Treatment-refractory schizophrenia.

Abstract:

PURPOSE OF REVIEW:The aim of this article is to critically review the current literature on treatment-refractory schizophrenia with an emphasis on emergent themes and key findings. RECENT FINDINGS:New information continues to emerge on the impact of each second-generation antipsychotic on the treatment-refractory patient population and on the traditionally more difficult-to-treat components (e.g. cognition, suicidality, violence) of the illness. There are continued efforts with pharmacogenetics to predict response and side-effect risk with antipsychotic medications. Polypharmacy continues to be a major and poorly understood treatment practice. SUMMARY:Our field is advancing the therapeutic nuances of therapy with second-generation antipsychotics in treatment-refractory schizophrenia. Additionally, there is a growing appreciation of the emergent adverse-effect profile of antipsychotic medications and these risk-benefit considerations are more pronounced in severely ill patients.

journal_name

Curr Opin Psychiatry

authors

Buckley PF,Shendarkar N

doi

10.1097/00001504-200503000-00010

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

165-73

issue

2

eissn

0951-7367

issn

1473-6578

pii

00001504-200503000-00010

journal_volume

18

pub_type

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