Evaluation of intestinal mucosal permeability function in patients with acute pancreatitis.

Abstract:

:This study aims to evaluate the intestinal mucosal permeability in patients with acute pancreatitis. The lactulose:mannitol (L:M) ratio was used to assess permeability. It is an inexpensive and quite reliable method. The intestinal permeability was increased in patients with acute pancreatitis compared with the controls. In addition, patients with severe pancreatitis had higher intestinal barrier dysfunction compared with patients with mild pancreatitis, the L:M ratio being .2 and .029, respectively. It was also concluded that the permeability increased gradually over the course of pancreatitis and was maximum at day 7 (P < .01). This provides a window of opportunity for therapeutic intervention to prevent the late observed increase in intestinal permeability.

journal_name

Am J Surg

authors

Nagpal K,Minocha VR,Agrawal V,Kapur S

doi

10.1016/j.amjsurg.2006.02.001

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

24-8

issue

1

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(06)00077-8

journal_volume

192

pub_type

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