Healing following tooth extraction in cyclosporine-fed rats.

Abstract:

:Healing after tooth extraction was studied in rats treated with cyclosporine-A (CSA) for four weeks. Sixty male Sprague-Dawley rats were assigned to one of three groups of 20 rats each. The maxillary right molars were extracted from two groups; the third group served as a non-extraction control. The non-extraction group and one extraction group (vehicle control) received the solvent mineral oil daily, and the other extraction group received 15 mg/kg CSA in mineral oil. Five rats from each group were killed 5, 10, 14 and 28 days after extraction and samples analyzed histologically. On days 5 and 10, bone volume was significantly lower and marrow volume significantly higher in both extraction groups than in the non-extraction group. The fractional-formation surfaces were significantly lower in the extraction groups than in the non-extraction group on day 5 only. Osteoid volume was significantly higher in the extraction vehicle control group than in the other two groups on days 10 and 14; however, the osteoid volume was higher in the CSA group than in the other two groups on day 28. On days 14 and 28, bone volume was lower and marrow volume higher in the CSA group than in the extraction vehicle control and non-extraction groups. On day 28, bony surface areas were significantly greater in the CSA group than in the extraction vehicle control and non-extraction groups. Soft-tissue evaluation showed significantly greater epithelial areas, connective tissue areas and total tissue areas in the CSA group than in the extraction vehicle control group on day 28, but not on day 14. These data suggest that CSA may influence healing of both the gingival tissue and the alveolar bony sockets in the tooth-extraction wound. Further detailed study is needed to identify the mechanisms responsible.

authors

Gau CH,Hsieh YD,Shen EC,Lee S,Chiang CY,Fu E

doi

10.1016/j.ijom.2005.02.010

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

782-8

issue

7

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(05)00068-8

journal_volume

34

pub_type

杂志文章
  • Topical combined application of dexamethasone, vitamin C, and β-sodium glycerophosphate for healing the extraction socket in rabbits.

    abstract::An osteogenic inducer (OI) consisting of dexamethasone, vitamin C, and β-sodium glycerophosphate has the capacity to induce bone formation in vitro. The aim of this study was to assess the efficacy of the application of this OI on extraction socket healing. The bilateral first mandibular premolars were extracted from ...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2015.06.011

    authors: Chen J,He Y,Shan C,Pan Q,Li M,Xia D

    更新日期:2015-10-01 00:00:00

  • An infected congenital commissural lip fistula. Report of a case.

    abstract::A case of infected congenital commissural lip fistula is presented. It appeared as a cheek swelling associated with inflammation due to infection. This case was treated with antibiotics and surgical drainage through the fistula. Our experience suggests that the possibility of infection of the fistula should be conside...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/s0901-5027(05)80135-3

    authors: Ishimaru J,Toida M,Handa Y,Tatematsu N,Okuda T

    更新日期:1990-06-01 00:00:00

  • Histologic findings and related diagnostic methods in condylar hyperactivity.

    abstract::Condylar hyperactivity (CH) is a rare condition that entails a progressive deviation and deformation of the mandible. There is no consensus regarding characteristic histopathological features or a standardized diagnostic process; thus, histopathological analysis of the condyle cannot confirm or exclude an active CH af...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijom.2020.07.001

    authors: Espinosa S,Covarrubias E,Díaz R,Díaz KT,Cafferata EA

    更新日期:2021-01-01 00:00:00

  • Clinical comparison of patients with osteonecrosis of the jaws, with and without a history of bisphosphonates administration.

    abstract::This retrospective study aimed to evaluate the role of bisphosphonates in jaw osteomyelitis. 29 patients were included: 18 had been treated with bisphosphonates (12 with multiple myelomas, 3 with breast carcinomas, 2 with prostate carcinomas, and 1 with osteoporosis). Of 11 control patients, 2 had breast carcinomas, 2...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2010.04.054

    authors: Kos M,Brusco D,Kuebler J,Engelke W

    更新日期:2010-11-01 00:00:00

  • Ossification of vascular pedicle in fibular free flaps: a report of four cases.

    abstract::The fibular free flap is the most widely used flap for jaw reconstruction. Flap contouring requires removal of bone excess in the proximal segment by a subperiosteal dissection, preserving vascular connections between the pedicle and the bone and leaving well vascularized periosteum attached to the vascular pedicle. A...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2008.01.023

    authors: Autelitano L,Colletti G,Bazzacchi R,Biglioli F

    更新日期:2008-07-01 00:00:00

  • Le Fort I distraction osteogenesis of the edentulous maxilla.

    abstract::Rehabilitation of the edentulous patient with atrophic ridges is a problem especially when compounded with a severe prognathic inter-arch relationship. It is difficult to rehabilitate these patients prosthetically without correction of the malrelation of the jaws. The established surgical techniques for correcting com...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2010.09.024

    authors: Malik NA,Kumar VV,Bora P

    更新日期:2011-04-01 00:00:00

  • Immediate loading of implants inserted in edentulous arches using multiple mucosa-supported stereolithographic surgical templates: a 10-year prospective cohort study.

    abstract::The purpose of this prospective study was to evaluate survival and marginal bone loss at 10-year follow-up of implants inserted in completely edentulous arches and immediately loaded using multiple mucosa-supported stereolithographic surgical templates. The influence on marginal bone loss of the following variables wa...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2015.12.001

    authors: Cassetta M

    更新日期:2016-04-01 00:00:00

  • Assessing the influence of chin prominence on perceived attractiveness in the orthognathic patient, clinician and layperson.

    abstract::The purpose of this investigation was to undertake an objective and quantitative evaluation of how the degree of chin prominence influences perceived attractiveness. The chin prominence of an idealized profile image was altered in 2 mm increments from -24 to 12 mm, in order to represent retrusion and protrusion of the...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2012.01.012

    authors: Naini FB,Donaldson AN,McDonald F,Cobourne MT

    更新日期:2012-07-01 00:00:00

  • Solitary fibrous tumour of the tongue: a case report with immunohistochemical studies.

    abstract::The solitary fibrous tumour (SFT), also known as a localized fibrous mesothelioma, is a neoplasm characterized by the proliferation of capillaries surrounded by masses of round or spindle-shaped cells. SFT has been discovered in many locations, however, it is extremely rare for SFT to be found in the intraoral region....

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1054/ijom.2001.0201

    authors: Yamashita Y,Satoh T,Goto M

    更新日期:2002-12-01 00:00:00

  • Ridge augmentation in an organ transplant patient.

    abstract::With the continuing progress in medicine, the number of successful organ transplantations has continued to increase, a fact that also concerns dentists and implantologists. Implantology after organ transplantation remains controversial due to the patient's immunocompromised situation and the corresponding risk of infe...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2015.11.002

    authors: Dalla Torre D,Burtscher D

    更新日期:2016-05-01 00:00:00

  • Computed tomographic analysis of the position and course of the mandibular canal: relevance to the sagittal split ramus osteotomy.

    abstract::The aim of this study was to investigate the position and course of the mandibular canal through the mandibular ramus using computed tomographic (CT) imaging and to relate the findings to performing sagittal split ramus osteotomies. The mandibles of 35 patients with skeletal Class III prognathism with symmetry (12 mal...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2004.06.001

    authors: Tsuji Y,Muto T,Kawakami J,Takeda S

    更新日期:2005-05-01 00:00:00

  • Changes in border movement of the mandible in skeletal Class III before and after orthognathic surgery.

    abstract::The purpose of this study was to examine the changes in border movement of the mandible before and after mandibular ramus osteotomy in patients with prognathism. The subjects were 73 patients with mandibular prognathism who underwent sagittal split ramus osteotomy (SSRO) with and without Le Fort I osteotomy. Border mo...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2013.07.740

    authors: Ueki K,Marukawa K,Moroi A,Sotobori M,Ishihara Y,Iguchi R,Kosaka A,Nakano Y,Higuchi M,Nakazawa R

    更新日期:2014-02-01 00:00:00

  • Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people.

    abstract::The increasing incidence of oral squamous cell carcinoma (SCC) especially among younger people has been observed in many parts of the world. The objective of this study was to delineate the profile of patients with oral SCC with an emphasis on younger people in northern Thailand between 1991-2000. The medical records ...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1054/ijom.2003.0503

    authors: Iamaroon A,Pattanaporn K,Pongsiriwet S,Wanachantararak S,Prapayasatok S,Jittidecharaks S,Chitapanarux I,Lorvidhaya V

    更新日期:2004-01-01 00:00:00

  • Oculo-facio-cardio-dental syndrome in a mother and daughter.

    abstract::Oculo-facio-cardio-dental (OFCD) syndrome is a rare X-linked dominant syndrome characterized by canine teeth with extremely large roots (radiculomegaly), congenital cataract, dysmorphic facial features and congenital heart disease. A case of mother-daughter vertical transmission of OFCD is reported. Dental findings we...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2006.05.001

    authors: McGovern E,Al-Mudaffer M,McMahon C,Brosnahan D,Fleming P,Reardon W

    更新日期:2006-11-01 00:00:00

  • Oral health-related quality of life following orthognathic surgery for class III correction its relationship with cephalometric changes.

    abstract::The aim of this study was to investigate the cephalometric changes following orthognathic surgery for class III correction and to compare these with the changes in patient perceptions of their oral health-related quality of life (OHRQoL). Twenty-nine severe skeletal class III patients, who were candidates for bilatera...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2019.03.899

    authors: Geramy A,Mazaheri Nazarifar A,Saffar Shahroudi A,Sheikhzadeh S

    更新日期:2019-11-01 00:00:00

  • Treatment of chronic mandibular dislocations using a new miniplate.

    abstract::Temporomandibular joint (TMJ) dislocation is defined as an excessive forward movement of the condyle beyond the articular eminence with complete separation of the articular surfaces and fixation in that position. The aim of this study was to describe a modified miniplate designed for treating chronic mandibular disloc...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2011.04.019

    authors: Cavalcanti JR,Vasconcelos BC,Porto GG,Carneiro SC,do Nascimento MM

    更新日期:2011-12-01 00:00:00

  • Intralesional infiltration of corticosteroids in the treatment of localised langerhans' cell histiocytosis of the mandible Report of known cases and three new cases.

    abstract::Langerhans' cell histiocytosis (LCH) can involve virtually any site and organ of the body, either as an isolated lesion or as a widespread systemic disease. Bone can be involved as a part of generalised disease or as a separate entity, formerly known as eosinophilic granuloma. The clinical cause of localised LCH (LLCH...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijom.2004.10.020

    authors: Putters TF,de Visscher JG,van Veen A,Spijkervet FK

    更新日期:2005-07-01 00:00:00

  • Burnout syndrome in oral and maxillofacial surgeons: a critical analysis.

    abstract::The aim of this study was to determine the prevalence of burnout syndrome among Brazilian oral and maxillofacial surgeons and its relationship with socio-demographic, clinical, and habit variables. The sample of this study comprised 116 surgeons. The syndrome was quantified using the Maslach Burnout Inventory (General...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2013.10.025

    authors: Porto GG,Carneiro SC,Vasconcelos BC,Nascimento MM,Leal JL

    更新日期:2014-07-01 00:00:00

  • A clinical study of the craniofacial features in Apert syndrome.

    abstract::A clinical study of the craniofacial features in Apert syndrome is based on our experience with 136 cases. Characteristics included hyperacrobrachycephaly, steep wide forehead, flat occiput, common craniofacial asymmetry, ocular hypertelorism and proptosis, downslanting palpebral fissures, divergent upgaze and esotrop...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/s0901-5027(96)80011-7

    authors: Cohen MM Jr,Kreiborg S

    更新日期:1996-02-01 00:00:00

  • The opinions of 100 international experts on temporomandibular joint surgery. A postal questionnaire.

    abstract::A postal survey of the views of 100 international experts in temporomandibular joint surgery was performed. Generally, there was a considerable degree of consensus on definitions, diagnosis, and broad treatment principles. However, specific surgical techniques for particular stages of internal derangement and osteoart...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/s0901-5027(05)80804-5

    authors: Goss AN

    更新日期:1993-04-01 00:00:00

  • Treatment of recurrent mandibular dislocation, Part I: Leclerc blocking procedure.

    abstract::Nine patients with recurrent mandibular dislocation, who underwent the blocking procedure of Leclerc and Girard, as modified by Gosserez and Dautrey, are presented. The follow-up period range from 2.5 to 5 years. An axiographic study revealed significant postoperative limitation of translation of the condyle when open...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/s0901-5027(05)80634-4

    authors: Undt G,Kermer C,Piehslinger E,Rasse M

    更新日期:1997-04-01 00:00:00

  • A comparison of postoperative hypoesthesia between two types of sagittal split ramus osteotomy and intraoral vertical ramus osteotomy, using the trigeminal somatosensory-evoked potential method.

    abstract::The purpose of this study was to evaluate hypoesthesia of the lower lip using trigeminal somatosensory-evoked potential following 2 types of sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO). There were 30 patients with mandibular prognathism, with and without asymmetry, who were divi...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ijom.2006.09.016

    authors: Takazakura D,Ueki K,Nakagawa K,Marukawa K,Shimada M,Shamiul A,Yamamoto E

    更新日期:2007-01-01 00:00:00

  • Blood loss and endocrine responses in hypotensive anaesthesia with sodium nitroprusside and nitroglycerin for mandibular osteotomy.

    abstract::The purpose of this study was to determine the differences in endocrine responses, blood loss and arterial blood gas profiles between patients subjected to hypotensive anaesthesia or normotensive anaesthesia and those between patients given sodium nitroprusside (SNP) or nitroglycerin (NTG) as the hypotensive agent. 36...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ijom.2009.06.005

    authors: Yoshikawa F,Kohase H,Umino M,Fukayama H

    更新日期:2009-11-01 00:00:00

  • Auto-fluorescence of the bone and its use for delineation of bone necrosis.

    abstract::Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication of long-term bisphosphonate treatment. Currently, the drawback in the surgical management of BRONJ is the difficulty distinguishing between viable and necrotic bone. Intraoperative bone fluorescence induced by tetracyclines has been ...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2014.07.017

    authors: Ristow O,Pautke C

    更新日期:2014-11-01 00:00:00

  • Where can I learn how to place dental implants? Perspectives from Scandinavia and Canada.

    abstract::An overview is presented of the educational opportunities that exist for dentists in Canada and in the five Nordic countries who wish to learn how to implement implant dentistry in clinical practice. This theme is discussed in the context of the demographic and educational realities in these countries. Data related to...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2007.12.009

    authors: Jokstad A

    更新日期:2008-07-01 00:00:00

  • Psychogenic coma after dental surgery under general anaesthesia.

    abstract::Delayed awakening after general anaesthesia due to psychogenic coma is a phenomenon that rarely presents to the oral and maxillofacial surgeon. A case of psychogenic coma following general anaesthesia for dental extractions is presented here. It is recommended that patients at risk of conversion disorder should be cou...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2018.06.012

    authors: Yong CW,Ng WH,Yap SH,D'Souza J,Ow AT

    更新日期:2018-12-01 00:00:00

  • Emergency removal of a grinding wheel embedded in the midface via modified Le Fort I osteotomy.

    abstract::Le Fort I osteotomy is commonly used to rectify craniofacial deformity in orthognathic surgery and it can be used in approaching a cranial base lesion. This technique has not been well documented in craniofacial penetrating trauma. This article describes a case of midface penetrating injury caused by a grinding wheel....

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2010.10.012

    authors: Jiang WH,Wang XD,Shen GF

    更新日期:2011-04-01 00:00:00

  • Randomized double-blind clinical trial evaluation of bone healing after third molar surgery with the use of leukocyte- and platelet-rich fibrin.

    abstract::The objective of this study was to evaluate the use of leukocyte- and platelet-rich fibrin (L-PRF) in bone healing after mandibular third molar extraction. In this prospective, double-blind, split-mouth study, 34 extractions were performed. On one side, the socket was sutured primarily (control side); on the other sid...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ijom.2019.01.020

    authors: Ritto FG,Pimentel T,Canellas JVS,Junger B,Cruz M,Medeiros PJ

    更新日期:2019-08-01 00:00:00

  • Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases.

    abstract::From March 1991 to February 2001, 80 cases of minor salivary gland tumours were diagnosed in the Department of Oral and Maxillofacial Surgery at the University of Maryland at Baltimore (Baltimore, MD, USA). Data extracted from a retrospective chart review included age, sex, symptoms, site, histological diagnosis. trea...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1054/ijom.2002.0223

    authors: Jansisyanont P,Blanchaert RH Jr,Ord RA

    更新日期:2002-06-01 00:00:00

  • Screening for maternal coeliac disease as a potential risk factor for orofacial clefts--a pilot study.

    abstract::There is increasing evidence that dietary folic acid deficiency in utero may increase the risk of developing the 'cleft lip with or without cleft palate' (CL±P) variant of orofacial cleft. Coeliac disease is a common cause of folic acid malabsorption, and in the majority of cases remains undiagnosed. This pilot study ...

    journal_title:International journal of oral and maxillofacial surgery

    pub_type: 杂志文章

    doi:10.1016/j.ijom.2013.03.021

    authors: Reddy SG,Reddy RR,Vaidhyanathan A,Markus A,Snook J

    更新日期:2013-11-01 00:00:00