Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid.

abstract：UNLABELLED:Cell movement is a fundamental process of normal cellular physiology and pathophysiology. Abnormal regulation of cell migration is a common denominator of many medical disorders, including cancer metastasis, autoimmune disease and inflammation. Increased interest in the targeting of cell migration and invasi...

journal_title：British journal of pharmacology

authors： Detchokul S,Frauman AG

更新日期：2014-12-01 00:00:00

abstract：:Biological nitrogen oxide signalling and stress is an area of extreme clinical, pharmacological, toxicological, biochemical and chemical research interest. The utility of nitric oxide and derived species as signalling agents is due to their novel and vast chemical interactions with a variety of biological targets. Her...

journal_title：British journal of pharmacology

authors： Heinrich TA,da Silva RS,Miranda KM,Switzer CH,Wink DA,Fukuto JM

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Heparin is known to possess a range of activities, other than effects on blood coagulation, many of which are anti-inflammatory. Effects with potential anti-inflammatory applications include the inhibition of elastase release from neutrophils, as well as the adhesion of these cells to vascular en...

journal_title：British journal of pharmacology

authors： Lever R,Lo WT,Faraidoun M,Amin V,Brown RA,Gallagher J,Page CP

更新日期：2007-07-01 00:00:00

abstract：:S-nitrosothiols have a number of potential clinical applications, among which their use as antithrombotic agents has been emphasized. This is largely because of their well-documented platelet inhibitory effects, which show a degree of platelet selectivity, although the mechanism of this remains undefined. Recent progr...

journal_title：British journal of pharmacology

authors： Gordge MP,Xiao F

更新日期：2010-04-01 00:00:00

abstract：:The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate in vitro was used for comparing atropine-like effects. Trazodone was found to have essentially no activity at the ...

journal_title：British journal of pharmacology

authors： Hyslop DK,Taylor DP

更新日期：1980-01-01 00:00:00

abstract：:1. The ability of the neuroprotective agent, lifarizine (RS-87476), to mitigate veratridine-, cyanide- and glutamate-induced toxicity in rat embryonic cerebrocortical neurones in primary culture has been compared with that of tetrodotoxin (TTX), nitrendipine, (+)-MK-801 and (-)-MK-801. Lactate dehydrogenase (LDH) rele...

journal_title：British journal of pharmacology

authors： May GR,Rowand WS,McCormack JG,Sheridan RD

更新日期：1995-04-01 00:00:00

abstract：:1. The effects of forskolin, a direct activator of adenylate cyclase and sodium nitroprusside, a direct activator of guanylate cyclase, were studied on rabbit isolated ear arteries preconstricted with 80 mM potassium. 2. Bolus injection of these two compounds resulted in vasodilatation. They had similar potencies in t...

journal_title：British journal of pharmacology

authors： Wood LM,Owen DA

更新日期：1989-03-01 00:00:00

abstract：:1. The aims of the present study were to determine whether long-term 5-hydroxytryptamine (5-HT) reuptake blockade and inhibition of type-A monoamine oxidase (MAO-A) lead to an enhancement of the electrically evoked release of tritum from guinea-pig brain slices preloaded with [3H]-5-HT, and to assess the sensitivity o...

journal_title：British journal of pharmacology

authors： Blier P,Bouchard C

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ajmaline is a widely used antiarrhythmic drug. Its action on voltage-gated ion channels in skeletal muscle is not well documented and we have here elucidated its effects on Na(+) and K(+) channels. EXPERIMENTAL APPROACH:Sodium (I(Na)) and potassium (I(K)) currents in amphibian skeletal muscle fi...

journal_title：British journal of pharmacology

authors： Friedrich O,V Wegner F,Wink M,Fink RH

更新日期：2007-05-01 00:00:00

abstract：:1. The purpose of the present study was to determine the myocardial cytoprotective efficacy of azapropazone (AZA) and its potential site of action on neutrophil infiltration into reperfused/ischaemic myocardium with or without in vivo activation of neutrophils in rabbits. 2. AZA, 100 mg kg-1, was administered i.v. 10 ...

journal_title：British journal of pharmacology

authors： Mousa SA,Brown R,Thoolen MJ,Smith RD

更新日期：1990-06-01 00:00:00

abstract：:1. Diabetic modifications of nicotinic receptor-operated noncontractile Ca2- mobilization observed in the presence of anticholinesterase were investigated by measuring Ca(2+)-aequorin luminescence in diaphragm muscles of mice with diabetes induced by injections of streptozotocin (150 mg kg-1, bolus i.v.) and alloxan (...

journal_title：British journal of pharmacology

authors： Kimura I,Tsuneki H,Dezaki K,Kimura M

更新日期：1995-11-01 00:00:00

abstract：:We examined whether a specific aminopeptidase P (APP) inhibitor, apstatin, increases vasodepressor responses to bradykinin in anaesthetized rats, and whether it would augment blood pressure responses further after treatment with the angiotensin-converting enzyme inhibitor (ACEi), lisinopril. Apstatin doubled the maxim...

journal_title：British journal of pharmacology

authors： Kitamura S,Carbini LA,Carretero OA,Simmons WH,Scicli AG

更新日期：1995-01-01 00:00:00

abstract：:1 The vasopressor response to prostaglandin F2 alpha (PGF2 alpha) and to ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)-prosta-5Z, 13E-dienoic acid) (U-46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was no...

journal_title：British journal of pharmacology

authors： Angerio AD,Fitzpatrick TM,Kot PA,Ramwell PW,Rose JC

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Emerging evidence indicates that hypertension is mediated by immune mechanisms. We hypothesized that exposure to Porphyromonas gingivalis antigens, commonly encountered in periodontal disease, can enhance immune activation in hypertension and exacerbate the elevation in BP, vascular inflammation ...

journal_title：British journal of pharmacology

authors： Czesnikiewicz-Guzik M,Nosalski R,Mikolajczyk TP,Vidler F,Dohnal T,Dembowska E,Graham D,Harrison DG,Guzik TJ

更新日期：2019-06-01 00:00:00

abstract：:1 The ventricular fibrillation threshold (VFT) was measured in the isolated heart of the rabbit perfused via the aorta with McEwen's solution at 37 degrees C by applying a single 10 ms pulse of current during the vulnerable period of late systole. The arrhythmia induced was either fibrillation or a rapid tachycardia. ...

journal_title：British journal of pharmacology

authors： Murnaghan MF

更新日期：1975-01-01 00:00:00

abstract：:1 The effects of a subconstrictor dose of histamine (9 x 10(-7) mol/l) on the responses of the isolated perfused ear artery of the rabbit to electrical stimulation (E.S.) and to exogenous noradrenaline (NA) were investigated.2 Both intraluminal (I/L) and extraluminal (E/L) histamine potentiated responses to E.S. and t...

journal_title：British journal of pharmacology

authors： Foldes A,Hall RC

更新日期：1979-11-01 00:00:00

abstract：:The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol hydrochloride (M320) on urine excretion by rats were investigated. Further studies, using rabbit isolated vas deferens, investigated its interactions with kappa-opiate receptors. The output of urine for a 2 h period after M320, administered subcutaneously to ...

journal_title：British journal of pharmacology

authors： Abrahams JM,Boura AL,Evans RG,Johnston CI,Olley JE

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Previous findings suggest that the growth and differentiation factor midkine (Mdk) is a negative regulator of osteoblast activity and bone formation, thereby raising the possibility that a specific Mdk antagonist might improve bone formation during fracture healing. EXPERIMENTAL APPROACH:In the ...

journal_title：British journal of pharmacology

authors： Haffner-Luntzer M,Heilmann A,Rapp AE,Roessler R,Schinke T,Amling M,Ignatius A,Liedert A

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease typically more common in males, implicating androgens in progression of both patients and mouse models. Androgen effects are mediated by androgen receptor which is highly expressed in spinal motor neurons and skeletal muscle...

journal_title：British journal of pharmacology

authors： McLeod VM,Lau CL,Chiam MDF,Rupasinghe TW,Roessner U,Djouma E,Boon WC,Turner BJ

更新日期：2019-07-01 00:00:00

abstract：:1. The effect on membrane currents of infection of mouse neuroblastoma NA cells with rabies virus was studied by using the whole-cell patch clamp technique. 2. Three types of membrane currents, namely voltage-dependent Na+ current (I(Na)), delayed rectifier K+ current (I(K-DR)) and inward rectifier K+ current (I(K-IR)...

journal_title：British journal of pharmacology

authors： Iwata M,Komori S,Unno T,Minamoto N,Ohashi H

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor agonists display a promising analgesic profile in preclinical studies. However, supraspinal N/OFQ produced hyperalgesia in rodents and such effects have not been addressed in primates. Thus, the aim of this study was to investigate the effects...

journal_title：British journal of pharmacology

authors： Ding H,Hayashida K,Suto T,Sukhtankar DD,Kimura M,Mendenhall V,Ko MC

更新日期：2015-07-01 00:00:00

abstract：:1. Sodium metabisulphite (MBS) can induce bronchoconstriction in patients with asthma. We investigated the effects of MBS aerosol on bronchial blood velocity (Vbr) and pulmonary resistance in intubated conscious sheep. 2. Bronchial blood velocity was measured by implanting a 20 MHz ultrasonic Doppler flow probe on the...

journal_title：British journal of pharmacology

authors： Nichol GM,Parsons GH,Chung KF

更新日期：1994-03-01 00:00:00

abstract：:Arterial stiffness progressively increases with aging and is an independent predictor of cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the time course of aging-related arterial stiffness and the associated CVD risk, which increases disproportionately in postmenopausal women. Th...

journal_title：British journal of pharmacology

authors： DuPont JJ,Kenney RM,Patel AR,Jaffe IZ

更新日期：2019-11-01 00:00:00

abstract：:1. The effects of intradermally injected prostaglandins (PGs) E(1), E(2), F(1alpha) and F(2alpha) have been examined in the rat and in man.2. PGE(1) and PGE(2) caused an increase in local vascular permeability in rat skin; their potency was comparable with that of other putative mediators of inflammation (histamine, b...

journal_title：British journal of pharmacology

authors： Crunkhorn P,Willis AL

更新日期：1971-01-01 00:00:00

abstract：:1 Acetylcholine-induced contractions of the isolated chronically denervated soleus muscle of the mouse consist of two phases, but both phases are equivalent to the contracture phase seen in vivo.2 Low [Ca(2+)](0) (0.5-1.5 mM) augmented peak tension, as well as the rate of relaxation, of the first phase, but inhibited ...

journal_title：British journal of pharmacology

authors： Hall MT,Maleque MA,Wadsworth RM

更新日期：1977-12-01 00:00:00

abstract：:Although previous reports have suggested that the sigma 1 (sigma(1)) receptor may be involved in pain sensation, its specific site of action has not been elucidated. The aim of present study was to determine the role of the spinal sigma(1) receptor in formalin-induced pain behavior, spinal cord Fos expression and phos...

journal_title：British journal of pharmacology

authors： Kim HW,Kwon YB,Roh DH,Yoon SY,Han HJ,Kim KW,Beitz AJ,Lee JH

更新日期：2006-06-01 00:00:00

abstract：:Although cyclosporin (CsA) is considered to be the best immunosuppressive molecule in transplantation, it has been suspected to alter mitochondrial respiration of various tissues. We evaluated the acute effect of CsA and its vehicle on maximal oxidative capacity (V(max)) of cardiac, soleus and gastrocnemius muscles of...

journal_title：British journal of pharmacology

authors： Sanchez H,Zoll J,Bigard X,Veksler V,Mettauer B,Lampert E,Lonsdorfer J,Ventura-Clapier R

更新日期：2001-07-01 00:00:00

abstract：:1. We showed earlier that NO inhibition caused a left-shift and augmented Emax of the concentration-response curve of AT1-mediated (angiotensin II)-induced vasoconstrictions (AII-VC) in the rat kidney. The 0.01-0.1 nM AII-VC unmasked by the potentiating effect of NO inhibition, were sensitive not only to AT1 (L158809)...

journal_title：British journal of pharmacology

authors： Muller C,Endlich K,Helwig JJ

更新日期：1998-07-01 00:00:00

abstract：:1 The venom of the green mamba, Dendroaspis angusticeps, was tested for effects on neuromuscular transmission and skeletal muscle contractility in isolated phrenic nerve-hemidiaphragm preparations of the rat and mouse, chick biventer cervicis muscle preparations and in aneural cultures of embryonic chick skeletal musc...

journal_title：British journal of pharmacology

authors： Barrett JC,Harvey AL

更新日期：1979-10-01 00:00:00

abstract：:1. To investigate the quantitative relationship between elevation in the intracellular Ca(2+) concentration ([Ca(2+)](i)) and nitric oxide (NO) production, the changes in [Ca(2+)](i) and NO production were determined in parallel, using fluorimetry of fura-2 and 2, 3-diaminonaphthalene, respectively, in endothelial cel...

journal_title：British journal of pharmacology

authors： Mizuno O,Kobayashi S,Hirano K,Nishimura J,Kubo C,Kanaide H

更新日期：2000-07-01 00:00:00