Abstract:
:Few studies have investigated the frequency of hereditary non-polyposis colorectal cancer (HNPCC) in patients with colorectal cancer (CRC), and these have shown marked geographic variations. The aim of this study was to estimate the frequency of HNPCC in a cohort of Uruguayan CRC patients. We included all patients operated consecutively for CRC in the Hospital Central de las Fuerzas Armadas (Uruguay) between 1987 and 2003. Cases were classified into three groups: (i) those fulfilling Amsterdam criteria; (ii) those not fulfilling Amsterdam criteria but considered as a population at increased risk of cancer; and (iii) sporadic CRC. Genetic analysis to detect point mutations in hMLH/hMSH2/hMSH6 genes was performed in group 1 patients. Cases not showing mutations were tested by multiplex ligation-dependent probe amplification. Among 461 patients, group 1 represented 2.6%, group 2 represented 5.6%, and sporadic cases 91.8%. hMLH1/hMSH2/hMSH6 mutations were found in 25% of cases classified as HNPCC (two in hMLH1 and one in hMSH2). No mutations were detected in hMSH6 gene. The proportion of CRC patients that fulfilled Amsterdam criteria agrees with other reports. However, the percentage of HNPCC cases with identified mutations (25%) may be lower than that reported from other populations. This may reflect, among other possible causes, a different genetic profile in the Uruguayan population.
journal_name
Clin Genetjournal_title
Clinical geneticsauthors
Sarroca C,Valle AD,Fresco R,Renkonen E,Peltömaki P,Lynch Hdoi
10.1111/j.1399-0004.2005.00458.xsubject
Has Abstractpub_date
2005-07-01 00:00:00pages
80-7issue
1eissn
0009-9163issn
1399-0004pii
CGE458journal_volume
68pub_type
杂志文章abstract::Lynch syndrome is caused by germline mutations in the mismatch repair genes MLH1, MSH2, MSH6 or PMS2. The novel MSH2 c.[2635-3T>C; 2635-5C>T] mutation was identified in 4 Lynch families, cosegregating with the disease. This mutation, located in intron 15, was predicted to alter the correct mRNA processing by in silico...
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journal_title:Clinical genetics
pub_type: 杂志文章
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doi:10.1111/j.1399-0004.1978.tb02108.x
更新日期:1978-08-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
doi:10.1111/j.1399-0004.1984.tb01061.x
更新日期:1984-10-01 00:00:00
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journal_title:Clinical genetics
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journal_title:Clinical genetics
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doi:10.1111/j.1399-0004.1978.tb02133.x
更新日期:1978-10-01 00:00:00
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更新日期:1983-04-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
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更新日期:1989-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Clinical genetics
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更新日期:1979-11-01 00:00:00