Long-term use of acid suppression started inappropriately during hospitalization.

Abstract:

BACKGROUND:Practitioners routinely misuse acid suppression medications on general medical floors and inappropriately continue the drug at discharge. AIMS:To: (i) retrospectively study the appropriateness of acid suppression use on the general medical floors; (ii) characterize the patient population discharged on unnecessary acid suppression and (iii) evaluate whether patients discharged on unnecessary acid suppression continue the medicine long term. METHODS:Retrospective chart review of general medical patients admitted to an in-patient teaching service over 6 consecutive months. RESULTS:About 60% of patients lacked an indication for initiation of acid suppression and 34% of these patients were discharged on the medicine. The only independent predictor of continuation of acid suppression at discharge was longer length of stay. Multivariate analysis did not identify a characteristic distinguishing those patients discharged inappropriately on acid suppression. At 3 and 6 months of follow-up, 80% and 50% of patients, respectively, remained on acid suppression therapy without an appropriate indication. CONCLUSIONS:Our data verifies that practitioners routinely start general medical in-patients on acid suppression without an appropriate indication. Many of these prescriptions are continued at discharge for no apparent reason, leading to their long-term misuse.

journal_name

Aliment Pharmacol Ther

authors

Zink DA,Pohlman M,Barnes M,Cannon ME

doi

10.1111/j.1365-2036.2005.02454.x

subject

Has Abstract

pub_date

2005-05-15 00:00:00

pages

1203-9

issue

10

eissn

0269-2813

issn

1365-2036

pii

APT2454

journal_volume

21

pub_type

杂志文章
  • Characteristics of patients with irritable bowel syndrome recruited from three sources: implications for clinical trials.

    abstract:BACKGROUND:Variation in the characteristics of irritable bowel syndrome patients recruited for clinical trials from different sources could affect their response and the generalizability of trial results. AIM:To describe and compare the characteristics of three different groups of irritable bowel syndrome patients rec...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2036.2001.01010.x

    authors: Longstreth GF,Hawkey CJ,Mayer EA,Jones RH,Naesdal J,Wilson IK,Peacock RA,Wiklund IK

    更新日期:2001-07-01 00:00:00

  • Prevalence, clinical spectrum and atypical symptoms of gastro-oesophageal reflux in Argentina: a nationwide population-based study.

    abstract:BACKGROUND:Population-based data on gastro-oesophageal reflux in Latin America are lacking. AIM:To assess gastro-oesophageal reflux symptom prevalence, clinical spectrum and association with the atypical symptoms in our country. METHODS:Gastro-oesophageal reflux self-report questionnaires validated at Mayo Clinic, US...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2005.02565.x

    authors: Chiocca JC,Olmos JA,Salis GB,Soifer LO,Higa R,Marcolongo M,ARGENTINEAN GASTRO-OESOPHAGEAL REFLUX STUDY GROUP.

    更新日期:2005-08-15 00:00:00

  • Initial potency of lansoprazole and omeprazole tablets on pentagastrin-stimulated gastric acid secretion-a placebo-controlled study in healthy volunteers.

    abstract:BACKGROUND:The new tablet formulation of omeprazole (Losec MUPS), is thought to have a stronger acid inhibition than the previously marketed capsules. METHODS:The effects of the proton pump inhibitors lansoprazole and omeprazole tablets on pentagastrin-stimulated acid secretion were compared in Helicobacter pylori-neg...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2036.2000.00823.x

    authors: Müller P,Göksu MA,Fuchs W,Schlüter F,Simon B

    更新日期:2000-09-01 00:00:00

  • Pilot study: Gelafundin (polygeline) 4% plus antibiotics in the treatment of high-risk cirrhotic patients with spontaneous bacterial peritonitis.

    abstract:BACKGROUND:Cirrhotic patients with spontaneous bacterial peritonitis (SBP) have elevated rates of renal impairment and mortality. It has been shown that cefotaxime plus albumin infusion decrease renal impairment compared with antibiotic treatment alone, in patients with serum bilirubin >4 mg/dL or creatinine >1 mg/dL. ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2010.04309.x

    authors: Cartier M,Terg R,Lucero R,Muñoz A,Romero G,Levi D,Miguez C,Abecasis R

    更新日期:2010-07-01 00:00:00

  • Review article: gastroparesis.

    abstract:BACKGROUND:Gastroparesis is a chronic disorder caused by stomach pump failure and characterized by profound nausea, vomiting and epigastric pain. Most often, the cause is unapparent and of the known associations, diabetes is the most common. Diagnosis is usually made using an isotope-labelled test meal. Treatment is in...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2008.03637.x

    authors: Patrick A,Epstein O

    更新日期:2008-05-01 00:00:00

  • Comparison of the effects of intravenously and orally administered esomeprazole on acid output in patients with symptoms of gastro-oesophageal reflux disease.

    abstract:BACKGROUND:Intravenous esomeprazole may be beneficial for patients who cannot take oral medications. AIM:To compare intravenous esomeprazole with oral esomeprazole for effects on maximal acid output during pentagastrin stimulation in patients with gastro-oesophageal reflux disease symptoms. METHODS:In four separate o...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1365-2036.2005.02659.x

    authors: Metz DC,Miner PB,Heuman DM,Chen Y,Sostek M

    更新日期:2005-11-01 00:00:00

  • Coexistence between colorectal cancer/adenoma and coronary artery disease: results from 1382 patients.

    abstract:BACKGROUND:Common risk factors exist in colorectal neoplasia (cancer or adenoma) and coronary artery disease. AIM:To investigate in a retrospective study if there is coexistence of the two events in patients > OR =50 years. METHODS:Computer data on colonoscopies performed on symptomatic patients, the corresponding me...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2006.02958.x

    authors: Chan AO,Lam KF,Tong T,Siu DC,Jim MH,Hui WM,Lai KC,Yuen MF,Lam SK,Wong BC

    更新日期:2006-08-01 00:00:00

  • Meta-analysis: allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitis.

    abstract:BACKGROUND:Several clinical trials evaluating the prophylactic effect of allopurinol on postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis have been published; however, there is no consensus on whether prophylactic allopurinol can reduce the incidence of post-ERCP pancreatitis. AIM:To compare proph...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1365-2036.2008.03756.x

    authors: Bai Y,Gao J,Zhang W,Zou D,Li Z

    更新日期:2008-09-01 00:00:00

  • Review article: gastric pH -- the most relevant predictor of benefit in reflux disease?

    abstract::Summary In patients with gastro-oesophageal reflux disease, the pH of refluxed gastric contents has a direct bearing on disease severity and oesophageal damage. A pH of 4 has been defined as a threshold below which refluxed gastric contents become injurious to the oesophagus. Studies in patients with erosive oesophagi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2004.02140.x

    authors: Armstrong D

    更新日期:2004-10-01 00:00:00

  • Review article: endoscopy-related infections.

    abstract::Endoscopic procedures generate bacteraemia to different degrees. Under certain conditions, most notably valvular heart disease, clinically significant infections may occur. A large body of literature has grown around recommendations for antibiotic prophylaxis to prevent procedure-related infections. Most of this liter...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:

    authors: Schembre D,Bjorkman DJ

    更新日期:1993-08-01 00:00:00

  • Review article: liver transplantation for the pulmonary disorders of portal hypertension.

    abstract:BACKGROUND:Liver transplantation is potentially a life-saving therapeutic intervention for patients with portopulmonary hypertension and hepatopulmonary syndrome. However, due to limited data, listing criteria for patients with these conditions have not been clearly established. Indeed, this has led some to speculate t...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/apt.12140

    authors: Houlihan DD,Holt A,Elliot C,Ferguson JW

    更新日期:2013-01-01 00:00:00

  • Low-dose lansoprazole and clarithromycin plus metronidazole vs. full-dose lansoprazole and clarithromycin plus amoxicillin for eradication of Helicobacter pylori infection.

    abstract:AIM:To compare, in a randomized controlled trial, the efficacy and tolerability of two 1-week triple therapies for Helicobacter pylori eradication. METHODS:One hundred and thirty-four consecutive patients with non-ulcer dyspepsia and H. pylori infection were randomized to receive lansoprazole 30 mg once daily, clarith...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2036.2002.01141.x

    authors: Bazzoli F,Zagari RM,Pozzato P,Fossi S,Ricciardiello L,Nicolini G,De Luca L,Berretti D,Alampi G,Di Pietro C,Morelli P,Roda E

    更新日期:2002-01-01 00:00:00

  • Review article: direct-acting antivirals for the treatment of HCV during pregnancy and lactation - implications for maternal dosing, foetal exposure, and safety for mother and child.

    abstract:BACKGROUND:With the global efforts to eradicate hepatitis C virus (HCV), treatment during pregnancy is becoming a priority for research as this, and maternal cure should reduce vertical transmission. However, as information on the efficacy and safety of direct-acting antivirals (DAAs) in pregnancy is generally lacking,...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/apt.15476

    authors: Freriksen JJM,van Seyen M,Judd A,Gibb DM,Collins IJ,Greupink R,Russel FGM,Drenth JPH,Colbers A,Burger DM

    更新日期:2019-10-01 00:00:00

  • Serum pepsinogen 1 and anti-Helicobacter pylori IgG antibodies as predictors of gastric cancer risk in Finnish males.

    abstract:BACKGROUND:Serum pepsinogen 1 (SPG1) and anti-Helicobacter pylori serology have been used for gastric risk stratification in Asia. AIM:To assess utility of these markers in a Western population. METHODS:SPG1 measurements were available for 21 895 Finnish male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prev...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.14471

    authors: Song M,Camargo MC,Weinstein SJ,Murphy G,Freedman ND,Koshiol J,Stolzenberg-Solomon RZ,Abnet CC,Männistö S,Albanes D,Rabkin CS

    更新日期:2018-02-01 00:00:00

  • The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients.

    abstract:BACKGROUND:In vitro studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S-methyltransferase (TPMT) inhibition, influencing the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive tioguanine (thioguanine) metabolites. AIM:To examine the in vivo pharm...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2036.2005.02630.x

    authors: Gilissen LP,Bierau J,Derijks LJ,Bos LP,Hooymans PM,van Gennip A,Stockbrügger RW,Engels LG

    更新日期:2005-10-01 00:00:00

  • Capsule endoscopy - comparison of two strategies of bowel preparation.

    abstract:BACKGROUND:Capsule endoscopy can identify lesions of the small bowel that cannot be detected by other techniques. In addition to patient safety, quality of care and cost-efficiency, good preparation is an important factor for good visualization. AIM:To evaluate the efficacy of oral sodium phosphate preparation. METHO...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2036.2005.02647.x

    authors: Niv Y,Niv G,Wiser K,Demarco DC

    更新日期:2005-11-15 00:00:00

  • High-dose, ten-day esomeprazole, amoxicillin and metronidazole triple therapy achieves high Helicobacter pylori eradication rates.

    abstract:BACKGROUND:Strong acid inhibition using esomeprazole increases cure rates with triple therapy and 10-day treatments are more effective than 7-day ones. The combination of amoxicillin plus metronidazole at full doses, and using a physiologically-correct schedule three times a day, and has been shown to overcome metronid...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2012.05137.x

    authors: Sánchez-Delgado J,García-Iglesias P,Castro-Fernández M,Bory F,Barenys M,Bujanda L,Lisozain J,Calvo MM,Torra S,Gisbert JP,Calvet X

    更新日期:2012-07-01 00:00:00

  • Personal view: adequate relief as a primary endpoint in irritable bowel syndrome.

    abstract::The success of a clinical trial is judged by achieving statistical and clinical significance on the primary endpoint. This is particularly relevant in those trials that are initiated to achieve regulatory approval of a new therapeutic agent. Selection of an endpoint for which statistical significance will be too diffi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2006.02839.x

    authors: Mangel AW

    更新日期:2006-04-01 00:00:00

  • Endoscopic ablation of Barrett's oesophagus: a randomized-controlled trial of photodynamic therapy vs. argon plasma coagulation.

    abstract:BACKGROUND:Barrett's oesophagus is the major risk factor for oesophageal adenocarcinoma. 5-Aminlevulinic acid-induced photodynamic therapy and argon plasma coagulation have been shown to be effective for ablating Barrett's oesophagus, but a comparative trial of these two modalities has not been reported. AIMS:To compa...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2036.2004.02277.x

    authors: Kelty CJ,Ackroyd R,Brown NJ,Stephenson TJ,Stoddard CJ,Reed MW

    更新日期:2004-12-01 00:00:00

  • Patterns of 24-hour oesophageal acid exposure after acute withdrawal of acid suppression.

    abstract:AIM:To measure 24-h ambulatory oesophageal pH data in patients with gastro-oesophageal reflux disease prior to, during and after acute treatment with comparable doses of omeprazole and ranitidine. METHODS:The subjects were 20 adults with at least 8% acid contact time. Ten subjects were treated for 1 week with omeprazo...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2036.1995.tb00423.x

    authors: Orr WC,Mellow MH,Grossman MR

    更新日期:1995-10-01 00:00:00

  • Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowth.

    abstract:BACKGROUND:Many studies report a high prevalence of lactose intolerance in patients with functional, gastrointestinal disease. AIM:To evaluate the role of small intestinal bacterial overgrowth (SIBO) in condition of lactose intolerance and the mechanism by which SIBO may impact lactose tolerance in affected patients. ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2010.04252.x

    authors: Zhao J,Fox M,Cong Y,Chu H,Shang Y,Fried M,Dai N

    更新日期:2010-04-01 00:00:00

  • Rifaximin in the treatment of recurrent Clostridium difficile infection.

    abstract:BACKGROUND:Clostridium difficile can cause severe antibiotic-associated colitis. Conventional treatments with metronidazole and vancomycin improve symptoms, but after discontinuation of treatment, C. difficile infection (CDI) recurs in a number of patients. Rifaximin is a rifamycin-based non-systemic antibiotic that ha...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.12111

    authors: Mattila E,Arkkila P,Mattila PS,Tarkka E,Tissari P,Anttila VJ

    更新日期:2013-01-01 00:00:00

  • A rapid-release 50-mg tablet-based 13C-urea breath test for the diagnosis of Helicobacter pylori infection.

    abstract:BACKGROUND:Recently, a rapid-release 100-mg 13C-urea tablet with citrate supplement (Diabact UBT) showed excellent performance in a European population. AIM:To investigate the accuracy of a 50-mg tablet-based 13C-urea breath test protocol. METHODS:: Consecutive dyspeptic patients referred for upper endoscopy were rec...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2036.2003.01417.x

    authors: Wong WM,Lam SK,Lai KC,Chu KM,Xia HH,Wong KW,Cheung KL,Lin SK,Wong BC

    更新日期:2003-01-01 00:00:00

  • Efficacy and safety of ribavirin plus pegylated interferon alfa in geriatric patients with chronic hepatitis C.

    abstract:BACKGROUND:Limited data are available on the efficacy and safety of antiviral therapy in geriatric patients with chronic hepatitis C virus (HCV) infection. AIM:To evaluate the efficacy and safety of pegylated interferon (pegIFN) plus ribavirin (RBV) therapy in geriatric HCV-infected patients. METHODS:Ninety-one geria...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.12112

    authors: Hu CC,Lin CL,Kuo YL,Chien CH,Chen SW,Yen CL,Lin CY,Chien RN

    更新日期:2013-01-01 00:00:00

  • Review article: 'true' re-infection of Helicobacter pylori after successful eradication--worldwide annual rates, risk factors and clinical implications.

    abstract:BACKGROUND:The incidence of 'true' re-infection with Helicobacter pylori after successful eradication remains uncertain. AIM:To determine the worldwide rates, risk factors and clinical implications of 'true' re-infection of Helicobacter pylori. 'True' re-infection of H. pylori is defined as the situation where tests f...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2008.03873.x

    authors: Zhang YY,Xia HH,Zhuang ZH,Zhong J

    更新日期:2009-01-01 00:00:00

  • Real-life study of safety of thiopurine-allopurinol combination therapy in inflammatory bowel disease: myelotoxicity and hepatotoxicity rarely affect maintenance treatment.

    abstract:BACKGROUND:Low-dose thiopurine-allopurinol (LDTA) combination therapy is a commonly applied optimisation strategy in IBD patients with a skewed thiopurine metabolism. AIM:To assess continued LDTA maintenance treatment at annual intervals and explore risk factors for treatment cessation METHODS: Adult IBD patients trea...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.15402

    authors: Kreijne JE,de Veer RC,de Boer NK,Dijkstra G,West R,Moorsel SAW,de Jong DJ,van der Woude CJ,de Vries AC,of the Dutch Initiative on Crohn, Colitis (ICC).

    更新日期:2019-08-01 00:00:00

  • Bacterial infection and neutropenia during peginterferon plus ribavirin combination therapy in patients with chronic hepatitis C with and without baseline neutropenia in clinical practice.

    abstract:BACKGROUND:Peginterferon-alpha-based therapy frequently leads to neutropenia. It remains unclear whether neutropenia is associated with bacterial infection in chronic hepatitis C (CHC). AIM:To evaluate the risk of bacterial infection and neutropenia in patients with CHC treated with peginterferon-alpha/ribavirin. MET...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2009.03957.x

    authors: Yang JF,Hsieh MY,Hou NJ,Dai CY,Huang JF,Lin ZY,Chen SC,Hsieh MY,Wang LY,Chuang WL,Yu ML

    更新日期:2009-05-01 00:00:00

  • The anti-viral effect of sorafenib in hepatitis C-related hepatocellular carcinoma.

    abstract:BACKGROUND:Sorafenib is currently the only approved systemic therapy shown to have efficacy in the treatment of advanced hepatocellular carcinoma (HCC). Recent studies suggest that hepatitis C (HCV)-related HCC patients derive more clinical benefit from sorafenib than other subgroups, but the mechanism for this effect ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.12098

    authors: Cabrera R,Limaye AR,Horne P,Mills R,Soldevila-Pico C,Clark V,Morelli G,Firpi R,Nelson DR

    更新日期:2013-01-01 00:00:00

  • Helicobacter pylori eradication using one-week low-dose lansoprazole plus amoxycillin and either clarithromycin or azithromycin.

    abstract:AIM:To evaluate and compare two 1-week low-dose triple therapies based on lansoprazole, amoxycillin and a macrolide in eradicating Helicobacter pylori. METHODS:Seventy consecutive patients, suffering from dyspeptic symptoms with H. pylori infection, were randomly allocated to one of two treatment groups: (A) (LAC; n =...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2036.1996.d01-533.x

    authors: Cammarota G,Tursi A,Papa A,Montalto M,Veneto G,Cuoco L,Fedeli G,Gasbarrini G

    更新日期:1996-12-01 00:00:00

  • Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments.

    abstract:BACKGROUND:The most commonly used second-line Helicobacter pylori eradication regimens are bismuth-containing quadruple therapy and levofloxacin-containing triple therapy, both offering suboptimal results. Combining bismuth and levofloxacin may enhance the efficacy of rescue eradication regimens. AIMS:To evaluate the ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/apt.13128

    authors: Gisbert JP,Romano M,Gravina AG,Solís-Muñoz P,Bermejo F,Molina-Infante J,Castro-Fernández M,Ortuño J,Lucendo AJ,Herranz M,Modolell I,Del Castillo F,Gómez J,Barrio J,Velayos B,Gómez B,Domínguez JL,Miranda A,Martorano M

    更新日期:2015-04-01 00:00:00