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Cytochrome P-450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes.

Abstract：

:The effect of non-insulin-dependent diabetes on the hepatic microsomal cytochrome P450-dependent mixed-function oxidase system and on cytosolic glutathione S-transferase activity was determined using the spontaneously obese-diabetic (ob/ob) mouse model. The activities of the xenobiotic-metabolizing cytochrome P450 proteins were monitored by the use of chemical probes. Non-insulin-dependent diabetes did not influence the hepatic metabolism of substrates associated with the P450 I, IIB, IIE, III and IV families of cytochromes. In contrast, cytosolic glutathione S-transferase activity was markedly reduced and glutathione levels were significantly lowered. These findings raise the possibility that patients suffering from this disease may be more susceptible to chemicals that rely on glutathione conjugation for their deactivation.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Barnett CR,Abbott RA,Bailey CJ,Flatt PR,Ioannides C

doi

10.1016/0006-2952(92)90724-w

subject

Has Abstract

pub_date

1992-04-15 00:00:00

pages

1868-71

issue

8

eissn

0006-2952

issn

1873-2968

pii

0006-2952(92)90724-W

journal_volume

43

pub_type

杂志文章

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