Abstract:
:Pathological modifications in the microtubule-associated protein Tau is a common characteristic observed in different neurological diseases, suggesting that analogous metabolic pathways might be similarly affected during neurodegeneration. To identify these molecules and mechanisms, we utilized Drosophila models of human Tau-mediated neurodegeneration to perform an RNA interference functional screening against genes considered to be implicated in the pathogenesis of different neurodegenerative disorders. We found that the downregulation of the Drosophila REEP1 homolog protein enhanced Tau toxicity with increased formation of insoluble aggregates. On the contrary, the overexpression of either the Drosophila or the human REEP1 protein was able to revert these phenotypes and promote neuronal resistance to ER stress. These studies identify a new function for the REEP1 protein in vivo and a novel cellular mechanism to prevent Tau toxicity.
journal_name
Hum Mol Genetjournal_title
Human molecular geneticsauthors
Appocher C,Klima R,Feiguin Fdoi
10.1093/hmg/ddu393subject
Has Abstractpub_date
2014-12-20 00:00:00pages
6762-72issue
25eissn
0964-6906issn
1460-2083pii
ddu393journal_volume
23pub_type
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