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The epigenetics of oral cancer.

Abstract：

:Whilst genetic alterations in oral cancer have long been documented, the appreciation of epigenetic changes is more recent. Epigenetic changes alter expression of tumour suppressor genes without changes in DNA sequence. Epigenetic mechanisms such as DNA methylation, histone methylation and deacetylation have been shown to silence key genes involved in cell proliferation, differentiation and genome integrity, and clearly have a central role in oral cancer. The pattern of hypermethylation in any individual tumour can now be accurately determined, which may find application in molecular staging. In addition, current trials are evaluating the safety and efficacy of agents affecting epigenetic changes in cancer patients which hold some therapeutic promise.

journal_name

Int J Oral Maxillofac Surg

journal_title

International journal of oral and maxillofacial surgery

authors

Shaw R

doi

10.1016/j.ijom.2005.06.014

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

101-8

issue

2

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(05)00223-7

journal_volume

35

pub_type

杂志文章,评审

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