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Oesophageal pH has a power-law distribution in control and gastro-oesophageal reflux disease subjects.

Abstract：

BACKGROUND:We are unaware of any solid theoretical or pathophysiological basis for selecting pH 4 or any other pH value to assess oesophageal acid exposure or to define oesophageal reflux episodes. AIM:To examine the frequency of different oesophageal pH values in control and GERD subjects. METHODS:Oesophageal pH was measured for 24 h in 57 gastro-oesophageal reflux disease subjects and 26 control subjects. Histograms were constructed using the 21,600 values from each recording and bins of 0.25 pH units. RESULTS:Compared with controls, gastro-oesophageal reflux disease subjects had significantly more low pH values and significantly fewer high pH values. In both gastro-oesophageal reflux disease and control subjects, the frequency of oesophageal pH values was characterized by a power-law distribution indicating that the same relationship that describes low pH values also describes high pH values, as well as all values in between. CONCLUSIONS:The distribution of oesophageal pH values indicates that a variety of different pH values can be used to assess oesophageal acid exposure, but raises important questions regarding how oesophageal reflux episodes are defined.

journal_name

Aliment Pharmacol Ther

journal_title

Alimentary pharmacology & therapeutics

authors

Gardner JD,Sloan S,Robinson M,Miner PB

doi

10.1111/j.1365-2036.2004.02278.x

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

1373-9

issue

11-12

eissn

0269-2813

issn

1365-2036

pii

APT2278

journal_volume

20

pub_type

临床试验,杂志文章

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