Inadequacy of steroids in the treatment of severe hemorrhagic shock.

Abstract:

:Massive doses of methylprednisolone were given to dogs prior to severe, lethal, hemorrhagic shock. An untreated group of dogs subjected to hemorrhagic shock served as controls. No persistent significant differences were seen in cardiac output, mean arterial blood pressure, superior mesenteric artery flow, and survival. Calculated total peripheral resistance tended to be lower in the treated dogs and was significantly lower after reinfusion of shed blood. Pretreatment with methylprednisolone did not prevent plasma elevations of the lysosomal enzymes, cathepsin D and beta-glucuronidase. Stabilization of hepatic lysosomes in treated dogs subjected to hemorrhagic shock was not evident. The results failed to indicate significant salutary effects of methylprednisolone sodium succinate in this lethal hemorrhagic shock model.

journal_name

Am J Surg

authors

Raflo GT,Jones RC Jr,Wangensteen SL

doi

10.1016/0002-9610(75)90394-3

subject

Has Abstract

pub_date

1975-09-01 00:00:00

pages

321-7

issue

3

eissn

0002-9610

issn

1879-1883

pii

0002-9610(75)90394-3

journal_volume

130

pub_type

杂志文章
  • Evaluation of readmissions due to surgical site infections: A potential target for quality improvement.

    abstract:INTRODUCTION:Readmissions have become a focus of pay-for-performance programs. Surgical site infections (SSI) are the reason for most readmissions. Readmissions for SSI could be a unique target for quality improvement. METHODS:Readmission risk for SSI were evaluated for patients undergoing colectomies from 2013 to 201...

    journal_title:American journal of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.amjsurg.2017.04.011

    authors: Shah R,Pavey E,Ju M,Merkow R,Rajaram R,Wandling MW,Cohen ME,Dahlke A,Yang A,Bilimoria K

    更新日期:2017-11-01 00:00:00

  • Practice referral patterns and outcomes in patients with primary retroperitoneal sarcoma in British Columbia.

    abstract:BACKGROUND:We examined practice referral patterns for primary retroperitoneal sarcoma (PRS) in British Columbia (BC) and associations between the timing of referral to tertiary care and patient outcomes. METHODS:Using ICD-10 coding, the Cancer Agency Information System was used to identify patients with PRS from 2000 ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2012.01.006

    authors: Merchant S,Cheifetz R,Knowling M,Khurshed F,McGahan C

    更新日期:2012-05-01 00:00:00

  • Natural history of the leg amputee.

    abstract::For 173 patients undergoing major leg amputations, the operative mortality was 13 per cent. The ratio of below-knee (BK) to above-knee (AK) amputations was approximately unity. Of the 150 patients who survived amputation, 93 were given prostheses. Amoung the latter group, 76 per cent of the unilateral AK amputees and ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(77)90133-7

    authors: Couch NP,David JK,Tilney NL,Crane C

    更新日期:1977-04-01 00:00:00

  • The value of clinical characteristics and breast-imaging studies in predicting a histopathologic diagnosis of cancer or high-risk lesion in patients with spontaneous nipple discharge.

    abstract:BACKGROUND:The purpose of this study was to determine the utility of breast-imaging studies in identifying cancer and high-risk lesions among patients with spontaneous, single-duct, nipple discharge (SSND). METHODS:The medical records of 168 cases with SSND treated with duct excision between June 1998 and May 2004 wer...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2005.06.032

    authors: Adepoju LJ,Chun J,El-Tamer M,Ditkoff BA,Schnabel F,Joseph KA

    更新日期:2005-10-01 00:00:00

  • Three-phase study of phlebitis in patients receiving peripheral intravenous hyperalimentation.

    abstract::We found clinical phlebitis in 57 of 88 patients with peripheral hyperalimentation (65%). To determine if this was a problem common to all intravenous fluid therapy at our hospital, we performed a point-prevalence study. The prevalence of phlebitis in nonhyperalimentation intravenous patients was 18% (84 of 456 patien...

    journal_title:American journal of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-9610(05)80266-1

    authors: Rypins EB,Johnson BH,Reder B,Sarfeh IJ,Shimoda K

    更新日期:1990-02-01 00:00:00

  • Complications of negative laparotomy for trauma.

    abstract::Controversy continues about how often a negative laparotomy should be accepted in the management of patients with blunt and penetrating trauma. A key issue is the complications, especially small bowel obstruction. To define these complications, the charts of 248 patients who underwent negative laparotomy for trauma we...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(88)80549-x

    authors: Weigelt JA,Kingman RG

    更新日期:1988-12-01 00:00:00

  • Acute traumatic rupture of the descending thoracic aorta: endovascular treatment.

    abstract:BACKGROUND:Acute traumatic rupture of the descending thoracic aorta is usually considered a surgical emergency; a conventional surgical approach carries high morbidity and mortality rates in the perioperative period. Endovascular surgery has recently been considered as providing a new therapeutic strategy for these pat...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2006.01.048

    authors: Pratesi C,Dorigo W,Troisi N,Pratesi G,Santoro G,Stefano P,Innocenti AA,Pulli R

    更新日期:2006-09-01 00:00:00

  • The efficacy of antibiotic treatment versus surgical treatment of uncomplicated acute appendicitis: Systematic review and network meta-analysis of randomized controlled trial.

    abstract:BACKGROUND:The efficacy of antibiotics in appendicitis remains controversial, and physicians are not confident in prescribing antibiotics as the first line treatment. This network meta-analysis was conducted to assess the efficacy and safety of individual antibiotics in uncomplicated appendicitis. METHODS:Randomized c...

    journal_title:American journal of surgery

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.amjsurg.2018.10.009

    authors: Poprom N,Numthavaj P,Wilasrusmee C,Rattanasiri S,Attia J,McEvoy M,Thakkinstian A

    更新日期:2019-07-01 00:00:00

  • The impact of medical student interest in surgery on clerkship performance and career choice.

    abstract:BACKGROUND:Interest in surgery has declined for two decades. This study aimed to evaluate the impact of one's interest in surgery on career choice. METHODS:Students who completed the surgical clerkship (2016-2017) were invited to complete surveys assessing rotation experience, learning style, burnout, and grit. Studen...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2019.09.040

    authors: Kassam AF,Cortez AR,Winer LK,Kuethe JW,Athota KP,Quillin RC 3rd

    更新日期:2020-02-01 00:00:00

  • Misplaced pancreatic duct orifice as a cause of recurrent acute pancreatitis.

    abstract::Acute recurrent pancreatitis in the absence of alcoholism and gallstones is a frustrating illness for both the patient and the physician. Over a 10 year period, 33 patients were operated on and found to have a duct of Wirsung entering the duodenum through the fibers of the sphincter of Oddi. Recurrent pancreatitis of ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(87)90808-7

    authors: Carey LC

    更新日期:1987-02-01 00:00:00

  • Therapeutic significance of noncurative gastrectomy for gastric cancer with liver metastasis.

    abstract::The therapeutic significance of noncurative gastrectomy for gastric cancer with liver metastasis was evaluated and the histologic characteristics of such cancer examined. The mean postoperative survival time of patients with liver metastasis limited to one lobe or a few scattered metastases to both lobes without perit...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(80)90167-1

    authors: Koga S,Kawaguchi H,Kishimoto H,Tanaka K,Miyano Y,Kimura O,Takeda R,Nishidoi H

    更新日期:1980-09-01 00:00:00

  • Impact of intraoperative myocardial tissue acidosis on postoperative adverse outcomes and cost of care for patients undergoing prolonged aortic clamping during cardiopulmonary bypass.

    abstract:BACKGROUND:This study examined the impact of intraoperative myocardial acidosis and adverse postoperative outcomes on the cost of cardiac surgical care. METHODS:Myocardial tissue pH corrected to 37 degrees C (pH(37C)) was measured in 162 patients with cross-clamp (XC) duration of 119 minutes or longer. Perioperative d...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2008.01.023

    authors: Healey CM,Kumbhani DJ,Healey NA,Crittenden MD,Gibson SF,Khuri SF

    更新日期:2009-02-01 00:00:00

  • Stapled hemorrhoidopexy height as outcome indicator.

    abstract:BACKGROUND:Postoperative expectations after stapled hemorrhoidopexy are still being clarified. Our purpose was to evaluate how outcome is affected by staple line height (SLH) above the dentate line and specimen histology. METHODS:A prospective database identified demographics, SLH, histology, narcotic use, return to w...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2006.09.015

    authors: Williams R,Kondylis L,Geisler D,Kondylis P

    更新日期:2007-03-01 00:00:00

  • The gut as source of sepsis after hemorrhagic shock.

    abstract::In a model of severe hemorrhagic shock in rats, blood culture findings became positive within 2 to 4 hours of shock. The organisms cultured were primarily gram-negative. To test the hypothesis that the gut was the source of the bacteria, E. coli labeled with carbon-14 oleic acid were fed to rats undergoing hemorrhagic...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(88)80691-3

    authors: Sori AJ,Rush BF Jr,Lysz TW,Smith S,Machiedo GW

    更新日期:1988-02-01 00:00:00

  • Synchronous non-small cell lung cancers.

    abstract:INTRODUCTION:The few series of synchronous lung cancers have included small cell and carcinoid tumors. We wished to determine the prognosis for patients with synchronous non-small cell lung cancer (NSCLC). METHODS:A database of 3034 lung cancer patients was reviewed for synchronous NSCLC. Survival was determined by Ka...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/S0002-9610(96)00019-0

    authors: Pommier RF,Vetto JT,Lee JT,Johnston KM

    更新日期:1996-05-01 00:00:00

  • Major complications of angioaccess surgery.

    abstract::Angioaccess procedures at one institution over a 4-year period were retrospectively reviewed to ascertain the frequency of major limb- or life-threatening complications. A total of 435 angioaccess procedures were performed, including 81 Cimino-Brescia fistulas, 166 polytetrafluoroethylene grafts, and 111 thrombectomy/...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(05)81076-1

    authors: Ballard JL,Bunt TJ,Malone JM

    更新日期:1992-09-01 00:00:00

  • Comparing 20 years of national general surgery malpractice claims data: obesity versus morbid obesity.

    abstract:BACKGROUND:We hypothesized that the increasing body mass index of the population has affected general surgery malpractice claims. METHODS:We queried the Physician Insurers Association of America database from 1990 to 1999 (ie, period 1) and 2000 to 2009 (ie, period 2) for claims associated with obesity and morbid obes...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2012.10.023

    authors: Weber CE,Talbot LJ,Geller JM,Kuo MC,Wai PY,Kuo PC

    更新日期:2013-03-01 00:00:00

  • Drug therapy for inflammatory bowel disease: Part II.

    abstract::Part II of this two-part article (See The American Journal of Surgery 1992; 164: 85-9) reviews the current definition of the role of immunosuppressive therapy in inflammatory bowel disease (IBD) and the use of antibiotics in IBD, as well as summarizes the uses of the new agents on the horizon for the treatment of IBD....

    journal_title:American journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s0002-9610(05)80381-2

    authors: Linn FV,Peppercorn MA

    更新日期:1992-08-01 00:00:00

  • A cost analysis of a pancreatic cancer screening protocol in high-risk populations.

    abstract:BACKGROUND:Pancreatic cancer is the 4th leading cause of cancer death in the United States. A screening protocol is needed to catch early-stage, resectable disease. This study suggests a protocol for high-risk individuals and assesses the cost in the context of the Affordable Care Act. METHODS:Medicare and national av...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2014.11.017

    authors: Bruenderman E,Martin RC 2nd

    更新日期:2015-09-01 00:00:00

  • Jejunoileal bypass. Late metabolic sequelae and weight gain.

    abstract::Of 101 patients originally operated on, the status of 98 is known. Given the mortality and reanastomosis rates, the operation must be considered an absolute failure in 28 percent of the patients. Given the other complications that appear (or persist) late postoperatively, only 18 percent of the entire series of patien...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(80)90165-8

    authors: Halverson JD,Scheff RJ,Gentry K,Alpers DH

    更新日期:1980-09-01 00:00:00

  • Pancreaticoduodenectomy for nonperiampullary primary tumors.

    abstract:INTRODUCTION:This review was performed to evaluate the outcome of patients undergoing pancreaticoduodenectomy (PD) for isolated metastatic or locally advanced nonperiampullary tumors at a single institution over a 13-year period. METHODS:Between 1983 and 1996, patients undergoing PD for metastatic or locally advanced ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(97)00121-9

    authors: Harrison LE,Merchant N,Cohen AM,Brennan MF

    更新日期:1997-10-01 00:00:00

  • Pneumomediastinum in blunt trauma: If aerodigestive injury is not seen on CT, invasive workup is not indicated.

    abstract:BACKGROUND:Pneumomediastinum following blunt trauma is often observed on CT imaging, and concern for associated aerodigestive injury often prompts endoscopy and/or fluoroscopy. In recent years, adoption of multi-detector CT technology has resulted in high resolution images that may clearly identify aerodigestive injuri...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2018.11.002

    authors: Matthees NG,Mankin JA,Trahan AM,Israr S,Jones MD,Dameworth JL,Petersen SR,Weinberg JA

    更新日期:2019-06-01 00:00:00

  • Vertical banded gastroplasty as an antireflux procedure.

    abstract::Vertical banded gastroplasty creates a channel by two applications of the TA-90 stapler from an end-to-end anastomosis window above the crow's foot to the angle of His, against a 32 F. tube along the lesser curvature. The caudad end of the channel is restricted by a 5 cm collar. Thirty-one obese patients more than 45 ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(88)80125-9

    authors: Deitel M,Khanna RK,Hagen J,Ilves R

    更新日期:1988-03-01 00:00:00

  • In situ saphenous vein bypass grafting. Experience in 34 extremities over a 2 year period.

    abstract::Over a 2 year period, 34 limbs were revascularized in 33 patients. The in situ saphenous vein technique was used. Improved instrumentation and patency rates have encouraged the use of this method. Eighteen patients were insulin-dependent diabetics. The indication for operation was limb salvage in 25 limbs (73 percent)...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(83)90108-3

    authors: Hallin RW

    更新日期:1983-05-01 00:00:00

  • A simplified technique for laparoscopic jejunostomy and gastrostomy tube placement.

    abstract:BACKGROUND:Percutaneous endoscopic gastrostomy and jejunostomy tube placement have long been considered the standard for supplying enteral nutrition when oral intake is not possible. Both have well-documented roles and limitations and are associated with a higher than generally appreciated incidence of aspiration. A di...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(98)00298-0

    authors: Rosser JC Jr,Rodas EB,Blancaflor J,Prosst RL,Rosser LE,Salem RR

    更新日期:1999-01-01 00:00:00

  • Vascular ultrasonography prior to dialysis access surgery.

    abstract:BACKGROUND:Native arterial venous fistulas (NAVF) are generally considered preferable to synthetic grafts for chronic dialysis access. As increasing numbers of diabetic and elderly patients are treated, adequate NAVFs become more difficult to establish. Vascular ultrasonography (US) prior to NAVF surgery has received l...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(02)01103-0

    authors: Parmley MC,Broughan TA,Jennings WC

    更新日期:2002-12-01 00:00:00

  • Preoperative irradiation potentiation with cisplatin: effect on rate of wound infection.

    abstract::Platinum coordination complexes, such as cisplatin, potentiate the cytotoxicity of irradiation on squamous cell carcinoma and certain other solid tumors. Using a rat oro-cutaneous fistula model, an investigation was carried out to determine whether or not there was a concomitant potentiation with cisplatin of the dele...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(86)90322-3

    authors: Morain WD,Richmond RC,Jacobs NJ,Douple EB,Coughlin CT

    更新日期:1986-10-01 00:00:00

  • Mandibular reconstruction with composite microvascular tissue transfer.

    abstract::Microvascular free tissue transfer has provided a variety of methods of restoring vascularized bone and soft tissue to difficult defects created by tumor resection and trauma. Over 7 years, 26 patients have undergone 28 free flaps for mandibular reconstruction, 15 for primary squamous cell carcinoma of the floor of th...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(05)80550-1

    authors: Coleman JJ 3rd,Wooden WA

    更新日期:1990-10-01 00:00:00

  • Spontaneous hepatic rupture in pregnancy.

    abstract::Hepatic rupture as a late complication of toxemic pregnancy is a rare yet lethal condition requiring rapid recognition and surgical management. The clinical triad of toxemia, right upper quadrant pain, and sudden hypotension is the diagnostic hallmark of presentation. Most patients present near the time of delivery an...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(77)90333-6

    authors: Nelson EW,Archibald L,Albo D Jr

    更新日期:1977-12-01 00:00:00

  • Rural surgeons' perspectives on necessity of post-residency training are stable across generations.

    abstract:BACKGROUND:Training future rural surgeons is critical, but training needs are unclear. We hypothesize perspectives on necessity of subspecialty training differ among rural surgeons by generational cohort. METHODS:An online survey was sent to ACS Rural Surgery Listserv subscribers. Closed-ended elements were analyzed u...

    journal_title:American journal of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.amjsurg.2018.11.026

    authors: Hughes D,Cook MR,Deal SB,Hughes TG,Sarap M,Brasel K,Alseidi A

    更新日期:2019-02-01 00:00:00