Abstract:
:As HTS technologies come of age, pharmaceutical companies are focusing increasingly on the quality of their screening collections. Storage conditions and their influence on compound stability and solubility are debated intensely. At Novartis, a strategy was developed that is different to most other companies: (1) compounds unsuitable for storage in solution are excluded by computational methods; (2) compounds are stored at 4 degrees C/20% relative humidity in a DMSO/water mixture to avoid freeze-thaw cycles and water uptake and to allow rapid plate replication; (3) resolubilisation of compounds at regular intervals.
journal_name
Comb Chem High Throughput Screenjournal_title
Combinatorial chemistry & high throughput screeningauthors
Schopfer U,Engeloch C,Stanek J,Girod M,Schuffenhauer A,Jacoby E,Acklin Pdoi
10.2174/1386207054867328subject
Has Abstractpub_date
2005-09-01 00:00:00pages
513-9issue
6eissn
1386-2073issn
1875-5402journal_volume
8pub_type
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