Abstract:
:The success of the human genome sequencing project has created wide-spread interest in exploring the human epigenome in order to elucidate how the genome executes the information it holds. Although all (nucleated) human cells effectively contain the same genome, they contain very different epigenomes depending upon cell type, developmental stage, sex, age and various other parameters. This complexity makes it intrinsically difficult to precisely define 'an' epigenome, let alone 'the' epigenome. What is clear, however, is that in order to unravel any epigenome, existing and novel high-throughput approaches on the DNA, RNA and protein levels need to be harnessed and integrated. Here, we review the current thinking and progress on how to get from the genome to the epigenome(s) and discuss some potential applications.
journal_name
Hum Mol Genetjournal_title
Human molecular geneticsauthors
Murrell A,Rakyan VK,Beck Sdoi
10.1093/hmg/ddi110subject
Has Abstractpub_date
2005-04-15 00:00:00pages
R3-R10eissn
0964-6906issn
1460-2083pii
14/suppl_1/R3journal_volume
14 Spec No 1pub_type
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