Abstract:
:Biological activity of thioaurones was not tested so far and the group constitute completely unexplored source of new molecules of pharmacological interest. We report synthesis and evaluation of cytotoxic activity of thioaurone derivatives bearing p-hydroquinone system in ring A. Their activity was found to depend strongly on substitution pattern, so eventually both the activity and pharmacokinetic parameters of the molecules could be tailored by further structural modifications.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Konieczny MT,Konieczny W,Okabe S,Tsujimoto H,Suda Y,Wierzba Kdoi
10.1248/cpb.54.350subject
Has Abstractpub_date
2006-03-01 00:00:00pages
350-3issue
3eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/54.350journal_volume
54pub_type
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