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Modification of membrane currents in mouse neuroblastoma cells following infection with rabies virus.

Abstract：

:1. The effect on membrane currents of infection of mouse neuroblastoma NA cells with rabies virus was studied by using the whole-cell patch clamp technique. 2. Three types of membrane currents, namely voltage-dependent Na+ current (I(Na)), delayed rectifier K+ current (I(K-DR)) and inward rectifier K+ current (I(K-IR)) were elicited in uninfected cells. 3. In cells 3 days after infection with the virus, no detectable change was observed in morphology and membrane capacitance, but I(Na) and I(K-IR) were significantly decreased in amplitude without any appreciable difference in the time course of current activation and inactivation. The voltage-dependence of I(Na) activation was significantly shifted in the positive direction along the voltage axis with a decreased slope. I(K-DR) remained almost unaltered after the viral infection. 4. The resting membrane potential, measured with a physiological K+ gradient across the cell membrane, was decreased (depolarized) after the viral infection. The depolarization was associated with the decreased amplitude of I(K-IR). 5. These results suggest that infection of mouse neuroblastoma NA cells with rabies virus causes reduction of functional expression of ion channels responsible for I(Na) and I(K-IR), and provide evidence for possible involvement of the change in membrane properties in the pathogenesis of rabies disease.

journal_name

Br J Pharmacol

journal_title

British journal of pharmacology

authors

Iwata M,Komori S,Unno T,Minamoto N,Ohashi H

doi

10.1038/sj.bjp.0702473

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

1691-8

issue

8

eissn

0007-1188

issn

1476-5381

journal_volume

126

pub_type

杂志文章

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