Abstract：
BACKGROUND:Oral loading with the delayed release formulation of divalproex sodium is widely used for the treatment of patients with acute mania and produces rapid attainment of therapeutic serum levels. Recently, an extended release formulation of divalproex sodium (divalproex ER) was approved for treatment of migraine headaches. This formulation may be a useful treatment option for patients with acute mania. METHOD:A retrospective review of medical records was conducted on 14 inpatients with acute mania whose treatment included initiation of divalproex ER at a dose of 30 mg kg(-1) day(-1) in a single dose. Doses, serum levels and side effects associated with this treatment were recorded from the medical records of these patients. RESULTS:The average dose of divalproex ER was 2034 mg day(-1) (range, 1500-3000 mg day(-1)). Two of the 14 patients (14%) had documented side effects, none of which were severe. The average level obtained on day 3 after initiation of divalproex ER treatment was 93.2 mug ml(-1) (range, 47-136 mug ml(-1)), and in all but three patients valproate levels at this time point were within the therapeutic range of 50-125 mug ml(-1). In no case was divalproex ER discontinued due to a perceived lack of efficacy. CONCLUSION:The results suggest that divalproex ER can be safely administered by oral loading in inpatients with acute mania and that using a standard loading protocol can result in therapeutic serum levels in most patients in 3 days or less.
journal_name
Gen Hosp Psychiatryjournal_title
General hospital psychiatryauthors
Miller BP,Perry W,Moutier CY,Robinson SK,Feifel Ddoi
10.1016/j.genhosppsych.2005.02.001subject
Has Abstractpub_date
2005-05-01 00:00:00pages
218-21issue
3eissn
0163-8343issn
1873-7714pii
S0163-8343(05)00019-8journal_volume
27pub_type
杂志文章abstract：:Several predictors of the course of depression and generalized anxiety have been identified. Whether these predictors provide a solid basis for primary care physicians (PCPs) to give an accurate prognosis remains unclear. A parallel study showed modest agreement between PCP prognosis and observed course (kappa< or = 0...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/s0163-8343(02)00183-4
更新日期：2002-05-01 00:00:00
abstract：:Cannabis in its various forms has been known since time immemorial, the use of which has been rising steadily in India. 'Bad trips' have been documented after cannabis use, manifestations ranging from vague anxiety and fear to profoundly disturbing states of terror and psychosis. Cannabis is known to affect various ne...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2013.06.010
更新日期：2013-11-01 00:00:00
abstract：:As part of a population study on the prevalence of psychopathology, users of "Over-The-Counter" Psychotropics (OTC-Ps) were studied. First, their mental health profile was examined by a number of subjective and objective assessments. Second, the medical consumption of the users was studied with special attention to th...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/s0163-8343(00)00078-5
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVE:This prospective study aimed to estimate the prevalence and course of depression during chemotherapy in women with Stage I-III breast cancer, identify potential risk factors for depression and determine which treatments for depression were being used and which were most preferred. METHOD:Thirty-two women wer...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2013.03.017
更新日期：2013-07-01 00:00:00
abstract：:This study describes and evaluates the adequacy of sociodemographic and clinical descriptors as potential predictors of unplanned discharge from and completion of psychiatric day treatment programs. A 2-year retrospective chart review was completed on all patients (N = 327) attending three university-affiliated day tr...
journal_title：General hospital psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1016/s0163-8343(97)00052-2
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To report a rare case of self-inflicted eye injury secondary to obsessive-compulsive disorder (OCD). METHOD:Case report. RESULTS:A 41 year-old patient had significant bilateral visual loss and blunt trauma through touching his ocular cavities due to recurrent doubts regarding their shape and urges to check ...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2008.08.007
更新日期：2009-05-01 00:00:00
abstract：:Every day there are 6000-7000 papers published in science. Since the C-L psychiatrist may be asked to consult on a patient with any medical illness, and who may be on any medical drug, methods need to be developed to review the recent literature and have an awareness of current findings. At the same time, teachers nee...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/s0163-8343(99)00049-3
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:We describe a patient with prodromal dementia with Lewy bodies (DLB) presenting with drug-induced visual hallucinations (VHs). CASE REPORT:A 78-year-old woman complained of daytime recurrent VHs characterized by seeing her face and arms covered in fur and viewing moustaches on her daughter's face. VHs starte...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2013.02.005
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Adolescent depression has been shown to be associated with later development of obesity. The purpose of this study was to examine the association between depressive symptoms and obesity with progressive pubertal development. METHODS:We conducted an analysis of the association between depressive symptoms and...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2006.03.007
更新日期：2006-07-01 00:00:00
abstract：:A liaison rounds is presented, one attended by all members of a consultation-liaison (C-L) team along with the medical director of a burn unit. This structure is designated as a "reverse liaison rounds," as it is the opposite of the conventional liaison meeting, which consists of one C-L consultant and the total nonps...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(88)90087-4
更新日期：1988-01-01 00:00:00
abstract：:Catatonia is a rare syndrome that occurs in mood and psychotic disorders, and general medical conditions. Postpartum depression affects 10%-15% of women within 6 months after delivery. Postpartum psychosis affects 0.1%-0.5% of women within weeks after delivery, though it can occur within hours; it carries risk for sui...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2011.11.010
更新日期：2012-07-01 00:00:00
abstract：:A structured interview, ADDIS (Alkohol Drog Diagnos InStrument), designed to assess substance use disorders, was included as a part of the intake protocol in a department of orthopedics at a general hospital. To evaluate both the effectiveness and feasibility of the new procedure, the attitudes of 29 staff members wer...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/s0163-8343(96)00088-6
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:Chemical restraint is controversial. Appropriate use is ill-defined and chemical restraint may be overutilized. During the period of an unrelated observational study for patients with acute psychomotor agitation in a psychiatric emergency service, we noticed a significant reduction in the number of involun...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2006.06.001
更新日期：2006-09-01 00:00:00
abstract：INTRODUCTION:Recent surveys have assessed a remarkable increase in the prevalence of infectious syphilis. If left untreated, 30% of patients may develop tertiary syphilis, which can manifest as neurosyphilis. CASE REPORT:The authors present a case of an acute psychosis during and after pregnancy in a 37-year-old woman...
journal_title：General hospital psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.genhosppsych.2008.09.010
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:We investigated the effects of limited time and high patient pressures on the role of gender and other nonpsychiatric factors in diagnostic decision making in psychiatric emergency services (PES). METHODS:We reviewed the records of 1236 adult psychiatric patients treated by 75 clinicians (e.g., psychiatrists...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2007.08.008
更新日期：2007-11-01 00:00:00
abstract：:We report the case of a young man diagnosed with schizophrenia who presented with stalking behaviors that may have been caused by problematic use or participation in social media networks (SMN). We review the possible role of SMN in the formation of his romantic delusion and offer suggestions for clinicians around inc...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2012.10.006
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To investigate the differences in depressive mood and quality of life in patients with between functional dyspepsia (FD), irritable bowel syndrome (IBS), and FD-IBS overlap as diagnosed based on Rome III criteria. METHODS:The subjects completed a questionnaire based on Rome III criteria, the Beck Depressive ...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2010.05.002
更新日期：2010-09-01 00:00:00
abstract：:Detection of nonpsychotic morbidity in primary care patients presenting with nonspecific and somatic symptoms has been difficult because of several factors related to the patients, primary care clinicians, and working conditions of the over-crowded clinic. The available standardized screening questionnaires do not ove...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(91)90021-n
更新日期：1991-03-01 00:00:00
abstract：:The Ras-Raf-mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK cascade is important in the intra-cellular transduction of neurotransmitters, such as dopamine and glutamate. Sorafenib (Nexavar), a multi-kinase inhibitor targeting Raf kinase, vascular endothelial growth factor ...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2012.03.001
更新日期：2014-07-01 00:00:00
abstract：:We report on the case of a patient with acquired immune deficiency syndrome- and Cryptococcus neoformans meningitis-related mania in which olanzapine was successfully used adjunctively and transiently to antifungal therapy. ...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2010.11.004
更新日期：2011-05-01 00:00:00
abstract：:Trichotillomania represents a syndrome of hair pulling in which patients compulsively and ritualistically pluck their hair in response to a sense of tension or urgency. This report documents a case of hair pulling associated with dementia. Neuropsychological testing demonstrated the deficits to be localized predominan...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/s0163-8343(01)00138-4
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:To determine whether a smartphone application (app) with an electronic headache diary and a progressive muscle relaxation (PMR) intervention is feasible and acceptable to people presenting to the Emergency Department (ED) with migraine. METHODS:This single arm prospective study assessed feasibility by actual...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2020.12.009
更新日期：2021-01-08 00:00:00
abstract：OBJECTIVE:Factors determining community tenure (CT) between subsequent referrals to a psychiatric emergency room (PER) are only partly understood. We investigated the differential effect of patient and health system characteristics on the CT of patients with a previous referral to a PER. METHOD:Data were collected for...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2005.04.003
更新日期：2005-07-01 00:00:00
abstract：:The microcomputer allows for the design of a system that functions integrally with both the day-to-day and long-term needs of a consultation-liaison psychiatric service. This article describes a microcomputer system and data structure that can accomplish many of the same research tasks as a minicomputer system. In add...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(85)90022-2
更新日期：1985-04-01 00:00:00
abstract：OBJECTIVE:We investigated the influence of race/ethnicity in diagnostic and disposition decision-making for children and adolescents presenting to an urban psychiatric emergency service (PES). METHOD:Medical records were reviewed for 2991 child and adolescent African-American, Hispanic/Latino and white patients, treat...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2008.01.003
更新日期：2008-05-01 00:00:00
abstract：:The medical-psychiatric unit concept has been the most important influence in the development of general hospital inpatient psychiatry in the last decade. This concept and style of unit organization is reviewed in the context of the history of general hospital inpatient psychiatry. It is suggested that elements of the...
journal_title：General hospital psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0163-8343(94)90083-3
更新日期：1994-01-01 00:00:00
abstract：:Persistent somatization patients put a serious burden on the health care system with multiple admissions, tests, surgeries, and medications. This study reports on factors relevant to the health-seeking behavior of somatizing patients and aspects of the health care system that facilitate their overutilization of health...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(93)90035-m
更新日期：1993-07-01 00:00:00
abstract：:Liaison psychiatry is traditionally practiced on the medical and surgical floors of the general hospital. The need for liaison psychiatry on the inpatient psychiatric unit as opposed to its usual setting was realized when the medical care requirements of hospitalized psychiatric patients was assessed. In many general ...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(80)90028-6
更新日期：1980-06-01 00:00:00
abstract：:Psychological and emotional impairment among physicians represents a serious, widespread, and difficult problem. For unclear reasons, it has been problematic to effectively identify and treat this group of professionals whose performance is so intimately associated with the health and wellbeing of the general populati...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(82)90044-5
更新日期：1982-07-01 00:00:00
abstract：OBJECTIVE:Despite a good prognosis, the typically young age at diagnosis and physical sequelae may cause psychological distress in germ cell tumor survivors. We aimed to determine the frequency of anxiety and depression and analyze the impact of demographic and disease-related factors. METHOD:We enrolled N=164 testicu...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2015.09.001
更新日期：2016-01-01 00:00:00
