The association between diabetes and breast cancer stage at diagnosis: a population-based study.


:Women with diabetes have higher breast cancer incidence and mortality. The purpose of this study was to examine the impact of diabetes on stage at breast cancer diagnosis, as a possible reason for their higher mortality. Using population-based health databases from Ontario, Canada, this retrospective cohort study examined stage at diagnosis (II, III, or IV vs I) among women aged 20-105 years who were newly diagnosed with invasive breast cancer between 2007 and 2012. We compared those with diabetes to those without diabetes. Diabetes was defined based on medical records using a validated algorithm. Among 38,407 women with breast cancer, 6115 (15.9 %) women had diabetes. Breast cancer patients with diabetes were significantly more likely to present with advanced-stage breast cancer than those without diabetes. After adjustment for mammograms and other covariates, diabetes was associated with a significantly increased risk of Stage II [adjusted odds ratio (aOR) 1.14, 95 % confidence interval (CI) 1.07, 1.22], Stage III (aOR 1.21, 95 % CI 1.11, 1.33), and Stage IV (aOR 1.16, 95 % CI 1.01, 1.33) versus Stage I breast cancer. Women with diabetes had a higher risk of lymph node metastases (aOR 1.16, 95 % CI 1.06, 1.27) and tumors with size over 2 cm (aOR 1.16, 95 % CI 1.06, 1.28). Diabetes was associated with more advanced-stage breast cancer, even after accounting for differences in screening mammogram use and other factors. Our findings suggest that diabetes may predispose to more aggressive breast cancer, which may be a contributor to their higher cancer mortality.


Lipscombe LL,Fischer HD,Austin PC,Fu L,Jaakkimainen RL,Ginsburg O,Rochon PA,Narod S,Paszat L




Has Abstract


2015-04-01 00:00:00












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    abstract::We examined the role of Mcl-1 and Bcl-2 expression in the induction of apoptosis. through blocking protein tyrosine kinase (PTK), protein kinase C (PKC), phosphatidylinositol 3-kinase (P13-K) and mitogen-activated protein kinase (MAPK)/Erk kinase (MEK) signaling pathways by various kinase inhibitors in MCF-7 breast ca...

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    pub_type: 杂志文章


    authors: Hu Y,Dragowska WH,Wallis A,Duronio V,Mayer L

    更新日期:2001-11-01 00:00:00

  • Tai chi for breast cancer patients: a systematic review.

    abstract::The objective of this review was to assess the effectiveness of tai chi for supportive breast cancer care. Eleven databases were searched from inception through December 2009. Controlled trials testing tai chi in patients with breast cancer that assessed clinical outcome measures were considered. The selection of stud...

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    pub_type: 杂志文章,评审


    authors: Lee MS,Choi TY,Ernst E

    更新日期:2010-04-01 00:00:00

  • Recurrent germline mutations in BRCA1 and BRCA2 genes in high risk families in Israel.

    abstract::The spectrum of germline mutations among Jewish non Ashkenazi high risk breast/ovarian cancer families includes a few predominant mutations in BRCA1 (185delAG and Tyr978X) and BRCA2 (8765delAG). A few additional recurring mutations [A1708E, 981delAT, C61G (BRCA1) R2336P, and IVS2 + 1G > A (BRCA2)] have been reported i...

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    authors: Laitman Y,Simeonov M,Herskovitz L,Kushnir A,Shimon-Paluch S,Kaufman B,Zidan J,Friedman E

    更新日期:2012-06-01 00:00:00

  • The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT.

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    pub_type: 杂志文章,随机对照试验


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    更新日期:2018-02-01 00:00:00

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    journal_title:Breast cancer research and treatment

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    authors: Binder C,Simon A,Binder L,Hagemann T,Schulz M,Emons G,Trümper L,Einspanier A

    更新日期:2004-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Koppelmans V,de Ruiter MB,van der Lijn F,Boogerd W,Seynaeve C,van der Lugt A,Vrooman H,Niessen WJ,Breteler MM,Schagen SB

    更新日期:2012-04-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Schmutzler RK,Sanchez M,Lehrer S,Chaparro CA,Phillips C,Rabin J,Schachter B

    更新日期:1991-10-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Zhi WI,Chen P,Kwon A,Chen C,Harte SE,Piulson L,Li S,Patil S,Mao JJ,Bao T

    更新日期:2019-12-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 社论


    authors: Ahmed M,Jozsa F,Douek M

    更新日期:2017-09-01 00:00:00

  • Analysis of chemotherapy-induced amenorrhea rates by three different anthracycline and taxane containing regimens for early breast cancer.

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    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章,随机对照试验


    authors: Han HS,Ro J,Lee KS,Nam BH,Seo JA,Lee DH,Lee H,Lee ES,Kang HS,Kim SW

    更新日期:2009-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Vergote D,Cren-Olivé C,Chopin V,Toillon RA,Rolando C,Hondermarck H,Le Bourhis X

    更新日期:2002-12-01 00:00:00

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    authors: Ye C,Shu XO,Wen W,Pierce L,Courtney R,Gao YT,Zheng W,Cai Q

    更新日期:2008-04-01 00:00:00

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    更新日期:2006-01-01 00:00:00

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    authors: Sizemore ST,Sizemore GM,Booth CN,Thompson CL,Silverman P,Bebek G,Abdul-Karim FW,Avril S,Keri RA

    更新日期:2014-07-01 00:00:00

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    authors: Weiss A,Grossmith S,Cutts D,Mikami SA,Suskin JA,Graichen MK,Rojas NA,Pace LE,Joyce E,Rhei E,Scheib R,Bychkovsky B,Garber JE,Morganstern D,King TA

    更新日期:2019-05-01 00:00:00

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    authors: Mansi JL,Earl HM,Powles TJ,Coombes RC

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    authors: Langsenlehner U,Renner W,Yazdani-Biuki B,Eder T,Wascher TC,Paulweber B,Clar H,Hofmann G,Samonigg H,Krippl P

    更新日期:2006-05-01 00:00:00

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    journal_title:Breast cancer research and treatment

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    authors: Ceriani R,Anderson EP

    更新日期:1985-01-01 00:00:00

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    authors: Van den Eynden GG,Van Laere SJ,Van der Auwera I,Merajver SD,Van Marck EA,van Dam P,Vermeulen PB,Dirix LY,van Golen KL

    更新日期:2006-02-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    更新日期:2017-02-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Fink BN,Gaudet MM,Britton JA,Abrahamson PE,Teitelbaum SL,Jacobson J,Bell P,Thomas JA,Kabat GC,Neugut AI,Gammon MD

    更新日期:2006-07-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 临床试验,杂志文章


    authors: Watanabe J,Saito M,Horimoto Y,Nakamoto S

    更新日期:2020-05-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Nakamura Y,Yasuoka H,Tsujimoto M,Imabun S,Nakahara M,Nakao K,Nakamura M,Mori I,Kakudo K

    更新日期:2005-05-01 00:00:00

  • Controlled release low dose medroxyprogesterone acetate (MPA) inhibits the development of mammary tumors induced by dimethyl-benz(a) anthracene in the rat.

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    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Labrie F,Li S,Bélanger A,Côté J,Mérand Y,Lepage M

    更新日期:1993-01-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Reid AD,Horobin JM,Newman EL,Preece PE

    更新日期:1992-01-01 00:00:00

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    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: To SQ,Simpson ER,Knower KC,Clyne CD

    更新日期:2013-02-01 00:00:00

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    abstract::Manganese superoxide dismutase (MnSOD) is known to play a role in cancer. MnSOD exerts a tumor suppressive effect in estrogen-dependent human breast cancer cells. In the present study we investigated the in vitro role of MnSOD in the growth of some aggressive and highly metastatic estrogen-independent breast cancer ce...

    journal_title:Breast cancer research and treatment

    pub_type: 杂志文章


    authors: Kattan Z,Minig V,Leroy P,Dauça M,Becuwe P

    更新日期:2008-03-01 00:00:00