Molecular psychiatry meeting, February 2004, Park City, Utah.

abstract：:A 50-year-old man presented with worsening, virtually lifelong, chorea and progressive behavioural disturbance, involving disinhibition and hoarding, over 10 years. Clinical assessment revealed chorea, dysarthria, areflexia, an inappropriately jovial, impulsive manner and neuropsychological evidence of frontosubcortic...

journal_title：Psychiatric genetics

authors： Zeman A,Daniels G,Tilley L,Dunn M,Toplis L,Bullock T,Poole J,Blackwood D

更新日期：2005-12-01 00:00:00

abstract：:Evidence for a dysfunction of the N-methyl-D-aspartate (NMDA) type of ionotropic glutamate receptors in schizophrenic patients, comes from neurochemical and clinical pharmacologic data. Therefore, the NMDAR1 gene can be regarded as an interesting candidate gene for schizophrenia. Several groups have tried to identify ...

journal_title：Psychiatric genetics

authors： Paus S,Rietschel M,Schulze TG,Ohlraun S,Diaconu CC,Van Den Bogaert A,Maier W,Propping P,Cichon S,Nöthen MM

更新日期：2004-12-01 00:00:00

abstract：:Dysregulation of the immune system has been suggested to play a role in the complex etiology of obsessive-compulsive disorder. In this context, tumor necrosis factor-alpha is considered an interesting candidate for genetic studies as overproduction of tumor necrosis factor-alpha, which may be genetically modulated, ca...

journal_title：Psychiatric genetics

authors： Zai G,Arnold PD,Burroughs E,Richter MA,Kennedy JL

更新日期：2006-02-01 00:00:00

abstract：:A polymorphic 44-nucleotide insertion/deletion in the promoter region of the serotonin transporter gene (5-HTTLPR) has been shown to affect the level of expression of the serotonin transporter protein. An association between anxiety-related behavioural traits and the short form of the 5-HTTLPR has been reported. We de...

journal_title：Psychiatric genetics

authors： Ricketts MH,Hamer RM,Sage JI,Manowitz P,Feng F,Menza MA

更新日期：1998-07-01 00:00:00

abstract：:Since 1969, several classical linkage studies suggested an X-chromosome locus for bipolar affective disorder. However, methods using highly polymorphic DNA markers have provided conflicting evidence for linkage, and an X-chromosomal locus for bipolar disorder remains controversial. More recently, Pekkarinen et al. (19...

journal_title：Psychiatric genetics

authors： Vallada HP,Vasques L,Curtis D,Zatz M,Kirov G,Lauriano V,Gentil V,Murray RM,McGuffin P,Owen M,Gill M,Craddock N,Collier DA

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To examine the heritabilities of symptoms of posttraumatic stress disorder (PTSD), anxiety, depression, and the shared genetic component of these symptoms among family members exposed to the 1988 Spitak earthquake in Armenia. METHODS:Two hundred members of 12 multigenerational families exposed to the Spitak ...

journal_title：Psychiatric genetics

authors： Goenjian AK,Noble EP,Walling DP,Goenjian HA,Karayan IS,Ritchie T,Bailey JN

更新日期：2008-12-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) metabolizes catecholamines such as dopamines, noradrenaline and adrenaline. It exists as common high and low activity alleles in the population (determined by a valine 158 methionine polymorphisms), and high red blood cell activity of COMT has previously been associated with schizop...

journal_title：Psychiatric genetics

authors： Kunugi H,Vallada HP,Sham PC,Hoda F,Arranz MJ,Li T,Nanko S,Murray RM,McGuffin P,Owen M,Gill M,Collier DA

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:The role of the human serotonin transporter protein (5-HTT) gene in psychiatric disorders suggests that its variation may influence the comorbidity pattern and the heterogeneity of alcoholism. The aim of the present study is to verify possible associations between the 5-HTTLPR control region polymorphism with...

journal_title：Psychiatric genetics

authors： Marques FZ,Hutz MH,Bau CH

更新日期：2006-06-01 00:00:00

abstract：:Animal and human studies have implicated oxytocin in affiliative and prosocial behaviors. We tested whether genetic variation in the oxytocin receptor (OXTR) gene is associated with conduct disorder (CD). Utilizing a family-based sample of adolescent probands recruited from an adolescent substance abuse treatment prog...

journal_title：Psychiatric genetics

authors： Sakai JT,Crowley TJ,Stallings MC,McQueen M,Hewitt JK,Hopfer C,Hoft NR,Ehringer MA

更新日期：2012-04-01 00:00:00

abstract：:Developmental dyslexia (DD) is a neurobiological disorder featured by reading disabilities. In recent years, genome-wide approaches provided new perspectives to discover novel candidate genes of DD. In a previous study, rs9313548 located downstream of FGF18 showed borderline genome-wide significant association with DD...

journal_title：Psychiatric genetics

authors： Chen H,Zhou Y,Ge Z,Li Q,Sun Q,Zheng L,Lv H,Tan LH,Sun Y

更新日期：2018-02-01 00:00:00

abstract：:The trichorhinophalangeal syndrome is a rare genetic disorder with a classical clinical triad of sparse hair, bulbous nose, and short digits. There are three known phenotypes, and the type II with exostoses in long bones is known as Langer-Giedion syndrome. Here, we describe a 28-year-old Sri Lankan male with Langer-G...

journal_title：Psychiatric genetics

authors： Chandradasa M,Williams S

更新日期：2018-06-01 00:00:00

abstract：:Basal serum thyroid-stimulating hormone (TSH) levels may predict antidepressant efficacy in patients with major depressive episodes (MDE), but data are inconsistent. As the SS genotype of the 5-HTTLPR polymorphism has been associated with a lower antidepressant efficacy in women with MDE, we aimed at assessing the rel...

journal_title：Psychiatric genetics

authors： Gressier F,Trabado S,Verstuyft C,Bouaziz E,Hardy P,Fève B,Becquemont L,Corruble E

更新日期：2011-10-01 00:00:00

abstract：:Disturbed glutamatergic neurotransmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder, with the N-methy-D-aspartate receptors being in the focus of research. The NR1 subunit, which is encoded by the gene GRIN1, plays a key role in the functionality of N-methy-D-aspartate receptors. We...

journal_title：Psychiatric genetics

authors： Georgi A,Jamra RA,Schumacher J,Becker T,Schmael C,Deschner M,Höfels S,Wulff M,Schwarz M,Klopp N,Illig T,Propping P,Cichon S,Nöthen MM,Rietschel M,Schulze TG

更新日期：2006-10-01 00:00:00

abstract：:A new structural polymorphism (Ser311/Cys311) in the dopamine D2 receptor (DRD2) gene has recently been reported to be associated with schizophrenia, particularly in patients with a positive family history of schizophrenia (Arinimi et al., 1994). However these findings remain controversial (Asherson et al., 1994; Nank...

journal_title：Psychiatric genetics

authors： Laurent C,Bodeau-Péan S,Campion D,d'Amato T,Jay M,Dollfus S,Thibault F,Petit M,Samolyk D,Martinez M

更新日期：1994-01-01 00:00:00

abstract：:The purpose of the present study was to investigate the association between the monocyte chemoattractant protein-1 (MCP-1) promoter -2518 polymorphism and schizophrenia. One hundred and twenty-three schizophrenic inpatients and 114 healthy controls participated in this study. Genotyping was performed by polymerase cha...

journal_title：Psychiatric genetics

authors： Pae CU,Chung KI,Kim JJ,Yu HS,Lee CU,Lee SJ,Lee C,Jun TY,Serretti A,Paik IH

更新日期：2004-06-01 00:00:00

abstract：:There is evidence for a genetic contribution to attention-deficit hyperactivity disorder (ADHD), although no candidate genes have attained genome-wide significance to date. Given that the noradrenergic system has been implicated in ADHD, the gene for the α2-adrenergic receptor (ADRA2A) has been hypothesized to contrib...

journal_title：Psychiatric genetics

authors： Shiffrin ND,Gruber J,Glatt SJ,Faraone SV

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:The National Institute of Mental Health's effort to rectify the underrepresentation of American Blacks in the genetic studies of psychiatric disorders has met with mixed success. This study was designed to understand some of the barriers to recruitment. METHODS:Men and women, who were of Black, White or Hisp...

journal_title：Psychiatric genetics

authors： Murphy EJ,Wickramaratne P,Weissman MM

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Recent research has shown that loneliness, a common problem in adolescence, may have a genetic basis. The evidence, though, was limited mostly to serotonin-related and dopamine-related genes. In the present study, we focused on the oxytocin receptor gene (OXTR). METHODS:Associations were examined in a longi...

journal_title：Psychiatric genetics

authors： van Roekel E,Verhagen M,Engels RC,Goossens L,Scholte RH

更新日期：2013-10-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of the 5-HTTLPR and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms on self-reported Big Five personality traits and their facets in a population representative sample of adolescents. The sample consisted of both cohorts of the Estonian Children ...

journal_title：Psychiatric genetics

authors： Hiio K,Merenäkk L,Nordquist N,Parik J,Oreland L,Veidebaum T,Harro J

更新日期：2011-10-01 00:00:00

abstract：:The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the central nervous system. Brain-derived neurotrophic factor biosynthesis and secretion are chrono-topically regulated processes at the cellula...

journal_title：Psychiatric genetics

authors： Di Carlo P,Punzi G,Ursini G

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Recent biopsychological research on stress-related psychopathology shows promising evidence for the 5-hydroxytryptamine (5-HT) transporter linked polymorphic region (5-HTTLPR) genotype by life event interaction on depression. Yet, there appears to be variability in replicating such findings. From leading c...

journal_title：Psychiatric genetics

authors： Markus CR

更新日期：2013-06-01 00:00:00

abstract：:A number of genes underlie the molecular bases of intelligence. Among these is probably CALL, a novel member of the L1 gene family of neural cell adhesion molecules. By using the single strand conformation polymorphism (SSCP) protocol, we screened the regions of the CALL gene corresponding to the 5' and 3' untranslate...

journal_title：Psychiatric genetics

authors： Angeloni D,Wei MH,Lerman MI

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVES:The genetic basis of schizophrenia is obscure. In an XX male patient with schizophrenia we previously showed that one X;Y translocation breakpoint was in pseudoautosomal region 1 (PAR1) with the effect that the proximal segment of PAR1 from the PAR1 boundary to acetylserotonin N-methyl transferase (ASMT) dis...

journal_title：Psychiatric genetics

authors： Ross NL,Mavrogiannis LA,Sargent CA,Knight SJ,Wadekar R,DeLisi LE,Crow TJ

更新日期：2003-06-01 00:00:00

abstract：:We report here linkage data on two families with multiple cases of schizophrenia originating from the genetically isolated population of Finland. We analyzed chromosomal DNA regions containing relevant candidate genes for schizophrenia and chromosomal regions which have been among the most widely studied in schizophre...

journal_title：Psychiatric genetics

authors： Hovatta I,Seppälä J,Pekkarinen P,Tanskanen A,Lönnqvist J,Peltonen L

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:Susceptibility to heroin dependence is strongly influenced by genetic factors with heritability estimates as high as 0.7. A number of genes, as well as environmental factors, are likely to contribute to its etiology. Not all individuals who have ever tried heroin at some stage during their lifetime become de...

journal_title：Psychiatric genetics

authors： Eirich A,Biermann T,Müller CP,Kornhuber J,Benyamin B,Hulse GK,Wildenauer DB,Schwab SG

更新日期：2019-02-01 00:00:00

abstract：:Genetic research of cocaine abuse has been relatively limited among the African-American population. Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American ...

journal_title：Psychiatric genetics

authors： Patkar AA,Berrettini WH,Hoehe M,Hill KP,Gottheil E,Thornton CC,Weinstein SP

更新日期：2002-09-01 00:00:00

abstract：:We have undertaken a search for polymorphic sequence variation within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2 (DISC1 and DISC2), which are both novel genes that span a translocation breakpoint strongly associated with schizophrenia and related psychoses in a large Scottish family. A scan of the c...

journal_title：Psychiatric genetics

authors： Devon RS,Anderson S,Teague PW,Burgess P,Kipari TM,Semple CA,Millar JK,Muir WJ,Murray V,Pelosi AJ,Blackwood DH,Porteous DJ

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:Postpartum depression (PPD) is an under diagnosed and under treated mood disorder, with negative impact on both the mother and the infant's health. The aim of this study is to examine whether genetic variations in the monoaminergic neurotransmitter system, together with environmental stressors, contribute to ...

journal_title：Psychiatric genetics

authors： Comasco E,Sylvén SM,Papadopoulos FC,Sundström-Poromaa I,Oreland L,Skalkidou A

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:The dopamine D4 receptor (DRD4) is a candidate gene for increasing genetic susceptibility to schizophrenia. A recent study found that a -521C>T promoter base pair change affects transcriptional regulation of the DRD4 gene. The present study was designed to investigate the role of both the -521C>T single nucle...

journal_title：Psychiatric genetics

authors： Lung FW,Chen N,Shu BC

更新日期：2006-08-01 00:00:00

abstract：:Chromosome 12q is a region of interest for the genetics of bipolar affective disorder because of reports of apparent cosegregation between this disorder and Darier's disease in a small number of families. Findings from a recent linkage study suggest that this chromosomal region may contain a susceptibility gene for bi...

journal_title：Psychiatric genetics

authors： Dawson E,Gill M,Curtis D,Castle D,Hunt N,Murray R,Powell J

更新日期：1995-01-01 00:00:00