Sex steroid level, androgen receptor polymorphism, and depressive symptoms in healthy elderly men.


OBJECTIVES:To determine the prevalence of depression in a cohort of elderly men as assessed using a 30-item Geriatric Depression Scale (GDS) score and to describe the association between this score and sex steroids, androgen receptor (AR) polymorphism, and general health status. DESIGN:Observational study on the relationship between sex steroid status and health-related parameters. SETTING:Community-based. PARTICIPANTS:Ambulatory men (n=236 in 1997, n=192 in 2000) aged 70 and older at inclusion in 1996, interviewed in 1997 and 2000. MEASUREMENTS:Serum levels of testosterone, estradiol, sex hormone binding globulin (SHBG), dehydroepiandrosterone-sulfate (DHEAS), cortisol, and the AR gene cytosine, adenine, guanine (CAG)-repeat length polymorphism were determined. Free testosterone and free estradiol were calculated. Questionnaires included GDS, 36-item Short Form, and Rapid Disability Rating Scale-2. RESULTS:Median age was 75.3 years (interquartile range=73.5-78.5). A GDS score of 11 or greater was found in 30 (12.7%) men. Age and GDS score were significantly interrelated (P<.01), as were all health-assessment scores. GDS scores were not related to (free) testosterone or AR polymorphism in 1997 or 2000. In 1997 only (n=236), higher GDS scores were related to higher estradiol, free estradiol, and DHEAS levels. CONCLUSION:The data did not support a role for testosterone in depression in elderly community-based men as assessed using the GDS.


J Am Geriatr Soc


T'Sjoen GG,De Vos S,Goemaere S,Van Pottelbergh I,Dierick M,Van Heeringen C,Kaufman JM




Has Abstract


2005-04-01 00:00:00














  • "Because I was sick": seriously ill veterans' perspectives on reason for 30-day readmissions.

    abstract:OBJECTIVES:To determine the perspectives of seriously ill individuals on reasons for 30-day hospital readmission. DESIGN:A prospective qualitative study was conducted employing individual interviews conducted at bedside. SETTING:Department of Veterans Affairs Greater Los Angeles Healthcare System. PARTICIPANTS:Serio...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Enguidanos S,Coulourides Kogan AM,Schreibeis-Baum H,Lendon J,Lorenz K

    更新日期:2015-03-01 00:00:00

  • Hepatitis C Virus Clearance in Older Adults.

    abstract:OBJECTIVES:To determine whether older adults with the hepatitis C virus (HCV) achieve a sustained viral response (SVR) after treatment with direct-acting antiviral therapy. PARTICIPANTS:Individuals aged 80 and older with chronic HCV infection (N = 253; n = 213 with cirrhosis, n = 40 with advanced fibrosis). MEASUREME...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Ippolito AM,Iacobellis A,Milella M,Conti F,Messina V,Valvano MR,Niro GA,Morisco F,Barone M,Termite AP,Brancaccio G,Andriulli A

    更新日期:2018-01-01 00:00:00

  • Cost-Effectiveness of the 4 Pillars Practice Transformation Program to Improve Vaccination of Adults Aged 65 and Older.

    abstract:OBJECTIVES:To estimate the cost-effectiveness of an intervention to increase pneumococcal, influenza, and pertussis-containing vaccine uptake in adults aged 65 and older in primary care practices. DESIGN:Markov decision analysis model, comparing the cost-effectiveness of the 4 Pillars Practice Transformation Program w...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Smith KJ,Zimmerman RK,Nowalk MP,Lin CJ

    更新日期:2017-04-01 00:00:00

  • Memory complaint in a community sample aged 70 and older.

    abstract:OBJECTIVES:The ability of older people to estimate their own memory, often referred to as "metamemory," has been evaluated in previous studies with conflicting reports regarding accuracy. Some studies have suggested that an older person's metamemory is mostly accurate, whereas others have demonstrated little relationsh...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Turvey CL,Schultz S,Arndt S,Wallace RB,Herzog R

    更新日期:2000-11-01 00:00:00

  • Reflections on Hope and Its Implications for End-of-Life Care.

    abstract::Physicians caring for individuals with life-altering, incurable illnesses often have a desire to convey a sense of hope while also helping their patients prepare for the end of life to minimize unnecessary suffering and grief. Unfortunately, in the United States, most people receive more-aggressive treatments toward t...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Mattes MD,Sloane MA

    更新日期:2015-05-01 00:00:00

  • Incidence of hypertension in an ambulatory elderly population.

    abstract::Investigations of the natural history of blood pressure have generally evaluated mean systolic and diastolic pressure changes. While information, this information is not directly applicable to clinical practice settings, in which patients are usually classified as normotensive or hypertensive. We measured the actual i...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Davidson RA,Hale WE,Moore MT,May FE,Marks RG,Stewart RB

    更新日期:1989-09-01 00:00:00

  • Neurotransmitter deficits in Alzheimer's disease: criteria for significance.

    abstract::A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter-deficiency syndrome, Parkinson's disease, validates these criteria. The major ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: Greenwald BS,Mohs RC,Davis KL

    更新日期:1983-05-01 00:00:00

  • Self-reported social and emotional impact of urinary incontinence.

    abstract:OBJECTIVE:Incontinence-specific and generic measures of well-being were regressed on potential predictors to identify incontinent respondents at risk for psychosocial distress and to understand the relationship between urinary incontinence (UI) and other determinants of social and emotional status. DESIGN:Survey data ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Fultz NH,Herzog AR

    更新日期:2001-07-01 00:00:00

  • Reduced serum albumin concentration in the elderly: a report from the Boston Collaborative Drug Surveillance Program.

    abstract::The relation of serum albumin concentration to age was assessed in a series of hospitalized medical patients. Those with disease states (e.g., dysproteinemia, renal insufficiency, hepatic dysfunction, malnutrition) potentially associated with abnormal serum albumin levels were excluded, leaving a study population of 1...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Greenblatt DJ

    更新日期:1979-01-01 00:00:00

  • Circumstances of falls resulting in hip fractures among older people.

    abstract:OBJECTIVES:To describe the circumstances of falls resulting in hip fractures among older people and to determine whether the circumstances differ by gender, age, and residential status. DESIGN:Cross-sectional study. SETTING:Two hospitals in Auckland, New Zealand, in which all individuals aged 60 years or older with a...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Norton R,Campbell AJ,Lee-Joe T,Robinson E,Butler M

    更新日期:1997-09-01 00:00:00

  • Oral Health, Diet, and Frailty at Baseline of the Canadian Longitudinal Study on Aging.

    abstract:OBJECTIVES:Poor diet due to poor oral health was proposed as a potential mediator of the association between poor oral health and frailty. This study explores the cross-sectional associations between poor oral health, poor diet, and frailty in Canadian adults, aged 45 to 85 years, and then tests whether the expected or...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Bassim C,Mayhew AJ,Ma J,Kanters D,Verschoor CP,Griffith LE,Raina P

    更新日期:2020-05-01 00:00:00

  • Incidence of and predictors for chronic disability in activities of daily living among older people in Taiwan.

    abstract:OBJECTIVES:To estimate the incidence of chronic activities of daily living (ADL) disability and to analyze the sociodemographic, health status, adverse lifestyle, and leisure-time physical activity predictors for chronic ADL disability. DESIGN:We recruited a cohort of community-dwelling older people in Taipei, Taiwan,...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Wu SC,Leu SY,Li CY

    更新日期:1999-09-01 00:00:00

  • Differences in the signs and symptoms of hyperthyroidism in older and younger patients.

    abstract:OBJECTIVES:To determine if aging modifies the clinical presentation of hyperthyroidism and the signs of thyrotoxicosis in older people. DESIGN:Prospective cohort study. SETTING:A French university hospital. SUBJECTS:Eighty-four new patients with overt hyperthyroidism confirmed chemically between January 1992 and Jan...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Trivalle C,Doucet J,Chassagne P,Landrin I,Kadri N,Menard JF,Bercoff E

    更新日期:1996-01-01 00:00:00

  • Dementia and other competing risks for mortality in the institutionalized aged.

    abstract::The relative importance of dementia, gender, age and functional status (FS) was examined for relationships to mortality within five years after admission of the subjects to a New York City nursing home for the aged. Using a random sample of 212 of the nursing home's patients, a statistical model was developed to estim...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Vitaliano PP,Peck A,Johnson DA,Prinz PN,Eisdorfer C

    更新日期:1981-11-01 00:00:00

  • A randomized controlled trial of an automated exercise coach for older adults.

    abstract:OBJECTIVES:To compare the efficacy of a computer-based physical activity program (Embodied Conversational Agent-ECA) with that of a pedometer control condition in sedentary older adults. DESIGN:Single-blind block-randomized controlled trial stratified according to clinic site and health literacy status. SETTING:Three...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验


    authors: Bickmore TW,Silliman RA,Nelson K,Cheng DM,Winter M,Henault L,Paasche-Orlow MK

    更新日期:2013-10-01 00:00:00

  • Leadership, Inside and Out: The Tideswell-AGS-ADGAP Emerging Leaders in Aging Program.

    abstract:BACKGROUND/OBJECTIVES:To optimize health and well-being for all older people, we must collectively develop leaders to pioneer models of care, educate the healthcare workforce, advance research, and engage the community. METHODS:The Emerging Leaders in Aging (ELIA) program was created to train a multiprofessional cadre...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Chang A,Lundebjerg NE,Abrams J,Barnes DE,Fain MJ,Hall WJ,Johnson TM 2nd,Michael Harper G,Williams B,Ritchie CS

    更新日期:2019-03-01 00:00:00

  • Demographic characteristics and healthcare use of centenarians: a population-based cohort study.

    abstract:OBJECTIVES:To better understand how centenarians use the healthcare system as an important step toward improving their service delivery. DESIGN:Population-based retrospective cohort study using linked health administrative data. SETTING:Ontario--Canada's largest province. PARTICIPANTS:All individuals living in Ontar...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Rochon PA,Gruneir A,Wu W,Gill SS,Bronskill SE,Seitz DP,Bell CM,Fischer HD,Stephenson AL,Wang X,Gershon AS,Anderson GM

    更新日期:2014-01-01 00:00:00

  • Monitoring of Potentially Inappropriate Prescriptions in Older Inpatients: A French Multicenter Study.

    abstract:OBJECTIVES:To determine whether potentially inappropriate medications (PIMs) or potentially inappropriate associations (PIAs) prescribed knowingly are associated with patient monitoring. DESIGN:Prospective observational study. SETTING:Geriatric units (n = 56) in 28 hospitals. PARTICIPANTS:Inpatients aged 75 and olde...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究


    authors: Pandraud-Riguet I,Bonnet-Zamponi D,Bourcier E,Buyse M,Laribe-Caget S,Frémont P,Pautas E,Verny C,Hindlet P,Fernandez C

    更新日期:2017-12-01 00:00:00

  • Conceptual challenges and practical approaches to screening capacity for self-care and protection in vulnerable older adults.

    abstract::Identifying impairments in the capacity to make and execute decisions is critical to the assessment and remediation of elder self-neglect. Few capacity assessment tools are available for use outside of healthcare settings, and none have been validated in the context of elder self-neglect. Health and social services pr...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: Naik AD,Teal CR,Pavlik VN,Dyer CB,McCullough LB

    更新日期:2008-11-01 00:00:00

  • Septic arthritis in patients aged 80 and older: a comparison with younger adults.

    abstract:OBJECTIVES:To compare the frequency and characteristics of septic arthritis in patients younger than 80 and aged 80 and older. DESIGN:Retrospective. SETTING:Single hospital center. PARTICIPANTS:Patients admitted between 1979 and 2002 for septic arthritis. MEASUREMENTS:Age, sex, time to diagnosis, predisposing facto...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Gavet F,Tournadre A,Soubrier M,Ristori JM,Dubost JJ

    更新日期:2005-07-01 00:00:00

  • National trends in the initial hospitalization for heart failure.

    abstract:OBJECTIVES:Heart failure is a major health care burden among older adults, but information on recent trends has not been available. We compare rates, sociodemographic characteristics, and discharge outcomes of the initial hospitalization for heart failure in the Medicare populations of 1986 and 1993. DESIGN:Informatio...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Croft JB,Giles WH,Pollard RA,Casper ML,Anda RF,Livengood JR

    更新日期:1997-03-01 00:00:00

  • Salivary gland fluid secretion during aging.

    abstract::Salivary gland function is generally well-preserved in healthy older persons. Similar results are observed in the laboratory rat. Older people are, however, more likely to experience salivary disorders due to disease or its treatment. For many patients with remaining salivary gland parenchymal tissue, improved functio...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: Baum BJ

    更新日期:1989-05-01 00:00:00

  • Multimorbidity and Risk of Mild Cognitive Impairment.

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Vassilaki M,Aakre JA,Cha RH,Kremers WK,St Sauver JL,Mielke MM,Geda YE,Machulda MM,Knopman DS,Petersen RC,Roberts RO

    更新日期:2015-09-01 00:00:00

  • An alternative model in geriatric care.

    abstract::An analysis is presented of one long-term care facility's attempt to develop a comprehensive geriatric program including care of the patient in a hospital, a skilled nursing home, a day hospital, or a clinic for care of the ambulatory aged. The goal was to raise issues for debate and discussion, especially in terms of...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Ingman SR,McDonald CA,Lusky R

    更新日期:1979-06-01 00:00:00

  • Drug therapy for cardiovascular disease in the aged.

    abstract::Cardiovascular diseases and their treatment in the aged are discussed under the headings of ischemic heart disease, hypertension, cardiac failure (with special reference to the use of diuretics and digoxin), infective carditis and thyroid disorders. Advanced age modifies the approach to treatment; the choice of drugs ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: Kennedy RD

    更新日期:1975-03-01 00:00:00

  • Development of a physical performance and mobility examination.

    abstract:OBJECTIVE:To develop and validate the Physical Performance and Mobility Examination (PPME), an observer-administered, performance-based instrument assessing 6 domains of physical functioning and mobility for hospitalized elderly. DESIGN:Development of a pass-fail and 3-level scoring system and training manuals for the...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Winograd CH,Lemsky CM,Nevitt MC,Nordstrom TM,Stewart AL,Miller CJ,Bloch DA

    更新日期:1994-07-01 00:00:00

  • Use of the physician orders for life-sustaining treatment program in the clinical setting: a systematic review of the literature.

    abstract::The Physician Orders for Life-Sustaining Treatment (POLST) form is a palliative care tool that contains standardized, actionable medical orders. It is designed to ensure that patient treatment preferences are elicited, communicated, and honored throughout the healthcare system. A systematic review of the literature wa...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: Hickman SE,Keevern E,Hammes BJ

    更新日期:2015-02-01 00:00:00

  • Troublesome and disruptive behaviors in dementia. Relationships to diagnosis and disease severity.

    abstract::Patients with dementia often manifest troublesome and disruptive behaviors in addition to intellectual impairments. This study evaluated behavioral disturbances in 126 demented patients examined sequentially, using questionnaires administered to primary caregivers to quantify the types and severity of behavioral distu...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Swearer JM,Drachman DA,O'Donnell BF,Mitchell AL

    更新日期:1988-09-01 00:00:00

  • Outcomes of displaced and nondisplaced pelvic and sacral fractures in elderly adults.

    abstract:OBJECTIVES:To identify fracture types in a series of older adults with pelvic fractures and to determine whether the type of pelvic fracture affected short-term outcomes and morbidity. DESIGN:Retrospective chart review. SETTING:Teaching hospital. PARTICIPANTS:One hundred eighty-one individuals aged 65 and older with...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Mears SC,Berry DJ

    更新日期:2011-07-01 00:00:00

  • American Geriatrics Society identifies another five things that healthcare providers and patients should question.

    abstract::Since 2012, the American Geriatrics Society (AGS) has also been collaborating with the American Board of Internal Medicine (ABIM) Foundation, joining its "Choosing Wisely" campaign on two separate lists of Five Things Healthcare Providers and Patients Should Question. The campaign is designed to engage healthcare orga...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: AGS Choosing Wisely Workgroup.

    更新日期:2014-05-01 00:00:00