Abstract:
PURPOSE OF REVIEW:The aim of this article is to critically review the current literature on treatment-refractory schizophrenia with an emphasis on emergent themes and key findings. RECENT FINDINGS:New information continues to emerge on the impact of each second-generation antipsychotic on the treatment-refractory patient population and on the traditionally more difficult-to-treat components (e.g. cognition, suicidality, violence) of the illness. There are continued efforts with pharmacogenetics to predict response and side-effect risk with antipsychotic medications. Polypharmacy continues to be a major and poorly understood treatment practice. SUMMARY:Our field is advancing the therapeutic nuances of therapy with second-generation antipsychotics in treatment-refractory schizophrenia. Additionally, there is a growing appreciation of the emergent adverse-effect profile of antipsychotic medications and these risk-benefit considerations are more pronounced in severely ill patients.
journal_name
Curr Opin Psychiatryjournal_title
Current opinion in psychiatryauthors
Buckley PF,Shendarkar Ndoi
10.1097/00001504-200503000-00010subject
Has Abstractpub_date
2005-03-01 00:00:00pages
165-73issue
2eissn
0951-7367issn
1473-6578pii
00001504-200503000-00010journal_volume
18pub_type
杂志文章abstract:PURPOSE OF REVIEW:Economic evaluation is becoming more and more important as a means to assist policy makers in choosing the best intervention or treatment against a pervasive scarcity of resources relative to the demands. Health service provision and the practice of geriatric psychiatry are closely associated with cos...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32830f1bd5
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Psychiatric neuroimaging has made a dramatic impact on the understanding of the brain in mental illness in a relatively brief period of time and continues to be evolving in terms of methodology, analysis and utilization of the combination of techniques. Given the level of sophistication of the techniq...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/01.yco.0000245750.98749.1b
更新日期:2006-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to summarize data published in the scientific literature and available on official websites on fetal alcohol spectrum disorder (FASD) in Africa. RECENT FINDINGS:There is a paucity of published literature and evidence-based information on prenatal exposure to alcohol in the African co...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000315
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:We reviewed the recent literature on prevalence rates, and application of evidence-based treatments for eating disorders among Hispanics/Latinos residing in the United States. RECENT FINDINGS:Lifetime prevalence rates of anorexia nervosa are lower among Hispanic/Latinos than non-Hispanic Whites. Ther...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000277
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Specific phobias are prevalent and often disabling anxiety disorders. The present review examines relevant investigations that have been published during the last 2 years on major aspects of this group of disorders. RECENT FINDINGS:Recent studies have come mainly from epidemiology, brain imagery and ...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3282f30086
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Since the first description of the foetal damage of alcohol in 1967, numerous studies have outlined different aspects of neurodevelopmental dysfunction, adversely affecting the lives of children worldwide. Although the cause of the syndrome is sorted out, the pathogenesis of brain damage is far from b...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000038
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to describe the considerable advances in consolidating the empirical evidence on several key topics in the genetics of attention deficit hyperactivity disorder, namely the quantitative genetic studies of the nature of attention deficit hyperactivity disorder and its comorbidi...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328303ba54
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Schizophrenia occurs in ∼25% of individuals with 22q11.2 deletion syndrome (22q11.2DS), the strongest known molecular genetic risk factor for schizophrenia. This review highlights recent literature in 22q11.2DS as it pertains to psychosis and schizophrenia. RECENT FINDINGS:Advances in noninvasive pre...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000324
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:With increasing awareness of potential differences of autism presentation in nonmale versus male individuals, this review summarizes the rapidly evolving literature on sex and gender impacts on autism across nosology, behavioural presentation, developmental change and contextual recognition biases. R...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000575
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The nomenclature and classification of somatoform disorders have undergone revisions in the fifth edition of the Diagnostic and Statistical Manual (DSM 5) and the upcoming eleventh edition of the International Classification of Diseases (ICD-11). The present review describes the changes that have evol...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000630
更新日期:2020-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Cognitive dysfunction in major depressive disorder (MDD) is common, pervasive across multiple subdomains of cognitive function, and is a principle determinant of health outcomes from patient, provider, and societal perspectives. The overarching aim herein is to provide rationale for the evaluation, me...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000221
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Alcohol dependence is a complex disorder with a well documented highly hereditary nature. This article reviews the recent advances in our understanding of the direct and indirect genetic influences on alcohol use and dependence. RECENT FINDINGS:Recent findings can be summarized as follows: (a) twin s...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/01.yco.0000218595.54054.7a
更新日期:2006-05-01 00:00:00
abstract:PURPOSE OF REVIEW:In this paper, we analyze the concept of objectivity as it is accepted in the 'standard position' on ethical practice in forensic psychiatry and confront it with the current trends of psychiatric nosology, specially the debate that we have now regarding the theoretical orientation of DSM-5, which is i...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32833cd1e6
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Considerable progress has been made in the neurobiological understanding of expectations in physiological and pathological processes. This article is aimed at presenting an overview of the role of expectations in producing health-related effects. We selected recent laboratory and clinical studies in t...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328343803b
更新日期:2011-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update of the recent studies on the olfactory function in Alzheimer's disease, with a focus on the olfactory identification function. RECENT FINDINGS:The studies reviewed here confirm previous reports on the poor olfactory function in Alzheimer's disease compared to health normal contro...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000146
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:There has been increased interest in the relationship between religion and spirituality and mental health in recent years. This article reviews recent research into the capacity of religion and spirituality to benefit or harm the mental health of believers. We also examine the implications this may ha...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000080
更新日期:2014-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review focuses on atypical antipsychotics and tardive dyskinesia. RECENT FINDINGS:We have known for many years that clozapine has a diminished risk of tardive dyskinesia compared with typical antipsychotics. The last decade has seen the introduction of a number of other atypical antipsych...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328017f6b1
更新日期:2007-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Depression is a common and disabling disorder that affects people of all ages and 10% of those older than 65 years. Current strategies to decrease the personal and societal burden of depression in older age rely on the management of people with depression or of those at risk, but benefits have been li...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328356bd57
更新日期:2012-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Arts therapies are still inadequately regulated throughout the world despite a 100-year-long tradition, a vast number of academically trained therapists and importance in treating psychiatric patients. It is essential that more evidence-based studies are undertaken. RECENT FINDINGS:Current internatio...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000338
更新日期:2017-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Neuroimaging research in psychiatry has been increasing exponentially in recent years, yet many psychiatrists are relatively unfamiliar with this field. This article summarizes the findings of the most relevant research articles on the neuroimaging of somatoform, conversive, and dissociative disorders...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283252d43
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review presents the latest developments covered in the literature regarding psychosis in neurodegenerative disorders and discusses possible future research directions. RECENT FINDINGS:Recent findings in the field of psychosis and neurodegenerative disorders revolve around four main themes. The f...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000476
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Social cognition training is an emerging intervention, which aims to ameliorate impairment in social interaction and improve functional outcomes in persons with a psychosis. This article reviews the research conducted on the impact of this intervention published in English language journals over the p...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283642cf1
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review highlights the epidemiologic research on club drug use in the past year, with a focus on clinical epidemiology, social epidemiology, new methodological approaches, and alternative explanations for drug use behaviors. RECENT FINDINGS:Although 3,4-methylenedioxy-N-methylamphetamine (MDMA) o...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,多中心研究,评审
doi:10.1097/YCO.0b013e3282f9b1f1
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This review considers the literature on ethical and conceptual issues in eating disorders from the last 18 months. Some reference to earlier work is necessary in order to provide context for the recent findings from research that is ongoing. RECENT FINDINGS:Empirical ethics research on anorexia nervo...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328365a3a1
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent progress in the diagnosis and management of irritable bowel syndrome, with a focus on dietary and microbiota aspects. RECENT FINDINGS:From a pathophysiological point of view, IBS is a multifactorial condition with both peripheral (transit) as central (visceral hypersensi...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000628
更新日期:2020-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Screening measures for bipolar disorder are positioned as playing an important role in improving diagnostic accuracy. This review considers the principal screening measures developed over the past decade. RECENT FINDINGS:Although the development and evaluation of bipolar screening measures were disti...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000125
更新日期:2015-01-01 00:00:00
abstract:PURPOSE OF REVIEW:In many regions of the world, wives of alcohol and drug-using men are at an increased risk for HIV/AIDS because of their husbands' high-risk behaviours. These women also tend to be poor, illiterate and dependent on their husbands. Few interventions are designed exclusively for these women. Furthermore...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328361ebd7
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Schizophrenia (SCZ) and bipolar disorder are severe mental disorders, both placing a significant burden on individuals' wellbeing and global health generally. The complex interaction of multiple mechanisms, underlying these disorders, still needs further elucidation. Increased activation of components...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000499
更新日期:2019-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Behavioral medicine is a vast field with an ever-increasing knowledge base. We review important findings over the last 18 months. RECENT FINDINGS:We organized advances in behavioral medicine into four main topic areas: the doctor and patient, health-related behavior, integration of behavioral medicin...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283503576
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Chronological age is a crude measure and may not be the best indicator of the ageing process. Establishing valid and reliable biomarkers to understand the true effect of ageing is of great interest. We provide an overview of biological and psychological characteristics that change with age and can pot...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000473
更新日期:2019-03-01 00:00:00