Preoperative irradiation potentiation with cisplatin: effect on rate of wound infection.

Abstract:

:Platinum coordination complexes, such as cisplatin, potentiate the cytotoxicity of irradiation on squamous cell carcinoma and certain other solid tumors. Using a rat oro-cutaneous fistula model, an investigation was carried out to determine whether or not there was a concomitant potentiation with cisplatin of the deleterious effect of preoperative irradiation on the ability of a subsequent wound to handle a bacterial challenge. Auto-contaminated wounds were found to have increased rates of infection at single-dose orthovoltage pretreatments of 1,500 rads or more. Using quantitative bacteriologic techniques, would infection was found to be no more frequent after platinum-enhanced irradiation than after irradiation alone; however, there was the additive effect of weight loss associated with combined cisplatin treatment and irradiation.

journal_name

Am J Surg

authors

Morain WD,Richmond RC,Jacobs NJ,Douple EB,Coughlin CT

doi

10.1016/0002-9610(86)90322-3

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

446-50

issue

4

eissn

0002-9610

issn

1879-1883

pii

0002-9610(86)90322-3

journal_volume

152

pub_type

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