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Non-linear mixed-effects pharmacokinetic/pharmacodynamic modelling in NLME using differential equations.

Abstract：

:The standard software for non-linear mixed-effect analysis of pharmacokinetic/pharmacodynamic (PK/PD) data is NONMEM while the non-linear mixed-effects package NLME is an alternative as long as the models are fairly simple. We present the nlmeODE package which combines the ordinary differential equation (ODE) solver package odesolve and the non-linear mixed effects package NLME thereby enabling the analysis of complicated systems of ODEs by non-linear mixed-effects modelling. The pharmacokinetics of the anti-asthmatic drug theophylline is used to illustrate the applicability of the nlmeODE package for population PK/PD analysis using the available data analysis tools in R for model inspection and validation. The nlmeODE package is numerically stable and provides accurate parameter estimates which are consistent with NONMEM estimates.

journal_name

Comput Methods Programs Biomed

journal_title

Computer methods and programs in biomedicine

authors

Tornøe CW,Agersø H,Jonsson EN,Madsen H,Nielsen HA

doi

10.1016/j.cmpb.2004.01.001

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

31-40

issue

1

eissn

0169-2607

issn

1872-7565

pii

S0169260704000136

journal_volume

76

pub_type

杂志文章

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