Abstract:
:Activation of the Akt/PKB protein kinase family triggers increases in cell size, metabolism and survival. Akt coordinately regulates these fundamental cellular processes through phosphorylation-dependent inactivation of tumor suppressors and activation of trophic signaling. Akt signaling stimulates transport and metabolism of both glucose and amino acids, which in turn support mTOR-dependent increases in protein translation. In addition, Akt activation directs cells to undertake a metabolic conversion from oxidative phosphorylation to aerobic glycolysis. Although this conversion promotes cell growth, it also renders cell survival dependent on a continuous supply of extracellular nutrients, which themselves are required regulatory elements in Akt signal transduction.
journal_name
Oncogenejournal_title
Oncogeneauthors
Plas DR,Thompson CBdoi
10.1038/sj.onc.1209097subject
Has Abstractpub_date
2005-11-14 00:00:00pages
7435-42issue
50eissn
0950-9232issn
1476-5594pii
1209097journal_volume
24pub_type
杂志文章,评审相关文献
ONCOGENE文献大全abstract::Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest th...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.570
更新日期:2015-01-02 00:00:00
abstract::BRCA1 mutation carriers have an increased susceptibility to breast and ovarian cancer. Excision of exon 11 of Brca1 in the mouse, using a conditional knockout (Cre-loxP) approach, results in mammary tumor formation after long latency. To characterize the genomic instability observed in these tumors, to establish a com...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205636
更新日期:2002-08-01 00:00:00
abstract::The Ets transcription factor PU.1 is a hematopoietic master regulator essential for the development of myeloid and B-cell lineages. As we previously reported, PU.1 sometimes represses transcription on forming a complex with mSin3A-histone deacetyl transferase-MeCP2. Here, we show an interaction between PU.1 and DNA me...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209272
更新日期:2006-04-20 00:00:00
abstract::The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Cancer reflects the progressive accumulation of genetic alterations and subsequent genetic instability of cells. Cytogenetic studies have demonstrated the importance of aneuploidy in differentiated thyroid cancer development. The pituitary tumour transforming gene (PTTG), also known as securin, is a mitotic checkpoint...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208659
更新日期:2005-07-14 00:00:00
abstract::Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myelogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloprolifera...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207673
更新日期:2004-05-24 00:00:00
abstract::c-Myc overexpression has been associated with several types of human cancers. To study the role of c-myc in epidermal differentiation and carcinogenesis, a transgenic mouse model was created to overexpress c-Myc in the epidermis. Human c-myc 2 cDNA was subcloned into a 6.5 kb mouse loricrin expression vector, ML.myc2....
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203040
更新日期:1999-08-26 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) causes fibrosis, cancer progression and metastasis. Integrin-linked kinase (ILK) is a focal adhesion adaptor and a serine/threonine protein kinase that regulates cell proliferation, survival and EMT. Elucidating the molecular mechanisms necessary for development and progressi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.30
更新日期:2013-01-03 00:00:00
abstract::The tumor suppressor transcription factor IRF-1 inhibits cell growth. In this report we show that IRF-1 also induces apoptosis of highly transformed and tumorigenic cell lines. This activity of IRF-1 is demonstrated with cell lines expressing HER oncogenes and an activatable IRF-1 fusion protein. Growth of cell lines ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202704
更新日期:1999-06-24 00:00:00
abstract::Rel/NF-kappaB transcription factors are involved in several physiological processes, including the regulation of apoptosis. These factors were shown to exhibit pro- or anti-apoptotic activities in different cellular models, but at present, the mechanisms underlying these opposite effects are poorly understood. In this...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205536
更新日期:2002-06-27 00:00:00
abstract::Signal transduction and activator of transcription 3(STAT3) signaling is constitutively activated in various tumors, and is involved in cell survival and proliferation during oncogenesis. There are few reports, however, on the role of STAT3 signaling in gastric cancer. The aim of the present study was to clarify the r...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207606
更新日期:2004-06-17 00:00:00
abstract::The simian double strand DNA tumor virus SV40 encodes the 90-kDa multi-functional protein, large T antigen (LT). LT functions by binding to DNA, as well as to many cellular target proteins such as p53 and retinoblastoma protein (pRB). We report here the identification of a cellular heat shock protein, HSP90, as a prev...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203475
更新日期:2000-03-09 00:00:00
abstract::Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.375
更新日期:2010-02-04 00:00:00
abstract::PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor regulates a variety of cellular processes including cell proliferation, growth, migration and death. This master regulator itself is also under deliberative regulation. Although the evidence for PTEN regulation and its significance in norm...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2008.242
更新日期:2008-09-18 00:00:00
abstract::The Mucin 1 (MUC1) protein is overexpressed in various cancers and mediates chemotherapy resistance. However, the mechanism is not fully understood. Given that most chemotherapeutic drugs disrupt ER homeostasis as part of their toxicity, and MUC1 expression is regulated by proteins involved in ER homeostasis, we inves...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1225-4
更新日期:2020-04-01 00:00:00
abstract::Expression of the p75 neurotrophin receptor (p75(NTR)) in primary melanomas is associated with deeply invasive lesions. In turn, there is expression of high levels of neurotrophins at the invasion front of normal tissue adjacent to brain metastases, thus implicating this growth factor-receptor system in melanoma tumor...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206561
更新日期:2003-06-05 00:00:00
abstract::Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted therapy. We used microarray analysis to perform a pathway analysis of TNBC compared with non-triple negative breas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.145
更新日期:2011-10-27 00:00:00
abstract::The ability of Src-family kinases (SFKs) to mediate signaling from cell surface receptors in hematopoietic cells is a function of their catalytic activity, location and binding partners. Kinase activity is regulated in the cell by kinases and phosphatases that alter the state of phosphorylation of key tyrosine residue...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208078
更新日期:2004-10-18 00:00:00
abstract::Although activation of the STAT3 pathway has been associated with tumor progression in a wide variety of cancer types (including ovarian cancer), the precise mechanism of invasion and metastasis due to STAT3 are not fully delineated in ovarian cancer. We found that pSTAT3 Tyr705 is constitutively activated in patient ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.197
更新日期:2017-01-12 00:00:00
abstract::Ras-genes encode for proteins important for transmitting extracellular signals from the cytoplasm to the nucleus. In this study we investigated the impact of Ras on cell cycle progression after hepatectomy by using adenoviral vectors (adv) expressing beta-galactosidase (beta-gal), a dominant-negative (Ras N17) or a do...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204690
更新日期:2001-08-30 00:00:00
abstract::Inhibition of telomerase activity by telomerase inhibitors induces a gradual loss of telomeres, and this in turn causes cancer cells to enter to a crisis stage. Here, we report the telomerase inhibitor telomestatin, which is known to stabilize G-quadruplex structures at 3' single-stranded telomeric overhangs (G-tails)...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209217
更新日期:2006-03-23 00:00:00
abstract::We have compared the DNase I hypersensitivity of the regulatory region of two estrogen-regulated genes, pS2 and cathepsin D in hormone-dependent and -independent breast carcinoma cell lines. This strategy allowed the identification of two important control regions, one in pS2 and the other in cathepsin D genes. In the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202317
更新日期:1999-01-14 00:00:00
abstract::In this age of targeted therapy, identification of molecular pathways that are deregulated in cancer will not only elucidate underlying tumorigenic mechanisms, but may also help to determine the classes of drugs that are used for treatment. In kidney cancer, a spectrum of histological subtypes exists that are characte...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210256
更新日期:2007-02-26 00:00:00
abstract::Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27. These pivotal epigenetic marks are altered in many cancers, including melanoma, as a result of EZH2 overexpression. Here, we show that the non-canonical-NF-kB pathway accounts for mo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.331
更新日期:2016-05-01 00:00:00
abstract::Matrix metalloproteinase-2 (MMP-2) has pivotal role in the degradation of extracellular matrix, and thereby enhances the invasive, proliferative and metastatic potential in cancer. Knockdown of MMP-2 using MMP-2 small interfering RNA (pM) in human glioma xenograft cell lines 4910 and 5310 decreased cell proliferation ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.52
更新日期:2013-01-17 00:00:00
abstract::O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inversely linked to hypermethylation of the CpG island in the promoter r...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207183
更新日期:2003-12-04 00:00:00
abstract::Chronic infection by hepatitis C virus (HCV) is a major risk factor for the onset and development of hepatocellular carcinoma (HCC), although the underlying mechanisms are unclear. The c-Myc oncogene contributes to the genesis of many types of cancers, including HCC, partly via the induction of genetic damage and the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.484
更新日期:2013-09-26 00:00:00
abstract::Topoisomerase IIalpha (topoIIalpha) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry because of insuffici...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.232
更新日期:2010-08-26 00:00:00
abstract::Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and caspase 8 upon death stimuli has been studied in detail, posttranslationa...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0323-z
更新日期:2018-09-01 00:00:00
abstract::Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking the ligand-binding domain, plays a key role in the development of castration-resistant prostate cancer (CRPC) and anti-androgen resistance. However, our understanding of the regulatory mechanisms of AR-V7-driven transcription ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0047-5
更新日期:2018-03-01 00:00:00