Mitochondrial sequence variation in the Guahibo Amerindian population from Venezuela.

Abstract:

:New data were obtained on mitochondrial DNA (mtDNA) from Guahibo from Venezuela, a group so far not studied using molecular data. A population sample (n = 59) was analyzed for mtDNA variation in two control-region hypervariable segments (HV1 and HV2) by sequencing. The presence or absence of a 9-bp polymorphism in the COII/tRNA(Lys) region was studied by direct amplification and electrophoretic identification. Thirty-eight variable sites were detected in regions HV1 and HV2, defining 26 mtDNA lineages; 23.7% of these were present in a single individual. The 9-bp deletion was found in 3.39% of individuals. Nucleotide and haplotype diversities were relatively high compared with other New World populations. The identified sequence haplotypes were classified into four major haplogroups (A-D) according to previous studies, with high frequencies for A (47.46%) and C (49.15%), low frequency for B (3.39%), and an absence of D.

journal_name

Am J Phys Anthropol

authors

Vona G,Falchi A,Moral P,Calò CM,Varesi L

doi

10.1002/ajpa.20070

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

361-9

issue

3

eissn

0002-9483

issn

1096-8644

journal_volume

127

pub_type

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