therapy. With the suspicion of an increased incidence of cutaneous infection in patients treated with pertuzumab and trastuzumab-based che...

journal_title：Breast cancer research and treatment

authors： Mortimer J,Jung J,Yuan Y,Kruper L,Stewart D,Chung S,Yu KW,Mendelsohn M,D'Apuzzo M,Tegtmeier B,Dadwal S

更新日期：2014-12-01 00:00:00

abstract：:We analyzed the p53 mutational status, mRNA and protein expression in 24 human breast carcinoma cell lines. Following measurement of their DNA content with flow cytometry, we ascertained the copy numbers of the centromere of chromosome 17 (cen17) and p53 with fluorescence in situ hybridization (FISH). A functional yea...

journal_title：Breast cancer research and treatment

authors： Concin N,Zeillinger C,Tong D,Stimpfl M,König M,Printz D,Stonek F,Schneeberger C,Hefler L,Kainz C,Leodolter S,Haas OA,Zeillinger R

更新日期：2003-05-01 00:00:00

abstract：:Findings from epidemiologic studies of oxidative stress biomarkers and breast cancer have been mixed, although no studies have focused on estrogen receptor-negative (ER-) tumors which may be more strongly associated with oxidative stress. We examined prediagnostic plasma fluorescent oxidation products (FlOP), a global...

journal_title：Breast cancer research and treatment

authors： Hirko KA,Fortner RT,Hankinson SE,Wu T,Eliassen AH

更新日期：2016-07-01 00:00:00

abstract：:Clinical evidence regarding the value of MRI for therapy responses assessment in breast cancer is increasing. The objective of this study is to compare the diagnostic capability of diffusion-weighted MR imaging (DW-MRI) and contrast-enhanced MR imaging (CE-MRI) to evaluate and predict pathological response in breast c...

journal_title：Breast cancer research and treatment

authors： Wu LM,Hu JN,Gu HY,Hua J,Chen J,Xu JR

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:To examine the outcomes of endocrine naive patients treated with tamoxifen as initial endocrine therapy for metastatic breast cancer. Data were obtained from the long-term follow-up of two previously published randomized trials. PATIENTS AND METHODS:All patients received tamoxifen 20 mg po in a single daily do...

journal_title：Breast cancer research and treatment

authors： Kuss JT,Muss HB,Hoen H,Case LD

更新日期：1997-02-01 00:00:00

abstract：:Paclitaxel and vinorelbine are among the most active new agents in metastatic breast cancer. Both in vitro and in vivo studies have shown that the combined administration of these two microtubule-targeting agents is feasible and worthwhile. Based on the promising preclinical data, patients with metastatic breast cance...

journal_title：Breast cancer research and treatment

authors： Tortoriello A,Facchini G,Caponigro F,Santangelo M,Benassai G,Persico G,Citarella A,Carola M,Marzano N,Iaffaioli RV

更新日期：1998-01-01 00:00:00

abstract：:Although preoperative magnetic resonance imaging (MRI) can detect mammographically occult contralateral breast cancers (CBCs) among women with ductal carcinoma in situ (DCIS), the impact of MRI on the incidence of subsequent CBC events is unclear. We examined whether MRI use decreases CBC occurrences and detection of ...

journal_title：Breast cancer research and treatment

authors： Wang SY,Long JB,Killelea BK,Evans SB,Roberts KB,Silber A,Gross CP

更新日期：2016-07-01 00:00:00

abstract：:We compared the following parameters in Long-Evans (LE) and Sprague-Dawley (SD) female rats: 1) mammary tumor incidence after DMBA, 2) plasma prolactin (PRL) during the estrous cycle before and after DMBA, 3) plasma PRL in immature females from 0900 hr on day 29 to 0900 hr on day 30, 4) plasma PRL from 1200 to 1700 hr...

journal_title：Breast cancer research and treatment

authors： Lawson DM,Sensui N,Haisenleder DH,Kaufman PN,Gala RR

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:TOP2A gene encodes topoisomerase II alpha, the direct molecular target of anthracyclines. This gene is frequently coamplified with HER2. The aims of this study were to analyse the pattern of TOP2A amplification and protein expression in relation to the molecular subgroups of breast cancers; and to define the...

journal_title：Breast cancer research and treatment

authors： Arriola E,Rodriguez-Pinilla SM,Lambros MB,Jones RL,James M,Savage K,Smith IE,Dowsett M,Reis-Filho JS

更新日期：2007-12-01 00:00:00

abstract：:Women with diabetes have higher breast cancer incidence and mortality. The purpose of this study was to examine the impact of diabetes on stage at breast cancer diagnosis, as a possible reason for their higher mortality. Using population-based health databases from Ontario, Canada, this retrospective cohort study exam...

journal_title：Breast cancer research and treatment

authors： Lipscombe LL,Fischer HD,Austin PC,Fu L,Jaakkimainen RL,Ginsburg O,Rochon PA,Narod S,Paszat L

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:This study examined the influence of knowledge of clinical information on the accuracy of mammography in women referred for investigation of breast symptoms. METHODS:Subjects were sampled from all women consecutively attending a symptomatic breast clinic and aged 25-55 years. This included all 240 women show...

journal_title：Breast cancer research and treatment

authors： Houssami N,Irwig L,Simpson JM,McKessar M,Blome S,Noakes J

更新日期：2004-06-01 00:00:00

abstract：:We investigated the role of glial cell line-derived neurotrophic factor (GDNF) in compensating trastuzumab (TZMB)-induced apoptosis in HER2+ breast cancer (BC) cells using xenograft tumors. We generated BC xenografts in nude mice using samples from three patients selected based on their HER2 status and response to TZM...

journal_title：Breast cancer research and treatment

authors： Gardaneh M,Shojaei S,Kaviani A,Behnam B

更新日期：2017-04-01 00:00:00

abstract：:Fibroblast growth factor receptor 2 (FGFR2) is a member of a receptor tyrosine kinase gene superfamily, involved in cell growth, invasiveness, motility, and angiogenesis, which has attracted considerable attention as a candidate gene for breast cancer (BC) since it was first identified through genome-wide association ...

journal_title：Breast cancer research and treatment

authors： Wang H,Yang Z,Zhang H

更新日期：2013-01-01 00:00:00

abstract：:Current evidence suggests that the majority of DCIS lesions do not progress to invasive carcinoma, and overtreatment of DCIS is a significant problem. We previously reported an 8-gene signature that differentiated microdissected low-grade (LG) DCIS lesions with and without associated stromal invasion, based on differe...

journal_title：Breast cancer research and treatment

authors： Geradts J,Groth J,Wu Y,Jin G

更新日期：2016-06-01 00:00:00

abstract：:A review of the current literature on immunohistologic and histochemical methods for the detection of steroid hormone binding sites in breast cancer, reveals that many, but not all of the criteria for establishing hormone-receptor binding interactions have been met. These include tissue specificity, binding between la...

journal_title：Breast cancer research and treatment

authors： Pertschuk LP,Tobin EH,Carter AC,Eisenberg KB,Leo VC,Gaetjens E,Bloom ND

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To explore the ability of intraoperative specimen radiography (SR) to correctly identify positive margins in patients receiving breast conserving surgery (BCS). To assess whether the reoperation rate can be reduced by using this method. METHODS:This retrospective study included 470 consecutive cases receiving ...

journal_title：Breast cancer research and treatment

authors： Funk A,Heil J,Harcos A,Gomez C,Stieber A,Junkermann H,Hennigs A,Rauch G,Sinn HP,Riedel F,Schäfgen B,Hug S,Maier A,Blumenstein M,Domschke C,Schott S,Wallwiener M,Rom J,Schütz F,Sohn C,Golatta M

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Triple-negative breast cancers (TNBC) are aggressive tumours that exhibit abundant lymphoid infiltrates which modulate tumour behaviour. Recent findings suggest that TNBC with higher densities of plasma cells are associated with a favourable prognosis, and tertiary lymphoid structures (TLS) have prognostic sign...

journal_title：Breast cancer research and treatment

authors： Seow DYB,Yeong JPS,Lim JX,Chia N,Lim JCT,Ong CCH,Tan PH,Iqbal J

更新日期：2020-04-01 00:00:00

abstract：:A major goal of cancer chemotherapy is the identification of cytotoxic compounds that are highly selective for cancer cells. We describe here one such compound - a novel iron chelator, desferri-exochelin 772SM. This desferri-exochelin has unique chemical and pharmacological properties, including extremely high iron bi...

journal_title：Breast cancer research and treatment

authors： Pahl PM,Horwitz MA,Horwitz KB,Horwitz LD

更新日期：2001-09-01 00:00:00